{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:20:40Z","timestamp":1791091240747,"version":"4.1.0"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFN\u03b3+874T\/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFN\u03b3+874T\/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.<\/jats:p>","DOI":"10.1590\/s0037-86822012000600020","type":"journal-article","created":{"date-parts":[[2013,1,5]],"date-time":"2013-01-05T07:48:27Z","timestamp":1357372107000},"page":"757-760","source":"Crossref","is-referenced-by-count":18,"title":["Genetic polymorphism for IFN\u03b3 +874T\/A in patients with acute toxoplasmosis"],"prefix":"10.1590","volume":"45","author":[{"given":"Elizabeth de Souza","family":"Neves","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Luis Land","family":"Curi","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira Cavalcanti de","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Instituto Oswaldo Cruz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassius Schnel","family":"Palhano-Silva","sequence":"additional","affiliation":[{"name":"Escola Nacional de Sa\u00fade P\u00fablica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Berriel da","family":"Silva","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy Fernandes","family":"Bueno","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Regina dos Reis","family":"Amendoeira","sequence":"additional","affiliation":[{"name":"Instituto Oswaldo Cruz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria da Gloria","family":"Bonecini-Almeida","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Instituto Oswaldo Cruz"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"Montoya JG","year":"2004","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1086\/511871","article-title":"Toxoplasma gondii pneumonia in immunocompetent subjects: case report and review","volume":"44","author":"Leal FE","year":"2007","journal-title":"Clin Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1258\/td.2010.100228","article-title":"Disseminated toxoplasmosis: an atypical presentation in an immunocompetent patient","volume":"41","author":"Neves ES","year":"2011","journal-title":"Trop Doct","ISSN":"https:\/\/id.crossref.org\/issn\/0049-4755","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0002-9394(14)73976-5","article-title":"An unusually high prevalence of ocular toxoplasmosis in southern Brazil","volume":"114","author":"Glasner PD","year":"1992","journal-title":"Am J Ophthalmol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9394","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1590\/S0074-02762009000200039","article-title":"Acute acquired toxoplasmosis: clinical-laboratorial aspects and ophthalmologic evaluation in a cohort of immunocompetent patients","volume":"104","author":"Neves ES","year":"2009","journal-title":"Mem Inst Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1126\/science.3128869","article-title":"Interferon-gamma: the major mediator of resistance against Toxoplasma gondii","volume":"240","author":"Suzuki Y","year":"1988","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"ref7","first-page":"1845","article-title":"Interleukin-1 gene polymorphisms and toxoplasmic retinochoroiditis","volume":"14","author":"Cordeiro CA","year":"2008","journal-title":"Mol Vis","ISSN":"https:\/\/id.crossref.org\/issn\/1090-0535","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1167\/iovs.07-1393","article-title":"Interleukin-10 gene polymorphism (-1082G\/A) is associated with toxoplasmic retinochoroiditis","volume":"49","author":"Cordeiro CA","year":"2008","journal-title":"Invest Ophthalmol Vis Sci","ISSN":"https:\/\/id.crossref.org\/issn\/0146-0404","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1590\/S0074-02762009000300009","article-title":"The IFN-gamma +874T\/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility","volume":"104","author":"Albuquerque MC","year":"2009","journal-title":"Mem Inst Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0198-8859(00)00167-1","article-title":"A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production","volume":"61","author":"Pravica V","year":"2000","journal-title":"Hum Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0198-8859","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00439-008-0497-5","article-title":"IFNG +874T\/A, IL10 -1082G\/A and TNF -308G\/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study","volume":"123","author":"Pacheco AG","year":"2008","journal-title":"Hum Genet","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6717","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/sj.gene.6364353","article-title":"IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan","volume":"8","author":"Salih MA","year":"2007","journal-title":"Genes Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/jmv.10472","article-title":"Polymorphisms in tumour necrosis factor-alpha, transforming growth factor-beta, interleukin-10, interleukin-6, interferon-gamma, and outcome of hepatitis C virus infection","volume":"71","author":"Barrett S","year":"2003","journal-title":"J Med Virol","ISSN":"https:\/\/id.crossref.org\/issn\/0146-6615","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tube.2005.03.001","article-title":"Cytokine gene polymorphisms in Colombian patients with different clinical presentations of tuberculosis","volume":"86","author":"Henao MI","year":"2006","journal-title":"Tuberculosis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/08830180213281","article-title":"The role of cytokines and their signaling pathways in the regulation of immunity to Toxoplasma gondii","volume":"21","author":"Lieberman LA","year":"2002","journal-title":"Int Rev Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0883-0185","issn-type":"print"}],"container-title":["Revista da Sociedade Brasileira de Medicina Tropical"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rsbmt\/v45n6\/20.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T07:15:45Z","timestamp":1495869345000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0037-86822012000600020&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0037-86822012000600020"],"URL":"https:\/\/doi.org\/10.1590\/s0037-86822012000600020","relation":{},"ISSN":["0037-8682"],"issn-type":[{"value":"0037-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}