{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:36:39Z","timestamp":1785162999803,"version":"3.55.0"},"reference-count":44,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>This study analyzes 3,181 deaths from paracoccidioidomycosis in Brazil, based on 16 years of sequential data (from 1980 to 1995). During this period paracoccidioidomycosis showed considerable magnitude and low visibility, representing the eighth most common cause of death from predominantly chronic or recurrent types of infectious and parasitic diseases. It also had the highest mortality rate among the systemic mycoses. The mean annual mortality rate was 1.45 per million inhabitants, indicating a downward long-term trend (reduction of 31.28%), while spatial distribution among the different regions and States of Brazil was non-homogenous. The South (with the highest regional rate) and the Southeast showed a downward trend, while the Central West had the second highest rate in the country. At least one-fifth of Brazilian municipalities (or 22.71% of the country's total area) reported deaths from paracoccidioidomycosis. Overall nationwide mortality per area was 3.73\/10,000km\u00b2. The disease was endemic in non-metropolitan areas. The majority of deaths occurred in males (84.75%), and there was a sex ratio of 562 men\/100 women. The 30-59-year and over-60-year age groups were the most affected. The study showed that the mortality rate justifies classifying this disease as a major health problem in Brazil.<\/jats:p>","DOI":"10.1590\/s0102-311x2002000500037","type":"journal-article","created":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T20:30:19Z","timestamp":1178310619000},"page":"1441-1454","source":"Crossref","is-referenced-by-count":199,"title":["Paracoccidioidomycosis mortality in Brazil (1980-1995)"],"prefix":"10.1590","volume":"18","author":[{"given":"Ziadir Francisco","family":"Coutinho","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delson da","family":"Silva","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia","family":"Laz\u00e9ra","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria","family":"Petri","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosely Magalh\u00e3es de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo C.","family":"Sabroza","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodo","family":"Wanke","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","first-page":"165","article-title":"Paracoccidioidomicose linf\u00e1tico-abdominal: Contribui\u00e7\u00e3o ao seu estudo","volume":"12","author":"ANDRADE A. 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E.","year":"1988","journal-title":"Infection and Immunity","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"ref35","first-page":"88","article-title":"Paracoccidioidomycosis in women","volume":"15","author":"SEVERO L. C.","year":"1998","journal-title":"Revista Iberoamericana de Micolog\u00eda"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/02681219880000061","article-title":"Isolation of a Paracoccidioides brasiliensis strain from the soil of a coffee plantation in Ibi\u00e1, State of Minas Gerais, Brazil","volume":"36","author":"SILVA-VERGARA M. L.","year":"1998","journal-title":"Medical Mycology","ISSN":"https:\/\/id.crossref.org\/issn\/1369-3786","issn-type":"print"},{"key":"ref37","series-title":"Contribui\u00e7\u00e3o ao Estudo Cl\u00ednico da Paracoccidioidomicose na Crian\u00e7a","author":"TERRA G. M. F.","year":"1993"},{"key":"ref38","first-page":"65","article-title":"Tratamento da paracoccidioidomicose: Estudo retrospectivo de 500 casos: II - Avalia\u00e7\u00e3o dos resultados terap\u00eauticos com sulfanilam\u00eddicos, anfotericina B, associa\u00e7\u00e3o sulfametoxazol\/trimetoprim, cetoconazol e miconazol","volume":"68","author":"VALLE A. C. F.","year":"1993","journal-title":"Anais Brasileira de Dermatologia"},{"key":"ref39","first-page":"251","article-title":"Tratamento da paracoccidioidomicose: Estudo retrospectivo de 500 casos. I - An\u00e1lise cl\u00ednica, laboratorial e epidemiol\u00f3gica","volume":"67","author":"VALLE A. C. F.","year":"1992","journal-title":"Anais Brasileiros de Dermatologia","ISSN":"https:\/\/id.crossref.org\/issn\/0365-0596","issn-type":"print"},{"key":"ref40","series-title":"Paracoccidioidomicose: Estudo Epidemiol\u00f3gico e Cl\u00ednico de Pacientes Internados no Hospital de Doen\u00e7as Infecto-contagiosas (HDIC) em Teresina, Piau\u00ed. Identifica\u00e7\u00e3o de Reserv\u00e1rias nos Estados do Par\u00e1 e Maranh\u00e3o","author":"VERAS K. N.","year":"1995"},{"key":"ref41","series-title":"Paracoccidioidomicose: Inqu\u00e9rito Intrad\u00e9rmico em Zona Urbana do Munic\u00edpio do Rio de Janeiro","author":"WANKE B.","year":"1976"},{"key":"ref42","series-title":"Desafios em Ci\u00eancia e Tecnologia no Brasil. Emerg\u00eancia e Reemerg\u00eancia de Doen\u00e7as Infecciosas e Parasit\u00e1rias: Programa de Indu\u00e7\u00e3o Estrat\u00e9gica \u00e0 Pesquisa em Sa\u00fade","author":"WANKE B.","year":"1998"},{"key":"ref43","series-title":"Paracoccidioidomycosis","first-page":"109","volume-title":"Epidemiology and paracoccidioidomycosis infection","author":"WANKE B.","year":"1994"},{"key":"ref44","series-title":"Microbiology and Microbial Infections: Medical Mycology","first-page":"395","volume-title":"Paracoccidioides brasiliensis","volume":"4","author":"WANKE B.","year":"1998","edition":"9"}],"container-title":["Cadernos de Sa\u00fade P\u00fablica"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/csp\/v18n5\/11017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T19:08:33Z","timestamp":1587496113000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-311X2002000500037&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S0102-311X2002000500037"],"URL":"https:\/\/doi.org\/10.1590\/s0102-311x2002000500037","relation":{},"ISSN":["0102-311X"],"issn-type":[{"value":"0102-311X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}