{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:24:28Z","timestamp":1791113068423,"version":"4.1.0"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>Este trabalho teve como objetivo avaliar a validade e reprodutibilidade dos sinais cl\u00ednicos (palidez palmar e conjuntival) no diagn\u00f3stico de anemia em crian\u00e7as de 6-23 meses, no Nordeste do Brasil, por meio de estudo transversal com amostra de 421 crian\u00e7as, realizado nos ambulat\u00f3rios de pediatria e puericultura do Instituto Materno Infantil de Pernambuco. Os sinais cl\u00ednicos foram avaliados por dois examinadores. A reprodutibilidade foi avaliada pelo coeficiente de kappa e a valida\u00e7\u00e3o (sensibilidade e especificidade) foi realizada utilizando-se a hemoglobina como padr\u00e3o. Os sinais cl\u00ednicos demonstraram baixa reprodutibilidade (kappa de 0,24-0,25). A maior sensibilidade para diagnosticar anemia (Hb &lt; 11g\/dl) e anemia moderada\/ grave (Hb &lt; 9g\/dl), respectivamente, foi apresentada pela combina\u00e7\u00e3o de palidez palmar ou conjuntival (39,7% e 53,5%), seguida pela palidez palmar isoladamente (29,9% e 40,0%). A maior especificidade foi para a palidez palmar comparada \u00e0 palma da m\u00e3o da m\u00e3e (95,5% e 90,1% para Hb &lt; 11g\/dl e Hb &lt; 9g\/dl, respectivamente). A sensibilidade dos sinais cl\u00ednicos foi melhor para diagnosticar a anemia moderada\/grave, especialmente quando a palidez palmar e conjuntival s\u00e3o combinadas, sugerindo que a utiliza\u00e7\u00e3o dos mesmos n\u00e3o se constitui em um bom instrumento para diagnosticar anemia leve.<\/jats:p>","DOI":"10.1590\/s0102-311x2005000200023","type":"journal-article","created":{"date-parts":[[2005,4,19]],"date-time":"2005-04-19T19:56:40Z","timestamp":1113940600000},"page":"565-572","source":"Crossref","is-referenced-by-count":10,"title":["Valida\u00e7\u00e3o e reprodutibilidade de sinais cl\u00ednicos no diagn\u00f3stico de anemia em crian\u00e7as"],"prefix":"10.1590","volume":"21","author":[{"given":"Luciana Pedrosa","family":"Leal","sequence":"first","affiliation":[{"name":"Universidade Federal de Pernambuco, Brasil; Universidade Federal de Pernambuco, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Maria","family":"Os\u00f3rio","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"A guide for programme managers","author":"World Health Organization\/United Nations Children's Fund\/United Nations University. 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