{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:26:01Z","timestamp":1759728361174},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p>PURPOSE: To test if a water extract of Coleus barbatus (WEB) has any effect on weight gain, food energy utilization and lipid metabolism in young rats with obstructive cholestasis. METHODS: Forty 21 day old (P21) Wistar rats, in groups of 10, were submitted to one of the following treatments: a sham operation with daily water or WEB administration, double ligature and resection of the bile duct with daily water or WEB administration. At P49 they were submitted for euthanasia when the following were determined: ingested feed (IF), energy utilization (EU) and weight gain (WG) from P29 to P49, together with total serum cholesterol (TC) and triacylglycerol (TG) concentrations, liver wet weight (LWW) and fat content (LFC). Two Way ANOVA and the S.N.K. test for paired comparisons were employed to study the effects of cholestasis and those of WEB and their interactions (p&lt;0.05). RESULTS: Cholestasis, independently of WEB, and WEB, independently of cholestasis both reduced IF, EU, and WG, but there was no significant interaction between the two factors. Cholestasis, independently of WEB, increased LWW, LFC, the TC and TG. The WEB, independently of cholestasis, reduced these values, and there was a significant interaction between the two factors; such that these effects were more accentuated in animals with cholestasis. CONCLUSION: The WEB reduced IF, WG, and EU, both in the presence and absence of cholestasis in the same proportion. It also partially inhibited the increase in LWW, LFC, TC and TG caused by cholestasis.<\/jats:p>","DOI":"10.1590\/s0102-86502005000300007","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T18:51:26Z","timestamp":1136832686000},"page":"229-236","source":"Crossref","is-referenced-by-count":4,"title":["Water-soluble extract of Coleus barbatus modulates weight gain, energy utilization and lipid metabolism in secondary biliary cirrhosis: an experimental study in young rats"],"prefix":"10.1590","volume":"20","author":[{"given":"Ana Paula Ronquesel","family":"Battochio","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University. UNESP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Salete","family":"Sartori","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University. UNESP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udio Ant\u00f4nio Rabello","family":"Coelho","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1034\/j.1399-3046.2002.01082.x","article-title":"History of pediatric liver transplantation: Where are we coming from? Where do we stand?","volume":"6","author":"Otte JB","year":"2002","journal-title":"Pediatr Transplant."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/jn\/121.9.1447","article-title":"Increased dietary branched-chain amino acids do not improve growth in developing rats with chronic biliary obstruction","volume":"121","author":"Weisdorf SA","year":"1991","journal-title":"J Nutr."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/path.1700350512","article-title":"Ligation of the common bile duct","volume":"35","author":"Cameron GR","year":"1932","journal-title":"J Pathol Bacteriol."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/BF02722636","article-title":"Nutrition management in chronic liver disease","volume":"69","author":"Bavdekar A","year":"2002","journal-title":"Indian J Pediatr."},{"key":"ref5","first-page":"331","article-title":"Decreased bone mineral density and gene polymorphism in primary biliary cirrhosis","volume":"145","author":"Lakatos PL","year":"2004","journal-title":"Orv Hetil","ISSN":"http:\/\/id.crossref.org\/issn\/0030-6002","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1136\/gut.13.9.682","article-title":"Lipid absorption, bile acids and cholesterol metabolism in patients with chronic liver disease","volume":"13","author":"Miettinen TA.","year":"1972","journal-title":"Gut."},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1042\/bj1240056Pa","article-title":"Lipid metabolism in experimental cholestasis","volume":"124","author":"Record CO","year":"1971","journal-title":"Biochem J."},{"key":"ref8","first-page":"38","article-title":"Use of a specific cholecystokinin receptor antagonist (L-364,718) to determine the role of cholecystokinin on feeding and body weight in rats with obstructive jaundice.","volume":"3","author":"Tangoku A","year":"1992","journal-title":"J Assoc Acad Minor Phys."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1023\/A:1013248427783","article-title":"Alterations in serum leptin in chronic liver disease","volume":"47","author":"Ben-Ari Z","year":"2002","journal-title":"Dig Dis Sci."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/ajcn\/69.6.1066","article-title":"Effect of cirrhosis on energy expenditure","volume":"69","author":"McCullough JA","year":"1999","journal-title":"Am J Clin Nutr."},{"key":"ref11","first-page":"6","article-title":"Infant cholestasis Advances in its understanding: new concepts","volume":"41","author":"Tomar BS","year":"2000","journal-title":"Acta Paediatr Taiwan."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3109\/00365528809090155","article-title":"Serum cholesterol precursors, cholestanol, and plant sterols in primary biliary cirrhosis","volume":"23","author":"Nikkil\u00e4 K","year":"1988","journal-title":"Scand J Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0036-5521","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0022-3476(05)81079-0","article-title":"Resistance to the growth promoting and metabolic effects of hormone in children with chronic liver disease","volume":"117","author":"Bucuvalas JC","year":"1990","journal-title":"J Pediatr."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0344-0338(83)80080-6","article-title":"Liver biopsy interpretation in hepatitis: Part I. Presentation of critical morphology features used in diagnosis (glossary)","volume":"178","author":"Bianchi L.","year":"1983","journal-title":"Pathol Res Pract."},{"key":"ref15","series-title":"Herbarium: Comp\u00eandio de Fitoterapia","author":"Teske M","year":"1997","edition":"3"},{"key":"ref16","series-title":"Manual para t\u00e9cnica em bioterismo","year":"1996"},{"key":"ref17","series-title":"Guide do the Care and Use of Experimental Animals","volume":"1 and 2","year":"1984"},{"key":"ref18","first-page":"95","article-title":"Import\u00e2ncia da cor da ra\u00e7\u00e3o no consumo da mesma por ratos (Ratus norvegicus var albinus).","volume":"7","author":"Lajolo FM","year":"1969","journal-title":"Rev Fac Farm Bioquim."},{"key":"ref19","first-page":"242","article-title":"Salt mixtures for purifield type diets III Na improved salt mixtures for chicks","volume":"72","author":"Fox MRS","year":"1960","journal-title":"J Nutr."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1590\/S0102-86502004000100012","article-title":"Adapta\u00e7\u00e3o do modelo experimental de colestase extra-hep\u00e1tica em ratos jovens","volume":"19","author":"Battochio APR","year":"2004","journal-title":"Acta Cir Bras."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/taap.2002.9367","article-title":"Salvia miltiorrhiza inhibits biliary obstruction-induced hepatocyte apoptosis by cytoplasmic sequestration of p53","volume":"182","author":"Oh SH","year":"2002","journal-title":"Toxicol Appl Pharmacol."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1152\/ajpgi.00008.2003","article-title":"Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats.","volume":"285","author":"Zhong Z","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1034\/j.1600-0773.2000.pto870604.x","article-title":"Effect of tetrandrine on experimental hepatic fibrosis induced by bile duct ligation and scission in rats","volume":"87","author":"Park PH","year":"2000","journal-title":"Pharmacol Toxicol."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/ajcn\/44.3.362","article-title":"Changes in nutritional status associated with obstructive jaundice and biliary drainage in rats","volume":"44","author":"Gouma DJ","year":"1986","journal-title":"Am J Clin Nutr."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1203\/00006450-199607000-00012","article-title":"Branched chain amino acids improve body composition and nitrogen balance in a rat model of extra hepatic biliary atresia","volume":"40","author":"Sokal EM","year":"1996","journal-title":"Pediatr Res."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0378-8741(00)00275-0","article-title":"The toxics effects of Coleus barbatus B. on the different periods of pregnancy in rats","volume":"73","author":"Almeida FCG","year":"2000","journal-title":"J Ethnopharmacol","ISSN":"http:\/\/id.crossref.org\/issn\/0378-8741","issn-type":"print"},{"key":"ref27","first-page":"109","article-title":"Experimental models of hepatic fibrosis in the rat","volume":"28","author":"Wasser S","year":"1999","journal-title":"Ann Acad Med Singapore","ISSN":"http:\/\/id.crossref.org\/issn\/0304-4602","issn-type":"print"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000046731","article-title":"Fat absorption and metabolism in bile duct ligated rats","volume":"45","author":"De Vriese SR","year":"2001","journal-title":"Ann Nutr Metab."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0016-5085(74)80047-8","article-title":"Studies of hepatic cholesterol synthesis in experimental acute biliary obstruction","volume":"66","author":"Cooper AD","year":"1974","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"}],"container-title":["Acta Cirurgica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/acb\/v20n3\/a07v20n3.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T01:16:32Z","timestamp":1586654192000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502005000300007&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0102-86502005000300007"],"URL":"https:\/\/doi.org\/10.1590\/s0102-86502005000300007","relation":{},"ISSN":["0102-8650"],"issn-type":[{"value":"0102-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}