{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:59:55Z","timestamp":1789675195406,"version":"4.0.1"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>OBJETIVO: Estudar a rela\u00e7\u00e3o entre defici\u00eancia de vitamina D e cicatriza\u00e7\u00e3o de pele em pacientes com \u00falceras de perna, relacionar esta defici\u00eancia com caracter\u00edsticas da \u00falcera e avaliar se a reposi\u00e7\u00e3o de vitamina D nos indiv\u00edduos deficientes acelera a cicatriza\u00e7\u00e3o da \u00falcera. M\u00c9TODOS: Foram escolhidos aleatoriamente 26 pacientes com \u00falceras venosas de perna e 26 sem \u00falcera pareados para sexo, idade, HAS e tabagismo. Os grupos foram comparados com rela\u00e7\u00e3o \u00e0 dosagem s\u00e9rica de vitamina D. O grupo \u00falcera foi dividido em dois subgrupos: um que tomou placebo e outro que recebeu vitamina D 50.000UI por semana durante dois meses. Foi realizada a dosagem da 25-OH-vitamina D e avaliados o tamanho da \u00falcera e a gravidade da dor, antes e ap\u00f3s o tratamento. RESULTADOS: A maioria dos pacientes apresentava n\u00edveis insuficientes de vitamina D. N\u00e3o foi encontrada correla\u00e7\u00e3o entre o tamanho da \u00falcera sem tratamento e os n\u00edveis de vitamina D. Nos pacientes que receberam vitamina D, ap\u00f3s o tratamento, o tamanho mediano da \u00e1rea da \u00falcera, diminui de 25cm\u00b2, para 18cm\u00b2 e no grupo placebo, de 27cm\u00b2 para 24,5cm\u00b2 (p=0,7051 e p=0,7877, respectivamente). Considerando-se a variabilidade da \u00e1rea da \u00falcera do grupo vitamina D versus placebo, a mediana foi igual a -0,75cm\u00b2 no primeiro grupo e 4cm\u00b2 no segundo grupo (p=0,0676). CONCLUS\u00c3O: Pacientes com \u00falcera de perna t\u00eam mais defici\u00eancia de vitamina D que os sem. A defici\u00eancia de vitamina D n\u00e3o influiu nas caracter\u00edsticas das les\u00f5es. A cicatriza\u00e7\u00e3o nos pacientes com hipovitaminose D mostrou tend\u00eancia para ser maior naqueles que receberam reposi\u00e7\u00e3o vitam\u00ednica.<\/jats:p>","DOI":"10.1590\/s0100-69912012000500011","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T05:58:25Z","timestamp":1353477505000},"page":"401-407","source":"Crossref","is-referenced-by-count":49,"title":["Vitamina D e cicatriza\u00e7\u00e3o de pele: estudo prospectivo, duplo-cego, placebo controlado na cicatriza\u00e7\u00e3o de \u00falceras de perna"],"prefix":"10.1590","volume":"39","author":[{"given":"Claudine Juliana Cristina Caznoch","family":"Burkiewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Ampesaan","family":"Guadagnin","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Evang\u00e9lico de Curitiba, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thelma Laroka","family":"Skare","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Evang\u00e9lico de Curitiba, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Mazza do","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Evang\u00e9lico de Curitiba, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago Cirilo Nogueira","family":"Servin","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Evang\u00e9lico de Curitiba, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleim Dias de","family":"Souza","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Evang\u00e9lico de Curitiba, 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