{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T23:10:13Z","timestamp":1735686613283,"version":"3.32.0"},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Hosp. Clin."],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>A low frequency of Helicobacter pylori in the gastric mucosa of patients with alkaline gastritis has been reported. At the same time, it can be noted that the growth of bacteria can be inhibited by bile acids. We studied 40 patients with chronic gastritis related to Helicobacter pylori in order to determine the effect of ursodeoxycholic acid on this infection. Diagnoses of the infection and the inflammatory process were obtained by histologic study of gastric biopsies collected during endoscopy. Two groups were studied: group I received ursodeoxycholic acid - 300 mg\/day, and group II received the placebo, twice a day, both for 28 days. The colonization by Helicobacter pylori and the intensity of the mononuclear and polymorphonuclear inflammatory infiltrate were determined before (time 1) and after (time 2) treatment. Ursodeoxycholic acid had no effect on the Helicobacter pylori infection. A significant reduction in the intensity of the mononuclear inflammatory infiltrate of the gastric antrum mucosa was observed in patients from group I, when we compared not only times 1 and 2 but also groups I and II. However, this was not the case with the body mucosa. We concluded that ursodeoxycholic acid had no action on the colonization by Helicobacter pylori or on the polymorphonuclear inflammatory infiltrate, but it caused a significant reduction in the intensity of the mononuclear inflammatory infiltrate of the gastric antrum.<\/jats:p>","DOI":"10.1590\/s0041-87812000000600002","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T13:21:32Z","timestamp":1114608092000},"page":"201-206","source":"Crossref","is-referenced-by-count":2,"title":["Ursodeoxycholic acid does not interfere with in vivo Helicobacter pylori colonization"],"prefix":"10.1590","volume":"55","author":[{"given":"Jos\u00e9 Guilherme Nogueira da","family":"Silva","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Murilo Robilotta","family":"Zeitune","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aytan Miranda","family":"Sipahi","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Iryia","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio At\u00edlio","family":"Laudanna","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/BF01296612","article-title":"Effect of partial gastrectomy on serum anti-Helicobacter pylori immunoglobulins in peptic ulcer patients","volume":"36","author":"LAMERS CBHW","year":"1991","journal-title":"Dig Dis Sci","ISSN":"https:\/\/id.crossref.org\/issn\/0163-2116","issn-type":"print"},{"issue":"8517","key":"ref2","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0140-6736(86)92193-8","article-title":"Effect of duodenal ulcer surgery and enterogastric reflux on Campylobacter pyloridis","volume":"2","author":"O'CONNOR HJ","year":"1986","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/0016-5085(89)91504-7","article-title":"Effect of Roux-en-Y biliary diversion on Campylobacter pylori","volume":"97","author":"O'CONNOR HJ","year":"1989","journal-title":"Gastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1136\/jcp.40.11.1387-a","article-title":"Campylobacter pylori, acid, and bile","volume":"40","author":"TOMPKINS DS","year":"1987","journal-title":"J Clin Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9746","issn-type":"print"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1365-2036.1991.tb00533.x","article-title":"The effect of bile acids on the growth and adherence of Helicobacter pylori","volume":"5","author":"MATHAI E","year":"1991","journal-title":"Aliment Pharmacol Ther","ISSN":"https:\/\/id.crossref.org\/issn\/0269-2813","issn-type":"print"},{"issue":"3","key":"ref6","first-page":"233","article-title":"In Vivo susceptibility of Campylobacter pylori","volume":"84","author":"GRAHAM DY","year":"1989","journal-title":"Am J Gastroenterol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"issue":"suppl","key":"ref7","first-page":"100","article-title":"Helicobacter pylori: efeito do \u00e1cido ursodesoxic\u00f3lico sobre sua coloniza\u00e7\u00e3o na mucosa g\u00e1strica","volume":"50","author":"SILVA JGN","year":"1993","journal-title":"Rev Bras Med","ISSN":"https:\/\/id.crossref.org\/issn\/0034-7264","issn-type":"print"},{"year":"1990","author":"MISIEWICZ JJ","first-page":"1","key":"ref8"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.7326\/0003-4819-65-2-367","article-title":"Human Experimentation. 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