{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T16:56:42Z","timestamp":1761843402177,"version":"3.32.0"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Hosp. Clin."],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>PURPOSE: The differential diagnosis between benign and malignant adrenal cortical tumors circumscribed to the gland is controversial. One hundred and seven patients with adrenal cortex tumors (excluding those with primary hyperaldosteronism) were studied to assess the 5-year survival rate of adults, children, patients stratified by pathological stage, and patients stratified according to Weiss's score of &lt;3 or &gt;3. METHODS: The patients were evaluated both clinically and biochemically. One hundred and five patients underwent surgery and were classified pathologically as stages I, II, III, or IV. The tumors were weighed, measured, and classified according to Weiss's criteria and divided into 2 groups: &lt;3 and &gt;3. RESULTS: After 5 years, the survival rate was 77.5% for the whole group, 74.61% for the adults, 84.3% for the children, 100% for stage I, 83.9% for stage II, 33% for stage III, and 11.7% for stage IV groups. Additionally, after 5 years, 100% of the patients with tumors with Weiss's score &lt;3 were alive compared to 61.65% of those with Weiss's score &gt;3. The average weights of the tumors of score &lt;3 and &gt;3 were 23.38 g \u00b1 41.36 g and 376.3 \u00b1 538.76 g, respectively, which is a statistically significant difference. The average sizes of tumors of Weiss's score &lt;3 and &gt;3 were 3.67 \u00b1 2.2 cm and 9.64 \u00b1 5.8 cm, respectively, which is also a statistically significant difference. CONCLUSIONS: Weiss's score may be a good prognostic factor for tumors of the adrenal cortex. Additionally, there was a statistically significant difference between the average weight and size of tumors with benign behavior (Weiss's score &lt;3) and those with malignant behavior (Weiss's score &gt;3).<\/jats:p>","DOI":"10.1590\/s0041-87812002000600002","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T13:22:39Z","timestamp":1114608159000},"page":"251-256","source":"Crossref","is-referenced-by-count":24,"title":["Adrenocortical tumors: results of treatment and study of Weiss's score as a prognostic factor"],"prefix":"10.1590","volume":"57","author":[{"given":"Antonio Marmo","family":"Lucon","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Adelaide","family":"Pereira","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berenice B.","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Claudia","family":"Zerbini","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz B.","family":"Saldanha","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Arap","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00042307-199905000-00004","article-title":"Surgical options in adrenalectomy: laparoscopic versus open surgery","volume":"9","author":"JANETSCHEK G","year":"1999","journal-title":"Curr Opin Urol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1056\/NEJM199004263221705","article-title":"Clinical features of adrenocortical carcinoma, prognostic factors and the effect of mitotane therapy","volume":"322","author":"LUTON JP","year":"1990","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00000478-198403000-00001","article-title":"Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors","volume":"8","author":"WEISS LM","year":"1994","journal-title":"Am J Surg Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0147-5185","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/1097-0142(19850215)55:4<766::AID-CNCR2820550414>3.0.CO;2-7","article-title":"Morphologic characteristics of benign anal malignant adrenocortical tumors","volume":"55","author":"VAN SLOOTEN","year":"1985","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/ajcp\/72.3.390","article-title":"Prognostic factors in adrenal cortical tumors: a mathematical analysis of clinical and morphologic data","volume":"72","author":"HOUGH AJ","year":"1979","journal-title":"Am J Clin Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9173","issn-type":"print"},{"year":"1966","author":"MEDEIROS LJ","series-title":"The Difficult Diagnosis in Surgical Pathology","key":"ref6"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1365-2265.1997.d01-1751.x","article-title":"Incidentally discovered adrenal mass (incidentaloma): investigation and management of 208 patients","volume":"46","author":"KASPERLIK - ZATUSKA AA","year":"1997","journal-title":"Clin Endocrinol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"940","DOI":"10.7326\/0003-4819-98-6-940","article-title":"The incidentally discoveral adrenal mass","volume":"98","author":"COPELAND PM","year":"1983","journal-title":"Ann Intern Med","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4819","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/jama.1982.03330060041031","article-title":"Incidental asymptomatic adrenal masses detected by computed tomographic scanning: operation required?","volume":"248","author":"PRINZ RA","year":"1982","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"ref10","first-page":"155","article-title":"Cancer of the adrenal cortex the natural history, prognosis and treatment in a study of fifty -five cases","volume":"23","author":"MAC FARLANE DA","year":"1958","journal-title":"Ann R Coll Surg Engl","ISSN":"https:\/\/id.crossref.org\/issn\/0035-8843","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"KAPLAN EL","year":"1985","journal-title":"J Am Stat Assoc","ISSN":"https:\/\/id.crossref.org\/issn\/0162-1459","issn-type":"print"},{"key":"ref12","series-title":"Biostatistics: a foundation for analysis in the sciences","author":"DAMIEL WW","year":"1999","edition":"7"},{"key":"ref13","first-page":"55","article-title":"Incidentally discovered adrenal tumors: endocrine and scintigraphic correlates","volume":"83","author":"BARZON L","year":"1988","journal-title":"J Clin Endocrinol Met"},{"year":"1989","author":"VAUGHAN ED Jr","series-title":"Adrenal carcinoma: Adrenal disorders","key":"ref14"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s002689900407","article-title":"Adrenalectomy for primary aldosteronism long-term follow-up study in 29 patients","volume":"22","author":"SIREN J","year":"1988","journal-title":"World J Surg","ISSN":"https:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/S0022-5347(01)68151-5","article-title":"Cleveland Clinic Experience with Adrenal Cushing's Syndrome","volume":"158","author":"DAITCH JA","year":"1997","journal-title":"J Urol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-5347","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0022-5347(05)67888-3","article-title":"Diagnosis and management of adrenal incidentalomas","volume":"163","author":"BARZON L","year":"2000","journal-title":"J Urol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-5347","issn-type":"print"},{"year":"1997","author":"LACK EE","series-title":"Atlas of tumor pathology: tumors of the adrenal gland and extra-adrenal paraganglia","key":"ref18"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1210\/jcem.83.9.5068-1","article-title":"The role of laparoscopic surgery in adrenal disease","volume":"83","author":"WELLS AS","year":"1998","journal-title":"J Clin Endocrinol Melabol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/S0022-5347(01)66673-4","article-title":"Clinical hormonal and pathological findings in a comparative study of adrenocortical neoplasia in childhood and adulthood","volume":"154","author":"MENDON\u00c7A BB","year":"1995","journal-title":"J Urol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-5347","issn-type":"print"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/000313480006600115","article-title":"Clinical features and prognostic factors associated with adrenocortical carcinoma: Lahey Clinic Medical Center Experience","volume":"66","author":"TRITOS NA","year":"2000","journal-title":"Am Surg","ISSN":"https:\/\/id.crossref.org\/issn\/0003-1348","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0090-4295(75)90135-1","article-title":"Adrenocortical neoplasms","volume":"5","author":"TANG CK","year":"1975","journal-title":"Prognosis and Urology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/BF02067377","article-title":"Survival rates and prognostic factors in adrenocortical carcinoma","volume":"16","author":"ICARD","year":"1992","journal-title":"World J Surg","ISSN":"https:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"key":"ref24","first-page":"1076","article-title":"A small adrenocortical carcinoma with aggressive behavior: An evaluation of criteria for malignancy","volume":"110","author":"GANDOUR MJ","year":"1986","journal-title":"Arch Pathol Lab Med","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9985","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/1097-0142(19830815)52:4<707::AID-CNCR2820520424>3.0.CO;2-N","article-title":"Adrenal cortical carcinoma: Study of 77 cases","volume":"52","author":"NADER S","year":"1983","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1148\/radiology.202.2.9015083","article-title":"Quantitative CT evaluation of adrenal gland masses: a step formed in the differentiation between adenomas and nonadenomas?","volume":"202","author":"SZOLAR DH","year":"1997","journal-title":"Radiology","ISSN":"https:\/\/id.crossref.org\/issn\/0033-8419","issn-type":"print"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1001\/archsurg.134.2.181","article-title":"Pathologic features of prognostic significance for adrenocortical carcinoma after curative resection","volume":"134","author":"HARRISON LE","year":"1999","journal-title":"Arch Surg","ISSN":"https:\/\/id.crossref.org\/issn\/0004-0010","issn-type":"print"},{"key":"ref28","first-page":"1090","article-title":"Surgical management, DNA content, and patient survival in adrenal cortical carcinoma","volume":"18","author":"LEE JEL","year":"1995","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"}],"container-title":["Revista do Hospital das Cl\u00ednicas"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rhc\/v57n6\/a02v57n6.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T22:38:27Z","timestamp":1735684707000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0041-87812002000600002&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002]]}},"alternative-id":["S0041-87812002000600002"],"URL":"https:\/\/doi.org\/10.1590\/s0041-87812002000600002","relation":{},"ISSN":["0041-8781"],"issn-type":[{"type":"electronic","value":"0041-8781"}],"subject":[],"published":{"date-parts":[[2002]]}}}