{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:45:54Z","timestamp":1707511554462},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>OBJETIVO: Avaliar, do ponto de vista histol\u00f3gico, a a\u00e7\u00e3o do extrato aquoso da aroeira-do-sert\u00e3o na cicatriza\u00e7\u00e3o da anastomose col\u00f4nica, em ratos Wistar. M\u00c9TODOS: Foram utilizados 48 ratos da linhagem Wistar, machos, com peso m\u00e9dio de 320g, distribu\u00eddos em dois grupos, com 24 animais, cada. Todos os animais foram submetidos \u00e0 sec\u00e7\u00e3o transversa completa do c\u00f3lon descendente, seguida de anastomose col\u00f4nica. Os ratos do grupo A receberam diariamente no p\u00f3s-operat\u00f3rio enemas de ve\u00edculo \u00e0 base de carboximetilcelulose (CMC). Os animais do grupo B receberam no p\u00f3s-operat\u00f3rio enemas de extrato aquoso de aroeira-do-sert\u00e3o a 10% em ve\u00edculo \u00e0 base de CMC, at\u00e9 a data da eutan\u00e1sia. Nas datas 3, 7, 14 e 21 do experimento, seis ratos de cada grupo foram submetidos \u00e0 remo\u00e7\u00e3o de segmento col\u00f4nico, incluindo a anastomose, destinado \u00e0 aprecia\u00e7\u00e3o histol\u00f3gica e an\u00e1lise qualitativa da resposta celular inflamat\u00f3ria e cicatricial. RESULTADOS: A an\u00e1lise morfol\u00f3gica revela diferen\u00e7a significante entre os grupos, no dia 7 (\u00f1 &lt; 0,05), quando o grupo estudado apresentou menor escore que o grupo controle. A deposi\u00e7\u00e3o do col\u00e1geno no grupo aroeira foi menor, nos dias 3, 7 e 14 (\u00f1 &lt; 0,05), em rela\u00e7\u00e3o ao grupo controle. CONCLUS\u00c3O: O extrato aquoso da aroeira-do-sert\u00e3o tem a\u00e7\u00e3o antiinflamat\u00f3ria. Tamb\u00e9m possui efeito inibit\u00f3rio na deposi\u00e7\u00e3o do col\u00e1geno nas fases inflamat\u00f3ria e de fibroplasia no processo cicatricial de anastomoses col\u00f4nicas, em ratos Wistar, por\u00e9m em fases avan\u00e7adas (dia 21) a cicatriza\u00e7\u00e3o se d\u00e1 de forma semelhante aos animais do grupo controle.<\/jats:p>","DOI":"10.1590\/s0102-86502005000200008","type":"journal-article","created":{"date-parts":[[2006,1,10]],"date-time":"2006-01-10T11:12:58Z","timestamp":1136891578000},"page":"144-151","source":"Crossref","is-referenced-by-count":12,"title":["An\u00e1lise histol\u00f3gica da cicatriza\u00e7\u00e3o da anastomose col\u00f4nica, em ratos, sob a\u00e7\u00e3o de enema de Aroeira-do-sert\u00e3o (Myracrodruon urundeuva fr. all.) a 10%"],"prefix":"10.1590","volume":"20","author":[{"given":"Annya Costa Ara\u00fajo de Macedo","family":"Goes","sequence":"first","affiliation":[{"name":"UFC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lusmar Veras","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"UFC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalgimar Beserra de","family":"Menezes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Patroc\u00ednio Ferreira","family":"Grangeiro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio Rubens Martins Soares","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"UFC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jpedsurg.2003.12.017","article-title":"Sustained local application of low-dose epidermal growth factor on steroid-inhibited colonic wound healing","volume":"39","author":"Sakallioglu A.E.","year":"1994","journal-title":"J. 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