{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:20:30Z","timestamp":1780489230563,"version":"3.54.1"},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>BACKGROUND: Partial portal vein ligation causes an increase in portal pressure that remains stable even after the appearance of collateral circulation, with functional adaptation to prolonged decrease in portal blood flow. AIM: To assess whether different constriction rates produced by partial ligation of the vein interfere with the results of this experimental model in rats. METHODS: Three groups of five rats each were used; in group 1 (sham-operated), dissection and measurement of portal vein diameters were performed. Portal hypertension was induced by partial portal vein ligation, reducing its size to 0.9 mm in the remaining 10 animals, regardless of the initial diameter of the veins. Five animals with portal hypertension (group 2) underwent reoperation after 15 days and the rats in group 3 after 30 days. The calculation of the constriction rate was performed using a specific mathematical formula (1 - \u03c0 r 2 \/ \u03c0 R2) x 100% and the statistical analysis with the Student t test. RESULTS: The initial diameter of the animal's portal vein was 2.06 mm, with an average constriction rate of the 55.88%; although the diameter of the veins and the constriction rate in group 2 were lower than in group 3 (2.06 mm - 55,25% and 2.08 mm - 56.51%, respectively), portal hypertension was induced in all rats and no significant macroscopic differences were found between the animals that were reoperated after 15 days and after 30 days respectively, being the shorter period considered enough for the evaluation. Comparing the initial diameter of the vein and the rate of constriction performed in groups 2 and 3, no statistic significance was found (p&gt;0.05). CONCLUSION: Pre-hepatic portal hypertension in rat can be induced by the reduction of the portal vein diameter to 0.9 mm, regardless the initial diameter of the vein and the vessel constriction rate.<\/jats:p>","DOI":"10.1590\/s0102-67202014000400012","type":"journal-article","created":{"date-parts":[[2015,1,24]],"date-time":"2015-01-24T15:44:03Z","timestamp":1422114243000},"page":"280-284","source":"Crossref","is-referenced-by-count":9,"title":["Constriction rate variation produced by partial ligation of the portal vein at pre-hepatic portal hypertension induced in rats"],"prefix":"10.1590","volume":"27","author":[{"given":"Daren Athi\u00ea Boy","family":"RODRIGUES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Riquena da","family":"SILVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Carvalho","family":"SERIGIOLLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramiro de Sousa","family":"FIDALGO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio San Gregorio","family":"FAVERO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Luiz Squilacci","family":"LEME","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/203794","article-title":"Clinical manifestations of portal hypertension","volume":"2012","author":"Al-Busafi SA","year":"2012","journal-title":"Int J Hepatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1590\/S0100-69912005000400011","article-title":"Modelo experimental de forma\u00e7\u00e3o de varizes esof\u00e1gicas por hipertens\u00e3o portal esquistossom\u00f3tica em hamsters","volume":"32","author":"Assef AJ","year":"2005","journal-title":"Rev Col Bras Cir"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0022-3468(80)80287-9","article-title":"Experimental portal hypertension in the rat","volume":"15","author":"Canty TG","year":"1980","journal-title":"J Pediatr Surg"},{"key":"ref4","first-page":"137","article-title":"Long-term portal hypertension in the rat by means of triple stenotic ligation of the portal vein","volume":"17","author":"Fabi\u00e1n GR","year":"2000","journal-title":"An Med Interna"},{"issue":"4","key":"ref5","first-page":"S36","article-title":"Trombose de veia porta em crian\u00e7as e adolescentes: revis\u00e3o de literatura","volume":"21","author":"Ferri PM","year":"2011","journal-title":"Rev Med Minas Gerais"},{"key":"ref6","first-page":"305","article-title":"Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat","volume":"65","author":"Kountouras J","year":"1984","journal-title":"Br J Exp Path"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S1665-2681(19)31522-4","article-title":"Glutamine prevents gastric oxidative stress in an animal model of portal hypertension gastropathy","volume":"10","author":"Marques C","year":"2011","journal-title":"Ann Hepatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11605-006-0063-1","article-title":"Partial portal vein ligation plus thioacetamide: a method to obtain a new model of cirrhosis and chronic portal hypertension in the rat","volume":"11","author":"M\u00e9ndez-L\u00f3pez M","year":"2007","journal-title":"J Gastrointest Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3350\/cmh.2012.18.2.178","article-title":"A clinical predictor of varices and portal hypertensive gastropathy in patients with chronic liver disease","volume":"18","author":"Min YW","year":"2012","journal-title":"Clin Mol Hepatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1590\/S0004-28032011000300011","article-title":"Protection of estrogen in portal hypertension gastropathy - an experimental model","volume":"48","author":"Morgan-Martins MI","year":"2011","journal-title":"Arq Gastroenterol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000128006","article-title":"Self-established porto-caval and porto-pulmonary shunts in mechanically induced portal hypertension. 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