{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T03:40:04Z","timestamp":1714880404450},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>OBJETIVO: Analisar a efic\u00e1cia da suspens\u00e3o de carv\u00e3o inerte na marca\u00e7\u00e3o de les\u00f5es impalp\u00e1veis mam\u00e1rias e as altera\u00e7\u00f5es morfol\u00f3gicas associadas ao seu uso, al\u00e9m de determinar se h\u00e1 ou n\u00e3o preju\u00edzo na interpreta\u00e7\u00e3o destas les\u00f5es pelo patologista. M\u00c9TODOS: Foram atendidos 135 casos de les\u00f5es impalp\u00e1veis mam\u00e1rias, previamente marcadas com suspens\u00e3o de carv\u00e3o. As l\u00e2minas coradas pelo m\u00e9todo de HE contendo pigmentos de carv\u00e3o foram analisadas ao microsc\u00f3pio \u00f3ptico, onde se realizou avalia\u00e7\u00e3o quantitativa e qualitativa da resposta inflamat\u00f3ria e determina\u00e7\u00e3o da presen\u00e7a ou n\u00e3o de preju\u00edzo ao diagn\u00f3stico anatomopatol\u00f3gico. Os \u00edndices avaliados quantitativamente quanto \u00e0 resposta inflamat\u00f3ria foram as contagens de linf\u00f3citos, c\u00e9lulas gigantes e neutr\u00f3filos, todos observados e quantificados em campos de grande aumento. Foi, ainda, avaliada a quantidade e distribui\u00e7\u00e3o de carv\u00e3o presente nas les\u00f5es. RESULTADOS: Na avalia\u00e7\u00e3o quantitativa e qualitativa da resposta inflamat\u00f3ria observou-se, independente da quantidade de carv\u00e3o, granulomas a \"corpo estranho\" em todas as amostras. Em rela\u00e7\u00e3o \u00e0 resposta inflamat\u00f3ria linfocit\u00e1ria 5,19% das amostras n\u00e3o apresentaram infiltra\u00e7\u00e3o linfoc\u00edtica, sendo que em 82,22% ela era de discreta intensidade e em 12,59% de moderada intensidade. Quanto \u00e0 resposta inflamat\u00f3ria aguda, observou-se aus\u00eancia total de exsuda\u00e7\u00e3o neutrof\u00edlica em 42,96% dos esp\u00e9cimes, exsuda\u00e7\u00e3o neutrof\u00edlica discreta em 42,22%, moderada em 11,11% e acentuada, sob forma de microabscessos, em 3,7% dos casos. Nesta s\u00e9rie foram observados cinco n\u00f3dulos de carv\u00e3o, posicionados paralesionalmente, e que n\u00e3o geraram interfer\u00eancia na an\u00e1lise morfol\u00f3gica. CONCLUS\u00c3O: Este m\u00e9todo \u00e9 marcador eficaz de les\u00f5es impalp\u00e1veis, de baixo custo, alta efetividade, sem preju\u00edzo \u00e0 an\u00e1lise histol\u00f3gica, al\u00e9m de ser de f\u00e1cil execu\u00e7\u00e3o; \u00e9 confort\u00e1vel para a paciente e de grande aux\u00edlio ao cirurgi\u00e3o e patologista na localiza\u00e7\u00e3o destas les\u00f5es.<\/jats:p>","DOI":"10.1590\/s0100-69912012000600005","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T09:41:08Z","timestamp":1358934068000},"page":"469-475","source":"Crossref","is-referenced-by-count":6,"title":["Les\u00f5es impalp\u00e1veis da mama marcadas com suspens\u00e3o de carv\u00e3o: avalia\u00e7\u00e3o de aspectos anatomopatol\u00f3gicos, viabilidade de interpreta\u00e7\u00e3o e resposta inflamat\u00f3ria"],"prefix":"10.1590","volume":"39","author":[{"given":"Teresa Cristina Santos","family":"Cavalcanti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo","family":"Malafaia","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica do Paran\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Afonso Nunes","family":"Nassif","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica do Paran\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thelma Larocca","family":"Skare","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica do Paran\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Cury","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Tizzot","family":"Miguel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Kr\u00fcger","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0748-7983(05)80067-8","article-title":"Pre-operative localization of non-palpable lesions in breast cancer by charcoal suspension","volume":"21","author":"Canavese G","year":"1995","journal-title":"Eur J Surg Oncol."},{"issue":"9","key":"ref2","first-page":"2007","article-title":"Mammographically guided fine-needle aspiration biopsy of nonpalpable breast lesions","volume":"68","author":"Layfield LJ","year":"1991","journal-title":"Can it replace open biopsy? 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