{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:14:18Z","timestamp":1791101658266,"version":"4.1.0"},"reference-count":175,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p>Occupational exposure to some pesticides, and particularly DBCP and chlordecone, may adversely affect male fertility. However, apart from the therapeutic use of diethylstilbestrol, the threat to human reproduction posed by \"endocrine disrupting\" environmental contaminants has not been supported by epidemiological evidence thus far. As it concerns other endocrine effects described in experimental animals, only thyroid inhibition following occupational exposure to amitrole and mancozeb has been confirmed in humans. Cancer of the breast, endometrium, ovary, prostate, testis, and thyroid are hormone-dependent, which fostered research on the potential risk associated with occupational and environmental exposure to the so-called endocrine-disrupting pesticides. The most recent studies have ruled out the hypothesis of DDT derivatives as responsible for excess risks of cancer of the reproductive organs. Still, we cannot exclude a role for high level exposure to o,p'-DDE, particularly in post-menopausal ER+ breast cancer. On the other hand, other organochlorine pesticides and triazine herbicides require further investigation for a possible etiologic role in some hormone-dependent cancers.<\/jats:p>","DOI":"10.1590\/s0102-311x2002000200003","type":"journal-article","created":{"date-parts":[[2005,4,20]],"date-time":"2005-04-20T17:36:35Z","timestamp":1114018595000},"page":"379-402","source":"Crossref","is-referenced-by-count":101,"title":["On the rumors about the silent spring: review of the scientific evidence linking occupational and environmental pesticide exposure to endocrine disruption health effects"],"prefix":"10.1590","volume":"18","author":[{"given":"Pierluigi","family":"Cocco","sequence":"first","affiliation":[{"name":"Universit\u00e0 degli Studi di Cagliari, Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.5271\/sjweh.573","article-title":"Semen quality and sexual hormones in greenhouse workers","volume":"26","author":"ABELL A.","year":"2000","journal-title":"Scandinavian Journal of Work, Environment & Health"},{"key":"ref2","first-page":"55","article-title":"Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk","volume":"9","author":"ARONSON K. 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M.","year":"1991","journal-title":"Brain Research Bulletin","ISSN":"https:\/\/id.crossref.org\/issn\/0361-9230","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1289\/ehp.99107501","article-title":"Cytogenetic effects from exposure to mixed pesticides and the influence from genetic susceptibility","volume":"107","author":"AU W. 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A.","year":"1997","journal-title":"Epidemiology","ISSN":"https:\/\/id.crossref.org\/issn\/1044-3983","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.5271\/sjweh.2208","article-title":"Cancer among farmers: A review","volume":"11","author":"BLAIR A.","year":"1985","journal-title":"Scandinavian Journal of Work, Environment & Health"},{"key":"ref15","series-title":"Occupational Medicine","volume-title":"Reproductive toxicology and occupational exposure","author":"BOGERT C. J.","year":"1994","edition":"3"},{"key":"ref16","first-page":"12","article-title":"Environmental semen studies - Is infertility increased by a decline in sperm count?","volume":"25","author":"BONDE J. P. 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F.","year":"1999","journal-title":"Cancer Causes & Control"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/0041-008X(89)90298-6","article-title":"Effects of chlordecone on progesterone receptors in immature and adult rats","volume":"100","author":"ECKOLS K.","year":"1989","journal-title":"Toxicology and Applied Pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0041-008X","issn-type":"print"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0140-6736(96)91190-3","article-title":"DDT and testicular cancer","volume":"347","author":"EKBOM A.","year":"1996","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref46","series-title":"Chemical Fact Sheets","year":"2000"},{"key":"ref47","series-title":"Federal Register Environmental Document - Pesticides","year":"2000"},{"key":"ref48","series-title":"Pesticide Information Profiles (PIPs)","year":"1996"},{"key":"ref49","first-page":"143","article-title":"Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer","volume":"47","author":"FALCK Jr. F.","year":"1992","journal-title":"Archives of Environmental Health","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9896","issn-type":"print"},{"key":"ref50","series-title":"Endocrinally Active Substances in the Environment: State of the Art","author":"FENT K.","year":"1997"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/oem.56.1.14","article-title":"Mortality in a cohort of licensed pesticide applicators in Florida","volume":"56","author":"FLEMING L. E.","year":"1999","journal-title":"Journal of Occupational and Environmental Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1076-2752","issn-type":"print"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00043764-199904000-00010","article-title":"Cancer incidence in a cohort of licensed pesticide applicators in Florida","volume":"41","author":"FLEMING L. E.","year":"1999","journal-title":"Journal of Occupational and Environmental Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1076-2752","issn-type":"print"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0002-9440(10)64736-0","article-title":"Overexpression of aromatase leads to development of testicular Leydig cell tumors: An in vivo model for hormone-mediated Testicular Cancer","volume":"156","author":"FOWLER K. A.","year":"2000","journal-title":"American Journal of Pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"ref54","first-page":"1090","article-title":"Exposure to pesticides and cryptorchidism: Geographical evidence of a possible association","volume":"104","author":"GARCIA-RODRIGUEZ J.","year":"1996","journal-title":"Environmental Health Perspectives","ISSN":"https:\/\/id.crossref.org\/issn\/0091-6765","issn-type":"print"},{"key":"ref55","first-page":"92","article-title":"Impact of nonlethal levels of Metacid-50 and carbaryl on thyroid function and cholinergic system of Channa punctatus","volume":"2","author":"GHOSH P.","year":"1989","journal-title":"Biomedical and Environmental Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0895-3988","issn-type":"print"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s002449900361","article-title":"Chlororganic pesticides and polychlorinated biphenyls in breast tissue of women with benign and malignant breast disease","volume":"35","author":"GUTTES S.","year":"1998","journal-title":"Archives of Environmental Contamination and Toxicology","ISSN":"https:\/\/id.crossref.org\/issn\/0090-4341","issn-type":"print"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/jnci\/82.12.1042","article-title":"Excess of seminomas observed in Vietnam service U. S. military working dogs","volume":"82","author":"HAYES H. M.","year":"1990","journal-title":"Journal of the National Cancer Institute","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8874","issn-type":"print"},{"key":"ref58","first-page":"375","article-title":"Pesticide\/Fertilizer mix III (Iowa)","volume":"105","author":"HEINDEL J. J.","year":"1997","journal-title":"Environmental Health Perspectives","ISSN":"https:\/\/id.crossref.org\/issn\/0091-6765","issn-type":"print"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/BF01299716","article-title":"Arbeitsbezogene Risikofaktoren des Prostatakarzinoms: Ergebnisse einer Fall-Kontroll-Studie","volume":"43","author":"HEISKEL H.","year":"1998","journal-title":"Sozial - und Praventivmedizin"},{"key":"ref60","series-title":"Cancer: Principles and Practice of Oncology","first-page":"219","volume-title":"Etiology of cancer: Hormonal factors","author":"HENDERSON B. E.","year":"1997","edition":"5t"},{"key":"ref61","first-page":"525","article-title":"Serum concentrations of organochlorine compounds and the subsequent development of breast cancer","volume":"8","author":"HELZLSOUER K. J.","year":"1998","journal-title":"Cancer Epidemiology, Biomarkes & Prevention"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1016\/S0140-6736(98)04504-8","article-title":"Organochlorine exposure and risk of breast cancer","volume":"352","author":"HOYER A. P.","year":"1998","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0895-4356(99)00165-1","article-title":"Organochlorine exposure and breast cancer survival","volume":"53","author":"HOYER A. P.","year":"2000","journal-title":"Journal of Clinical Epidemiology","ISSN":"https:\/\/id.crossref.org\/issn\/0895-4356","issn-type":"print"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1008926219539","article-title":"Repeated measurements of organochlorine exposure and breast cancer risk (Denmark)","volume":"11","author":"HOYER A. P.","year":"2000","journal-title":"Cancer Causes & Control"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJM199710303371801","article-title":"Plasma organochlorine levels and the risk of breast cancer","volume":"337","author":"HUNTER D. J.","year":"1997","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1289\/ehp.98106437","article-title":"Mode of carcinogenic action of pesticides inducing follicular cell tumors in rodents","volume":"106","author":"HURLEY P. M.","year":"1998","journal-title":"Environmental Health Perspectives","ISSN":"https:\/\/id.crossref.org\/issn\/0091-6765","issn-type":"print"},{"key":"ref67","series-title":"Occupational Exposures in Insecticide Application, and some Pesticides","first-page":"179","volume-title":"DDT and associated compounds","volume":"53","year":"1991"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/bmj.309.6952.476","article-title":"Falling sperm quality","volume":"309","author":"IRVINE D. 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J.","year":"2000","journal-title":"Toxicological Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/1096-6080","issn-type":"print"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s002449900276","article-title":"Blood levels of DDT and breast cancer risk among women living in the north of Vietnam","volume":"33","author":"SCHECTER A.","year":"1997","journal-title":"Archives of Environmental Contamination and Toxicology","ISSN":"https:\/\/id.crossref.org\/issn\/0090-4341","issn-type":"print"},{"key":"ref127","series-title":"Estrogenic Chemicals in the Environment: A New Problem?","author":"SEIBERT H.","year":"1997"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/375538a0","article-title":"Another DDT connection","volume":"375","author":"SHARPE R. 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M.","year":"1994","journal-title":"Environmental Health Perspectives","ISSN":"https:\/\/id.crossref.org\/issn\/0091-6765","issn-type":"print"},{"key":"ref136","first-page":"113","article-title":"The E-screen assay as a tool to identify estrogens: An update on estrogenic environmental pollutants","volume":"103","author":"SOTO A. 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