{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:53:37Z","timestamp":1761310417456},"reference-count":46,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p>A regi\u00e3o de Passo Fundo no Planalto M\u00e9dio do Rio Grande do Sul, caracteriza-se pela produ\u00e7\u00e3o de gr\u00e3os (trigo, soja), nas quais grandes quantidades de agroqu\u00edmicos (fungicidas, inseticidas e herbicidas) s\u00e3o utilizadas. Para avaliar a atividade genot\u00f3xica desses produtos em seres humanos, utilizou-se a t\u00e9cnica de micron\u00facleos, atrav\u00e9s de amostras de sangue perif\u00e9rico de trinta trabalhadores expostos e de trinta indiv\u00edduos controles n\u00e3o expostos. A freq\u00fc\u00eancia de micron\u00facleos foi avaliada em 1.000 c\u00e9lulas binucleadas por indiv\u00edduo em ambos os grupos. Fatores como tabagismo, idade e tempo de exposi\u00e7\u00e3o n\u00e3o exerceram qualquer efeito sobre a freq\u00fc\u00eancia de micron\u00facleos em ambos os grupos. No entanto, a an\u00e1lise estat\u00edstica revelou n\u00fameros significativamente mais elevados de micron\u00facleos em expostos (14,3\/1.000 c\u00e9lulas) do que em n\u00e3o expostos (7,1\/1.000 c\u00e9lulas), indicando que o teste do micron\u00facleo \u00e9 um ensaio biol\u00f3gico eficiente para monitorar popula\u00e7\u00f5es expostas a misturas de agroqu\u00edmicos.<\/jats:p>","DOI":"10.1590\/s0102-311x2002000600022","type":"journal-article","created":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T20:30:55Z","timestamp":1178310655000},"page":"1675-1683","source":"Crossref","is-referenced-by-count":8,"title":["Instabilidade cromoss\u00f4mica induzida por agroqu\u00edmicos em trabalhadores rurais na regi\u00e3o de Passo Fundo, Rio Grande do Sul, Brasil"],"prefix":"10.1590","volume":"18","author":[{"given":"Adil de Oliveira","family":"Pacheco","sequence":"first","affiliation":[{"name":"Universidade de Passo Fundo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Hackel","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0027-5107(91)90203-Z","article-title":"Chromosome aberrations (CA), sister chromatid exchanges (SCE) and mitogen-induced blastogenesis in cultured peripheral lymphocytes from 48 control individuals sampled 8 times over 2 years","volume":"250","author":"ANDERSON D.","year":"1991","journal-title":"Mutation Research","ISSN":"http:\/\/id.crossref.org\/issn\/0027-5107","issn-type":"print"},{"key":"ref2","series-title":"BioEstat: Aplica\u00e7\u00f5es Estat\u00edsticas nas \u00c1reas das Ci\u00eancias Biol\u00f3gicas e M\u00e9dicas","author":"AYRES M.","year":"1998"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/(SICI)1098-2280(1998)31:3<228::AID-EM4>3.0.CO;2-G","article-title":"Sister chromatid exchange and micronucleus frequency in human lymphocytes of 1650 subjects in an Italian population: II. 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