{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:38:53Z","timestamp":1793785133913,"version":"4.6.1"},"reference-count":164,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1590\/s0074-02762011000900007","type":"journal-article","created":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T13:41:09Z","timestamp":1314625269000},"page":"52-63","source":"Crossref","is-referenced-by-count":160,"title":["Thrombocytopenia in malaria: who cares?"],"prefix":"10.1590","volume":"106","author":[{"given":"Marcus Vin\u00edcius Guimar\u00e3es","family":"Lacerda","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Brasil; Universidade do Estado do Amazonas, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paula Gomes","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Brasil; Universidade do Estado do Amazonas, Brasil; Universidade Nilton Lins, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Cristina Cardoso","family":"Coelho","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Barberino","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/tropej\/fmh107","article-title":"Plasmodium vivax malaria presenting with severe thrombocytopenia","volume":"51","author":"Aggarwal A","year":"2005","journal-title":"J Trop Pediatr","ISSN":"https:\/\/id.crossref.org\/issn\/0142-6338","issn-type":"print"},{"key":"ref2","series-title":"Clinical aspects, resistance and parasitary polymorphism of Plasmodium vivax malaria in Manaus","author":"Alecrim MGC","year":"2000"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3201\/eid1610.100685","article-title":"Severe Plasmodium vivax malaria, Brazilian Amazon","volume":"16","author":"Alexandre MA","year":"2010","journal-title":"Emerg Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1080-6040","issn-type":"print"},{"key":"ref4","series-title":"Trombocitopenia associada ao HCV: aspectos cl\u00ednico-laboratoriais e virol\u00f3gicos","author":"Almeida AJ","year":"2003"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1475-2875-9-13","article-title":"Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance","volume":"9","author":"Andrade BB","year":"2010","journal-title":"Malar J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1445-5994.1992.tb02801.x","article-title":"Profound thrombocytopenia due to Plasmodium vivax malaria","volume":"22","author":"Anstey NM","year":"1992","journal-title":"Aust N Z J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0004-8291","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1590\/S0074-02762008000600001","article-title":"The role of platelet and plasma markers of antioxidant status and oxidative stress in thrombocytopenia among patients with vivax malaria","volume":"103","author":"Araujo CF","year":"2008","journal-title":"Mem Inst Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref8","first-page":"25","article-title":"Plaquetopenia acentuada associada \u00e0 mal\u00e1ria pelo P. vivax. Anais do XIII Congresso Brasileiro de Infectologia, Goi\u00e2nia","volume":"7","author":"Ara\u00fajo Filho JA","year":"2003","journal-title":"Braz J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1413-8670","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"372","DOI":"10.5144\/0256-4947.2002.372","article-title":"Malaria: hematological aspects","volume":"22","author":"Bashawri LA","year":"2002","journal-title":"Ann Saudi Med","ISSN":"https:\/\/id.crossref.org\/issn\/0256-4947","issn-type":"print"},{"key":"ref10","series-title":"O paludismo na Amaz\u00f4nia: contribui\u00e7\u00e3o \u00e0 epidemiologia, \u00e0 protozoologia e \u00e0 cl\u00ednica; estudo s\u00f4bre a febre biliosa-hemoglobin\u00farica; s\u00edntese","author":"Batista D","year":"1946"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/bmj.1.5796.345","article-title":"Thrombocytopenia in malaria with immunoglobulin (IgM) changes","volume":"1","author":"Beale PJ","year":"1972","journal-title":"BMJ","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"key":"ref12","first-page":"749","article-title":"Mean platelet volume trend in sepsis: is it a useful parameter?","volume":"72","author":"Becchi C","year":"2006","journal-title":"Minerva Anestesiol","ISSN":"https:\/\/id.crossref.org\/issn\/0375-9393","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/09537100903518278","article-title":"Severe thrombocytopenia with bleeding manifestations in two children secondary to Plasmodium vivax","volume":"21","author":"Bhatia V","year":"2010","journal-title":"Platelets","ISSN":"https:\/\/id.crossref.org\/issn\/0953-7104","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1046\/j.1538-7836.2003.00332.x","article-title":"Substitutes and alternatives to platelet transfusions in thrombocytopenic patients","volume":"1","author":"Blajchman MA","year":"2003","journal-title":"J Thromb Haemost"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1128\/IAI.37.3.1227-1233.1982","article-title":"Plasmodium berghei malaria: blockage by immune complexes of macrophage receptors for opsonized plasmodia","volume":"37","author":"Brown KM","year":"1982","journal-title":"Infect Immun","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/1475-2875-9-327","article-title":"Augmented plasma microparticles during acute Plasmodium vivax infection","volume":"9","author":"Campos FM","year":"2010","journal-title":"Malar J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1086\/654815","article-title":"On the cytoadhesion of Plasmodium vivax-infected erythrocytes","volume":"202","author":"Carvalho BO","year":"2010","journal-title":"J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4269\/ajtmh.2006.75.434","article-title":"Thrombocytopenia in falciparum malaria is associated with high concentrations of IL-10","volume":"75","author":"Casals-Pascual C","year":"2006","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref19","series-title":"Hematological studies of impaludism","author":"Chagas C","year":"1903"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1086\/381900","article-title":"Platelet-induced autoagglutination of Plasmodium falciparum-infected red blood cells and disease severity in Thailand","volume":"189","author":"Chotivanich K","year":"2004","journal-title":"J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ijpara.2006.02.005","article-title":"Cerebral malaria: role of microparticles and platelets in alterations of the blood-brain barrier","volume":"36","author":"Combes V","year":"2006","journal-title":"Int J Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/0020-7519","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1423-0410.2003.00348.x","article-title":"Autoimmune thrombocytopenia in malaria","volume":"85","author":"Conte R","year":"2003","journal-title":"Vox Sang","ISSN":"https:\/\/id.crossref.org\/issn\/0042-9007","issn-type":"print"},{"key":"ref23","first-page":"112","article-title":"The in vitro and ex vivo effects of chloroquine sulphate on platelet function: implications for malaria prophylaxis in patients with impaired haemostasis","volume":"93","author":"Cummins D","year":"1990","journal-title":"J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0022-5304","issn-type":"print"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4269\/ajtmh.2002.66.481","article-title":"Clinical and laboratory predictors of imported malaria in an outpatient setting: an aid to medical decision making in returning travelers with fever","volume":"66","author":"D'Acremont V","year":"2002","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1590\/S0074-02762000000200011","article-title":"Is there a role for autoimmunity in immune protection against malaria?","volume":"95","author":"Daniel-Ribeiro CT","year":"2000","journal-title":"Mem Inst Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0001-706X(00)00099-1","article-title":"Autoimmunity and malaria: what are they doing together?","volume":"76","author":"Daniel-Ribeiro CT","year":"2000","journal-title":"Acta Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0001-706X","issn-type":"print"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0025-7125(16)31017-3","article-title":"Immunology of parasitic infections","volume":"69","author":"Davidson RA","year":"1985","journal-title":"Med Clin North Am","ISSN":"https:\/\/id.crossref.org\/issn\/0025-7125","issn-type":"print"},{"key":"ref28","first-page":"9","article-title":"Avalia\u00e7\u00e3o da efic\u00e1cia das transfus\u00f5es de concentrados de plaquetas nos Servi\u00e7os de Hematologia e Hemoterapia do Hospital de Cl\u00ednicas de Porto Alegre","volume":"15","author":"de Paula LV","year":"1993","journal-title":"Bol Soc Bras Hematol Hemoter"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.ijpara.2004.10.012","article-title":"Variant genes and the spleen in Plasmodium vivax malaria","volume":"34","author":"del Portillo HA","year":"2004","journal-title":"Int J Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/0020-7519","issn-type":"print"},{"key":"ref30","first-page":"713","article-title":"Depletion of coagulation factors in drug-resistant Plasmodium falciparum malaria","volume":"29","author":"Dennis LH","year":"1967","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1386-6346(02)00010-4","article-title":"Mechanisms for increment of platelet associated IgG and platelet surface IgG and their implications in immune thrombocytopenia associated with chronic viral liver disease","volume":"24","author":"Doi T","year":"2002","journal-title":"Hepatol Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S0036-46652003000100006","article-title":"Clinical and laboratory findings of Plasmodium vivax malaria in Colombia 2001","volume":"45","author":"Echeverri M","year":"2003","journal-title":"Rev Inst Med Trop Sao Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pt.2004.11.008","article-title":"The importance of the spleen in malaria","volume":"21","author":"Engwerda CR","year":"2005","journal-title":"Trends Parasitol"},{"key":"ref34","first-page":"207","article-title":"Role of lipids, lipoproteins and lipid peroxidation in thrombocytopenia in patients with vivax malaria","volume":"29","author":"Erel O","year":"1998","journal-title":"Haematologia (Budap)","ISSN":"https:\/\/id.crossref.org\/issn\/0017-6559","issn-type":"print"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0009-9120(01)00221-1","article-title":"Oxidative stress of platelets and thrombocytopenia in patients with vivax malaria","volume":"34","author":"Erel O","year":"2001","journal-title":"Clin Biochem","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9120","issn-type":"print"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1055\/s-0038-1653407","article-title":"Platelet hypersensitivity in acute malaria (Plasmodium falciparum) infection in man","volume":"46","author":"Essien EM","year":"1981","journal-title":"Thromb Haemost","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6245","issn-type":"print"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1001\/jama.1974.03230470047024","article-title":"Malarial parasites within human platelets","volume":"229","author":"Fajardo LF","year":"1974","journal-title":"J Am Med Assoc"},{"key":"ref38","first-page":"633","article-title":"Pathophysiology, diagnosis and treatment of disseminated intravascular coagulation: an update","volume":"51","author":"Franchini M","year":"2005","journal-title":"Clin Lab","ISSN":"https:\/\/id.crossref.org\/issn\/0366-6751","issn-type":"print"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S1995-7645(10)60135-6","article-title":"A study on the clinical profile of complicated Plasmodium vivax mono-infections","volume":"3","author":"George P","year":"2010","journal-title":"Asian Pac J Trop Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"686","DOI":"10.4269\/ajtmh.2002.66.686","article-title":"Prognostic value of thrombocytopenia in African children with falciparum malaria","volume":"66","author":"Gerardin P","year":"2002","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref41","first-page":"187","article-title":"Hematologic variations in patient with malaria caused by Plasmodium vivax before, during and after treatment","volume":"50","author":"Gonzalez B","year":"2009","journal-title":"Invest Clin","ISSN":"https:\/\/id.crossref.org\/issn\/0535-5133","issn-type":"print"},{"key":"ref42","first-page":"163","article-title":"Clinical and epidemiologic characteristics of 291 hospitalized patients for malaria in Medellin (Colombia)","volume":"25","author":"Gonzalez LM","year":"2000","journal-title":"Acta Med Colomb","ISSN":"https:\/\/id.crossref.org\/issn\/0120-2448","issn-type":"print"},{"key":"ref43","first-page":"501","article-title":"Immunopathology of thrombocytopenia in experimental malaria","volume":"65","author":"Grau GE","year":"1988","journal-title":"Immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0019-2805","issn-type":"print"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0140-6736(68)90595-3","article-title":"Autoimmune disease and parasitic infections in Nigerians","volume":"2","author":"Greenwood BM","year":"1968","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1111\/j.1469-0691.2007.01815.x","article-title":"Association between particular polymorphic residues on apical membrane antigen 1 (AMA-1) and platelet levels in patients with vivax malaria","volume":"13","author":"Grynberg P","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s12098-009-0087-0","article-title":"Plasmodium vivax malaria presenting with severe thrombocytopenia, cerebral complications and hydrocephalus","volume":"76","author":"Harish R","year":"2009","journal-title":"Indian J Pediatr","ISSN":"https:\/\/id.crossref.org\/issn\/0019-5456","issn-type":"print"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0140-6736(64)92347-5","article-title":"Thrombocytopenia in vivax malaria","volume":"39","author":"Hill GJ","year":"1964","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/infdis\/158.2.325","article-title":"High-dose dexamethasone in quinine-treated patients with cerebral malaria: a double-blind, placebo-controlled trial","volume":"158","author":"Hoffman SL","year":"1988","journal-title":"J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"key":"ref49","article-title":"Severe thrombocytopenia and epistaxis secondary to Plasmodium vivax infection","volume":"3","author":"Holland BH","year":"2004","journal-title":"Internet J Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"841","DOI":"10.4269\/ajtmh.2009.80.841","article-title":"Increased phagocytosis of platelets from patients with secondary dengue virus infection by human macrophages","volume":"80","author":"Honda S","year":"2009","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S1473-3099(05)70138-9","article-title":"Problem pathogens: extra-intestinal complications of Salmonella enterica serotype typhi infection","volume":"5","author":"Huang DB","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2141.1987.tb06926.x","article-title":"Platelet reactions after interaction with cultured Plasmodium falciparum infected erythrocytes","volume":"66","author":"Inyang AL","year":"1987","journal-title":"Br J Haematol","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1048","issn-type":"print"},{"key":"ref53","first-page":"615","article-title":"Thrombocytopenia in malaria - correlation with type and severity of malaria","volume":"52","author":"Jadhav UM","year":"2004","journal-title":"J Assoc Physicians India","ISSN":"https:\/\/id.crossref.org\/issn\/0004-5772","issn-type":"print"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1136\/jcp.38.11.1318","article-title":"Platelet phagocytosis: a probable mechanism of thrombocytopenia in Plasmodium falciparum infection","volume":"38","author":"Jaff MS","year":"1985","journal-title":"J Clin Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9746","issn-type":"print"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0732-8893(99)00069-3","article-title":"Profound thrombocytopenia in Plasmodium vivax malaria","volume":"35","author":"Kakar A","year":"1999","journal-title":"Diagn Microbiol Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/0732-8893","issn-type":"print"},{"key":"ref56","series-title":"Platelets","first-page":"559","volume-title":"HIV-1 related thrombocytopenia","author":"Karpatkin S","year":"2002"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1073\/pnas.92.6.2263","article-title":"Sequestration of anti-platelet GPIIIa antibody in rheumatoid factor immune complexes of human immunodeficiency virus 1 thrombocytopenic patients","volume":"92","author":"Karpatkin S","year":"1995","journal-title":"Proc Natl Acad Sci USA","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"ref58","first-page":"147","article-title":"Thrombocytopenia in Plasmodium vivax infected children","volume":"43","author":"Katira B","year":"2006","journal-title":"J Vector Borne Dis"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/tropej\/fml092","article-title":"Unusual presentation of Plasmodium vivax malaria with severe thrombocytopenia and acute renal failure","volume":"53","author":"Kaur D","year":"2007","journal-title":"J Trop Pediatr","ISSN":"https:\/\/id.crossref.org\/issn\/0142-6338","issn-type":"print"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1172\/JCI110836","article-title":"Immune-mediated thrombocytopenia of malaria","volume":"71","author":"Kelton JG","year":"1983","journal-title":"J Clin Invest","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tmaid.2009.01.003","article-title":"Imported malaria in Qatar: a one year hospital-based study in 2005","volume":"7","author":"Khan FY","year":"2009","journal-title":"Travel Med Infect Dis"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3109\/09537104.2010.505308","article-title":"Thrombocytopenia in Plasmodium falciparum, Plasmodium vivax and mixed infection malaria: a study from Bikaner (Northwestern India)","volume":"21","author":"Kochar DK","year":"2010","journal-title":"Platelets","ISSN":"https:\/\/id.crossref.org\/issn\/0953-7104","issn-type":"print"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3201\/eid1101.040519","article-title":"Plasmodium vivax malaria","volume":"11","author":"Kochar DK","year":"2005","journal-title":"Emerg Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1080-6040","issn-type":"print"},{"key":"ref64","first-page":"535","article-title":"Supportive presumptive diagnosis of Plasmodium vivax malaria: Thrombocytopenia and red cell distribution width","volume":"28","author":"Koltas IS","year":"2007","journal-title":"Saudi Med J","ISSN":"https:\/\/id.crossref.org\/issn\/0379-5284","issn-type":"print"},{"key":"ref65","first-page":"1453","article-title":"Plasmodium vivax malaria with clinical presentation mimicking acute type idiopathic thrombocytopenic purpura (abstract)","volume":"47","author":"Komoda M","year":"2006","journal-title":"Rinsho Ketsueki","ISSN":"https:\/\/id.crossref.org\/issn\/0485-1439","issn-type":"print"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/milmed\/163.2.84","article-title":"A review of 79 patients with malaria seen at a military hospital in Hawaii from 1979 to 1995","volume":"163","author":"Kortepeter M","year":"1998","journal-title":"Mil Med","ISSN":"https:\/\/id.crossref.org\/issn\/0026-4075","issn-type":"print"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1046\/j.1365-2141.2000.02096.x","article-title":"Thrombopoietin in Plasmodium falciparum malaria","volume":"109","author":"Kreil A","year":"2000","journal-title":"Br J Haematol","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1048","issn-type":"print"},{"key":"ref68","first-page":"505","article-title":"Thrombocytopenia: an indicator of acute vivax malaria","volume":"49","author":"Kumar A","year":"2006","journal-title":"Indian J Pathol Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0377-4929","issn-type":"print"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.actatropica.2003.12.001","article-title":"Idiopathic thrombocytopenic purpura due to vivax malaria in the Brazilian Amazon","volume":"90","author":"Lacerda MV","year":"2004","journal-title":"Acta Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0001-706X","issn-type":"print"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1590\/S0037-86822008000500021","article-title":"Chronic Plasmodium vivax infection in a patient with splenomegaly and severe thrombocytopenia","volume":"41","author":"Lacerda MV","year":"2008","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref71","series-title":"Manifesta\u00e7\u00f5es cl\u00ednicas e patog\u00eanese da plaquetopenia na mal\u00e1ria","author":"Lacerda MVG","year":"2007"},{"key":"ref72","first-page":"104","article-title":"Avalia\u00e7\u00e3o das indica\u00e7\u00f5es de transfus\u00e3o de concentrado de plaquetas: Anais do XLII Congresso da Sociedade Brasileira de Medicina Tropical, Teresina","volume":"39","author":"Lacerda MVG","year":"2006","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref73","first-page":"336","article-title":"Clinical study of patients with falciparum malaria admitted to the Tropical Medicine Foundation of Amazonas - Brazil: Annals of the 50th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Atlanta (USA)","volume":"65","author":"Lacerda MVG","year":"2001","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1590\/S0037-86822007000100023","article-title":"Splenic hematoma in a patient with Plasmodium vivax malaria","volume":"40","author":"Lacerda MVG","year":"2007","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1046\/j.1365-2141.2002.03904.x","article-title":"Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome","volume":"119","author":"Ladhani S","year":"2002","journal-title":"Br J Haematol","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1048","issn-type":"print"},{"key":"ref76","first-page":"239","article-title":"Can hematological parameters discriminate malaria from nonmalarious acute febrile illness in the tropics?","volume":"58","author":"Lathia TB","year":"2004","journal-title":"Indian J Med Sci","ISSN":"https:\/\/id.crossref.org\/issn\/0019-5359","issn-type":"print"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-0038-1655955","article-title":"Plasma macrophage colony-stimulating factor and P-selectin levels in malaria-associated thrombocytopenia","volume":"77","author":"Lee SH","year":"1997","journal-title":"Thromb Haemost","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6245","issn-type":"print"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1182\/blood-2005-01-0243","article-title":"Role of molecular mimicry to HIV-1 peptides in HIV-1-related immunologic thrombocytopenia","volume":"106","author":"Li Z","year":"2005","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1600-0684.2006.00151.x","article-title":"Surgical bone marrow aspiration in Aotus lemurinus griseimembra","volume":"35","author":"Llanos C","year":"2006","journal-title":"J Med Primatol","ISSN":"https:\/\/id.crossref.org\/issn\/0047-2565","issn-type":"print"},{"key":"ref80","first-page":"1397","article-title":"Platelets play an important role in TNF-induced microvascular endothelial cell pathology","volume":"151","author":"Lou J","year":"1997","journal-title":"Am J Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1475-2875-9-S3-S4","article-title":"Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya","volume":"9","author":"Maina RN","year":"2010","journal-title":"Malar J"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1590\/S1413-86702002000500008","article-title":"Plasmodium vivax malaria presenting with severe thrombocytopenia","volume":"6","author":"Makkar RP","year":"2002","journal-title":"Braz J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1413-8670","issn-type":"print"},{"key":"ref83","series-title":"Altera\u00e7\u00f5es da hemostasia em pacientes com mal\u00e1ria","author":"Marques HO","year":"2004"},{"key":"ref84","first-page":"1452","article-title":"Hemostatic changes in patients with malaria: Annals of the XX Congress of the International Society on Thrombosis and Hemostasis, Sydney (Australia)","volume":"3","author":"Marques HO","year":"2005","journal-title":"J Thromb Haemost"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1462-5822.2010.01523.x","article-title":"Strain-specific spleen remodelling in Plasmodium yoelii infections in Balb\/c mice facilitates adherence and spleen macrophage-clearance escape","volume":"13","author":"Martin-Jaular L","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1365-2141.2010.08399.x","article-title":"Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy","volume":"151","author":"Mast Q","year":"2010","journal-title":"Br J Haematol","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1048","issn-type":"print"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1086\/519844","article-title":"Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria","volume":"196","author":"Mast Q","year":"2007","journal-title":"J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0169-4758(00)01774-9","article-title":"Malaria-related anaemia","volume":"16","author":"Menendez C","year":"2000","journal-title":"Parasitol Today","ISSN":"https:\/\/id.crossref.org\/issn\/0169-4758","issn-type":"print"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1096-8652(199701)54:1<23::AID-AJH4>3.0.CO;2-6","article-title":"Fibrinolysis, inhibitors of blood coagulation, and monocyte derived coagulant activity in acute malaria","volume":"54","author":"Mohanty D","year":"1997","journal-title":"Am J Hematol","ISSN":"https:\/\/id.crossref.org\/issn\/0361-8609","issn-type":"print"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0035-9203(88)90122-8","article-title":"Functional and ultrastructural changes of platelets in malarial infection","volume":"82","author":"Mohanty D","year":"1988","journal-title":"Trans R Soc Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref91","first-page":"245","article-title":"Adjuvant therapy in cerebral malaria","volume":"124","author":"Mohanty S","year":"2006","journal-title":"Indian J Med Res","ISSN":"https:\/\/id.crossref.org\/issn\/0971-5916","issn-type":"print"},{"key":"ref92","first-page":"18","article-title":"Atypical manifestations of Plasmodium vivax malaria","volume":"39","author":"Mohapatra MK","year":"2002","journal-title":"Indian J Malariol","ISSN":"https:\/\/id.crossref.org\/issn\/0367-8326","issn-type":"print"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1473-3099(01)00016-0","article-title":"Yellow fever: an update","volume":"1","author":"Monath TP","year":"2001","journal-title":"Lancet Infect Dis"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1136\/adc.88.6.540","article-title":"Thrombocytopenia and Plasmodium falciparum malaria in children with different exposures","volume":"88","author":"Moulin F","year":"2003","journal-title":"Arch Dis Child","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9888","issn-type":"print"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/09537100701426604","article-title":"Thrombocytopenia in patients with dengue virus infection in the Brazilian Amazon","volume":"18","author":"Mour\u00e3o MP","year":"2007","journal-title":"Platelets","ISSN":"https:\/\/id.crossref.org\/issn\/0953-7104","issn-type":"print"},{"key":"ref96","first-page":"71","article-title":"Estudo cl\u00ednico em crian\u00e7as internadas com mal\u00e1ria (P. falciparum) na FMT-AM: Anais do XXXVII Congresso da Sociedade Brasileira de Medicina Tropical, Salvador","volume":"34","author":"Mour\u00e3o MPG","year":"2001","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/157488407779422285","article-title":"Immunomodulatory therapy associated to anti-parasite drugs as a way to prevent severe forms of malaria","volume":"2","author":"Muniz-Junqueira MI","year":"2007","journal-title":"Curr Clin Pharmacol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.actatropica.2005.03.002","article-title":"Thalidomide influences the function of macrophages and increases the survival of Plasmodium berghei-infected CBA mice","volume":"94","author":"Muniz-Junqueira MI","year":"2005","journal-title":"Acta Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0001-706X","issn-type":"print"},{"key":"ref99","first-page":"160","article-title":"Clinical profile of falciparum malaria in a tertiary care hospital","volume":"98","author":"Murthy GL","year":"2000","journal-title":"J Indian Med Assoc","ISSN":"https:\/\/id.crossref.org\/issn\/0019-5847","issn-type":"print"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"7589","DOI":"10.1073\/pnas.94.14.7589","article-title":"GPIIIa(49-66) is a major pathophysiologically relevant antigenic determinant for anti-platelet GPIIIa of HIV-1-related immunologic thrombocytopenia","volume":"94","author":"Nardi MA","year":"1997","journal-title":"Proc Natl Acad Sci USA","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"ref101","series-title":"Mal\u00e1ria - aspectos hematol\u00f3gicos","author":"Naveira JB","year":"1970"},{"key":"ref102","series-title":"An\u00e1lise de aspectos microsc\u00f3picos, imuno-histoqu\u00edmicos e ultra-estruturais do pulm\u00e3o na leptospirose para a compreens\u00e3o da patogenia da plaquetopenia","author":"Nicodemo AC","year":"1993"},{"key":"ref103","series-title":"Estudo cl\u00ednico-epidemiol\u00f3gico da mal\u00e1ria falciparum em crian\u00e7as de 0 a 14 anos, atendidas no Instituto de Medicina Tropical do Amazonas em Manaus - AM - Brasil","author":"Noronha EF","year":"1998"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4269\/ajtmh.2001.65.143","article-title":"Clinical features of vivax malaria","volume":"65","author":"Oh MD","year":"2001","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref105","first-page":"490","article-title":"A case of vivax malaria with thrombocytopenia suggesting immunological mechanisms","volume":"34","author":"Ohtaka M","year":"1993","journal-title":"Rinsho Ketsueki","ISSN":"https:\/\/id.crossref.org\/issn\/0485-1439","issn-type":"print"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1073\/pnas.98.4.1805","article-title":"Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria","volume":"98","author":"Pain A","year":"2001","journal-title":"Proc Natl Acad Sci USA","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"ref107","first-page":"85","article-title":"Autoimmune thrombocytopenia in recurrent polietiological malaria (Plasmodium falciparum, Plasmodium vivax)","volume":"47","author":"Panasiuk A","year":"2001","journal-title":"Wiad Parazytol","ISSN":"https:\/\/id.crossref.org\/issn\/0043-5163","issn-type":"print"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"e13415","DOI":"10.1371\/journal.pone.0013415","article-title":"Elevated cell-specific microparticles are a biological marker for cerebral dysfunctions in human severe malaria","volume":"5","author":"Pankoui Mfonkeu JB","year":"2010","journal-title":"PLoS ONE"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1179\/027249309X12547917868844","article-title":"Plasmodium vivax malaria in children: uncommon manifestations","volume":"29","author":"Parakh A","year":"2009","journal-title":"Ann Trop Paediatr","ISSN":"https:\/\/id.crossref.org\/issn\/0272-4936","issn-type":"print"},{"key":"ref110","first-page":"370","article-title":"Plaquetopenia em pacientes com mal\u00e1ria por Plasmodium vivax: Anais do XXXVIII Congresso da Sociedade Brasileira de Medicina Tropical, Foz do Igua\u00e7u","volume":"35","author":"Park CHL","year":"2002","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1179\/000349803235002416","article-title":"Serum cytokine profiles in patients with Plasmodium vivax malaria: a comparison between those who presented with and without thrombocytopenia","volume":"97","author":"Park JW","year":"2003","journal-title":"Ann Trop Med Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4983","issn-type":"print"},{"key":"ref112","first-page":"1212","article-title":"Thrombocytopenia in malaria","volume":"96","author":"Patel U","year":"2004","journal-title":"J Natl Med Assoc","ISSN":"https:\/\/id.crossref.org\/issn\/0027-9684","issn-type":"print"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00042737-200104000-00004","article-title":"Hypersplenism","volume":"13","author":"Peck-Radosavljevic M","year":"2001","journal-title":"Eur J Gastroenterol Hepatol","ISSN":"https:\/\/id.crossref.org\/issn\/0954-691X","issn-type":"print"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1128\/IAI.68.7.3822-3829.2000","article-title":"Delayed mortality and attenuated thrombocytopenia associated with severe malaria in urokinase- and urokinase receptor-deficient mice","volume":"68","author":"Piguet PF","year":"2000","journal-title":"Infect Immun","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1086\/599041","article-title":"Vivax malaria: a major cause of morbidity in early infancy","volume":"48","author":"Poespoprodjo JR","year":"2009","journal-title":"Clin Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/tropej\/fmp028","article-title":"Coagulation status and platelet functions in children with severe falciparum malaria and their correlation of outcome","volume":"55","author":"Prasad R","year":"2009","journal-title":"J Trop Pediatr","ISSN":"https:\/\/id.crossref.org\/issn\/0142-6338","issn-type":"print"},{"key":"ref117","first-page":"220","article-title":"Clinical and laboratory findings in acute malaria caused by various plasmodium species","volume":"59","author":"Rasheed A","year":"2009","journal-title":"J Pak Med Assoc"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1423-0410.2000.tb00058.x","article-title":"Trigger for platelet transfusion","volume":"78","author":"Rebulla P","year":"2000","journal-title":"Vox Sang","ISSN":"https:\/\/id.crossref.org\/issn\/0042-9007","issn-type":"print"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1046\/j.1468-0734.2001.00042.x","article-title":"Revisitation of the clinical indications for the transfusion of platelet concentrates","volume":"5","author":"Rebulla P","year":"2001","journal-title":"Rev Clin Exp Hematol"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1708-8305.2007.00178.x","article-title":"Atypical Plasmodium vivax malaria in a traveler: bilateral hydronephrosis, severe thrombocytopenia, and hypotension","volume":"15","author":"Rifakis PM","year":"2008","journal-title":"J Travel Med","ISSN":"https:\/\/id.crossref.org\/issn\/1195-1982","issn-type":"print"},{"key":"ref121","first-page":"561","article-title":"Temporal evolution of platelets and anti-platelet antibodies in patients of endemic area with non complicated malaria","volume":"22","author":"Rios-Orrego A","year":"2005","journal-title":"An Med Interna","ISSN":"https:\/\/id.crossref.org\/issn\/0212-7199","issn-type":"print"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2310\/7060.2001.24309","article-title":"Imported malaria treated in Melbourne, Australia: epidemiology and clinical features in 246 patients","volume":"8","author":"Robinson P","year":"2001","journal-title":"J Travel Med","ISSN":"https:\/\/id.crossref.org\/issn\/1195-1982","issn-type":"print"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/tropej\/fmi069","article-title":"Anemia and thrombocytopenia in children with Plasmodium vivax malaria","volume":"52","author":"Rodriguez-Morales AJ","year":"2006","journal-title":"J Trop Pediatr","ISSN":"https:\/\/id.crossref.org\/issn\/0142-6338","issn-type":"print"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1086\/430837","article-title":"Occurrence of thrombocytopenia in Plasmodium vivax malaria","volume":"41","author":"Rodriguez-Morales AJ","year":"2005","journal-title":"Clin Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/adc.2003.045179","article-title":"Thrombocytopenia is predictive of lethality in severe childhood falciparum malaria","volume":"89","author":"Rogier C","year":"2004","journal-title":"Arch Dis Child","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9888","issn-type":"print"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1046\/j.1365-2141.1999.01469.x","article-title":"Differentiation of autoimmune thrombocytopenia from thrombocytopenia associated with immune complex disease: systemic lupus erythematosus, hepatitis-cirrhosis, and HIV-1 infection by platelet and serum immunological measurements","volume":"105","author":"Samuel H","year":"1999","journal-title":"Br J Haematol","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1048","issn-type":"print"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3201\/eid1307.061386","article-title":"Chloroquine-resistant Plasmodium vivax, Brazilian Amazon","volume":"13","author":"Santana Filho FS","year":"2007","journal-title":"Emerg Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1080-6040","issn-type":"print"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3201\/eid1207.060074","article-title":"Human hantavirus infection, Brazilian Amazon","volume":"12","author":"Santos MC","year":"2006","journal-title":"Emerg Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1080-6040","issn-type":"print"},{"key":"ref129","series-title":"Correla\u00e7\u00e3o entre n\u00edveis s\u00e9ricos de Intermedi\u00e1rios Reativos de Nitrog\u00eanio (IRN) e mal\u00e1ria em pacientes da Funda\u00e7\u00e3o de Medicina Tropical do Amazonas (FMT\/IMT-AM)","author":"Santos PD","year":"2000"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1054\/blre.2001.0188","article-title":"HIV-related thrombocytopenia","volume":"16","author":"Scaradavou A","year":"2002","journal-title":"Blood Rev","ISSN":"https:\/\/id.crossref.org\/issn\/0268-960X","issn-type":"print"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1473-0502(03)00039-9","article-title":"Platelet dosing","volume":"28","author":"Schlossberg HR","year":"2003","journal-title":"Transfus Apher Sci"},{"key":"ref132","first-page":"708","article-title":"Thrombocytopenia in malaria","volume":"19","author":"Shaikh QH","year":"2009","journal-title":"J Coll Physicians Surg Pak"},{"key":"ref133","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1128\/IAI.44.1.130-136.1984","article-title":"Murine malaria: immune complexes inhibit Fc receptor-mediated phagocytosis","volume":"44","author":"Shear HL","year":"1984","journal-title":"Infect Immun","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"ref134","series-title":"Mal\u00e1ria vivax: manifesta\u00e7\u00f5es cl\u00ednicas e laboratoriais relacionadas com o fator de necrose tumoral alfa","author":"Silva IBA","year":"2004"},{"key":"ref135","series-title":"Avalia\u00e7\u00e3o da frequ\u00eancia e dos fatores associados \u00e0 plaquetopenia causada pelo Plasmodium vivax","author":"Silva SBR","year":"2009"},{"key":"ref136","first-page":"348","article-title":"Perfil cl\u00ednico e hematol\u00f3gico dos pacientes internados com mal\u00e1ria por Plasmodium vivax e plaquetopenia, na Funda\u00e7\u00e3o de Medicina Tropical do Amazonas, no per\u00edodo de janeiro de 1997 a setembro de 1999: Anais do XXXVI Congresso da Sociedade Brasileira de Medicina Tropical, S\u00e3o Lu\u00eds do Maranh\u00e3o","volume":"33","author":"Silva SL","year":"2000","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref137","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1136\/bmj.2.5865.515","article-title":"Mechanisms of thrombocytopenia in malignant tertian malaria","volume":"2","author":"Skudowitz RB","year":"1973","journal-title":"BMJ","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"key":"ref138","doi-asserted-by":"crossref","first-page":"609","DOI":"10.4269\/ajtmh.2007.77.609","article-title":"Two cases of Plasmodium vivax malaria with the clinical picture resembling toxic shock","volume":"77","author":"Song JY","year":"2007","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref139","first-page":"225","article-title":"Platelet dysfunction in malaria","volume":"19","author":"Srichaikul T","year":"1988","journal-title":"Southeast Asian J Trop Med Public Health","ISSN":"https:\/\/id.crossref.org\/issn\/0038-3619","issn-type":"print"},{"key":"ref140","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0140-6736(75)92436-8","article-title":"Complement changes and disseminated intravascular coagulation in Plasmodium falciparum malaria","volume":"1","author":"Srichaikul T","year":"1975","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.actatropica.2010.10.001","article-title":"Retrospective analysis of vivax malaria patients presenting to tertiary referral centre of Uttarakhand","volume":"117","author":"Srivastava S","year":"2011","journal-title":"Acta Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0001-706X","issn-type":"print"},{"key":"ref142","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1590\/S0036-46652007000300005","article-title":"Cross sectional study reveals a high percentage of asymptomatic Plasmodium vivax infection in the Amazon Rio Negro area, Brazil","volume":"49","author":"Suarez-Mutis MC","year":"2007","journal-title":"Rev Inst Med Trop Sao Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref143","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.1128\/IAI.71.11.6553-6561.2003","article-title":"Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malaria","volume":"71","author":"Sun G","year":"2003","journal-title":"Infect Immun","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"ref144","doi-asserted-by":"crossref","first-page":"488","DOI":"10.11150\/kansenshogakuzasshi1970.65.488","article-title":"A case of Plasmodium vivax malaria with findings of DIC","volume":"65","author":"Takaki K","year":"1991","journal-title":"Kansenshogaku Zasshi","ISSN":"https:\/\/id.crossref.org\/issn\/0387-5911","issn-type":"print"},{"key":"ref145","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1475-2875-7-209","article-title":"Thrombocytopaenia in pregnant women with malaria on the Thai-Burmese border","volume":"7","author":"Tan SO","year":"2008","journal-title":"Malar J"},{"key":"ref146","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/1475-2875-7-259","article-title":"Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malaria","volume":"7","author":"Taylor WR","year":"2008","journal-title":"Malar J"},{"key":"ref147","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.vetimm.2005.11.001","article-title":"Presence of anti-platelet IgM and IgG antibodies in dogs naturally infected by Leishmania infantum","volume":"110","author":"Terrazzano G","year":"2006","journal-title":"Vet Immunol Immunopathol","ISSN":"https:\/\/id.crossref.org\/issn\/0165-2427","issn-type":"print"},{"key":"ref148","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/MPH.0b013e3181b7eb12","article-title":"Childhood Plasmodium vivax malaria with severe thrombocytopenia and bleeding manifestations","volume":"31","author":"Thapa R","year":"2009","journal-title":"J Pediatr Hematol Oncol","ISSN":"https:\/\/id.crossref.org\/issn\/1077-4114","issn-type":"print"},{"key":"ref149","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1371\/journal.pmed.0050128","article-title":"Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia","volume":"5","author":"Tjitra E","year":"2008","journal-title":"PLoS Med"},{"key":"ref150","first-page":"678","article-title":"Platelet antibody activity in malaria thrombocytopenia","volume":"38","author":"Touze JE","year":"1990","journal-title":"Pathol Biol (Paris)","ISSN":"https:\/\/id.crossref.org\/issn\/0369-8114","issn-type":"print"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1128\/IAI.73.1.201-207.2005","article-title":"The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents","volume":"73","author":"Tribulatti MV","year":"2005","journal-title":"Infect Immun","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"ref152","first-page":"12","article-title":"Naturally occurring plasmodia-specific circulating immune complexes in individuals of malaria endemic areas in India","volume":"36","author":"Tyagi P","year":"1999","journal-title":"Indian J Malariol","ISSN":"https:\/\/id.crossref.org\/issn\/0367-8326","issn-type":"print"},{"key":"ref153","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1128\/IAI.73.4.1986-1994.2005","article-title":"Fatal Plasmodium falciparum malaria causes specific patterns of splenic architectural disorganization","volume":"73","author":"Urban BC","year":"2005","journal-title":"Infect Immun","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"ref154","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1182\/blood-2004-06-2206","article-title":"Platelet depletion by anti-CD41 (alphaIIb) mAb injection early but not late in the course of disease protects against Plasmodium berghei pathogenesis by altering the levels of pathogenic cytokines","volume":"105","author":"van der Heyde HC","year":"2005","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"ref155","first-page":"55","article-title":"P\u00farpura trombocitop\u00eanica em paciente com mal\u00e1ria por Plasmodium vivax: relato de caso. Anais do XXXIV Congresso da Sociedade Brasileira de Medicina Tropical, Manaus","volume":"31","author":"Victoria MB","year":"1998","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref156","first-page":"123","article-title":"Malaria with marked thrombocytopenia: report of 2 cases","volume":"106","author":"Vij AS","year":"2008","journal-title":"J Indian Med Assoc","ISSN":"https:\/\/id.crossref.org\/issn\/0019-5847","issn-type":"print"},{"key":"ref157","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1056\/NEJM198202113060601","article-title":"Dexamethasone proves deleterious in cerebral malaria: A double-blind trial in 100 comatose patients","volume":"306","author":"Warrell DA","year":"1982","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref158","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1128\/IAI.74.1.645-653.2006","article-title":"Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum","volume":"74","author":"Wassmer SC","year":"2006","journal-title":"Infect Immun","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"ref159","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1086\/380761","article-title":"Platelets reorient Plasmodium falciparum-infected erythrocyte cytoadhesion to activated endothelial cells","volume":"189","author":"Wassmer SC","year":"2004","journal-title":"J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"key":"ref160","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.4049\/jimmunol.176.2.1180","article-title":"TGF-beta1 released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: a new mechanism for microvascular lesion during cerebral malaria","volume":"176","author":"Wassmer SC","year":"2006","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1128\/IAI.60.1.136-142.1992","article-title":"T-cell-dependent immunity and thrombocytopenia in rats infected with Plasmodium chabaudi","volume":"60","author":"Watier H","year":"1992","journal-title":"Infect Immun","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"ref162","series-title":"Guidelines for the treatment of malaria","year":"2010"},{"key":"ref163","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1053\/beha.1999.0072","article-title":"Blood and bone marrow changes in malaria","volume":"13","author":"Wickramasinghe SN","year":"2000","journal-title":"Baillieres Best Pract Res Clin Haematol"},{"key":"ref164","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/(SICI)1096-8652(199711)56:3<183::AID-AJH9>3.0.CO;2-U","article-title":"Severe thrombocytopenia suggesting immunological mechanisms in two cases of vivax malaria","volume":"56","author":"Yamaguchi S","year":"1997","journal-title":"Am J Hematol","ISSN":"https:\/\/id.crossref.org\/issn\/0361-8609","issn-type":"print"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/mioc\/v106s1\/07.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T07:24:48Z","timestamp":1741505088000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762011000900007&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":164,"journal-issue":{"issue":"suppl 1","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0074-02762011000900007"],"URL":"https:\/\/doi.org\/10.1590\/s0074-02762011000900007","relation":{},"ISSN":["0074-0276"],"issn-type":[{"value":"0074-0276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}