{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T11:07:01Z","timestamp":1649156821419},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>PURPOSE: The labeling of red blood cells (C) with 99mTc is employed in clinical nuclear medicine for a variety of diagnostic procedures. Drugs can alter this labeling method and modify the disposition of the radiopharmaceuticals. In this paper, the influence of glucantime on the labeling of blood constituents with 99mTc was reported. METHODS: Blood was withdrawn from rats and incubated with glucantime. Stannous chloride and 99mTc were added. After centrifugation, plasma (P) and (C) were isolated. Samples of P and C were precipitated with TCA 5%, centrifuged and insoluble (IF) and soluble fractions (SF) separated. The percentages of total activity injected (%ATI) in C, IF-P and IF-C were calculated (p&lt;0.05). RESULTS: The %ATI on C decreased from control to following concentrations of glucantime (6.25%;12.5%;25%;50%;100%), respectively: 94.06\u00b11.29 (control) to 77.15\u00b12.79; to 76.68\u00b11.88; to 75.15\u00b12.79; to 72.64\u00b14.40 and to 63.05\u00b13.84. On IF-C the %ATI decreased from control to all the concentrations of glucantime (3.125%;6.25%;12.5%;25%;50%; 100%), respectively: 93.34\u00b11.18 (control) to 78.81\u00b12.76; to 74.76\u00b14.82; to 74.02\u00b15.32; to 64.35\u00b14.82; to 62.81\u00b11.97 and to 54.55\u00b13.58. CONCLUSIONS: This effect was probably due to products present in this drug that may complex with ions (Sn+2 and 99mTcO-4) or have a direct or indirect effect on intracellular stannous ion concentration.<\/jats:p>","DOI":"10.1590\/s0102-86502005000700015","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T18:33:47Z","timestamp":1136831627000},"page":"81-85","source":"Crossref","is-referenced-by-count":3,"title":["The effect of glucantime\u2122 on the labeling of blood constituents with technetium-99m"],"prefix":"10.1590","volume":"20","author":[{"given":"Cec\u00edlia Maria Carvalho Xavier","family":"Holanda","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Carvalho Holanda","family":"Leite","sequence":"additional","affiliation":[{"name":"UFRN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa Jansem","family":"Catanho","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Maria Lima","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio","family":"Bernardo Filho","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/clind\/24.4.684","article-title":"Human leishmaniasis: clinical, diagnostic and chemotherapeutic developments in the last 10 years (review article)","volume":"24","author":"Berman JD","year":"1997","journal-title":"Clin Infect Dis","ISSN":"http:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"key":"ref2","series-title":"World Health 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Med","ISSN":"http:\/\/id.crossref.org\/issn\/0340-6997","issn-type":"print"},{"key":"ref11","first-page":"222","article-title":"High RBC labeling efficiency by controlling pretinning with the modified in vivo, in vitro labeling method","volume":"27","author":"Kuehne R","year":"1999","journal-title":"J Nucl Biol Med Technol"},{"key":"ref12","first-page":"2004","article-title":"Radiolabeling of erythrocytes with technetium-99m: role of band-3 protein in the transport of pertechnetate across the cell membrane","volume":"31","author":"Callahan RJ","year":"1990","journal-title":"J Nucl Med","ISSN":"http:\/\/id.crossref.org\/issn\/0161-5505","issn-type":"print"},{"key":"ref13","first-page":"761","article-title":"Effects of the glucantime on the kinetic of biodistribution of radiopharmaceuticals in Wistar rats","volume":"48","author":"Holanda CMCX","year":"2002","journal-title":"Cell Mol Biol","ISSN":"http:\/\/id.crossref.org\/issn\/0145-5680","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1128\/AAC.42.5.1076","article-title":"Characterization of the antimonial antileishmanial agent meglumine antimonate (glucantime)","volume":"42","author":"Roberts WL","year":"1998","journal-title":"Antim Agent Chemoth"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0378-8741(00)00240-3","article-title":"Assessment of the effect of Maytenus ilicifolia (espinheira santa) extract on the labeling of red blood cells and plasma proteins with technetium-99m","volume":"72","author":"Oliveira JF","year":"2000","journal-title":"J Ethnopharm"},{"key":"ref16","first-page":"305","article-title":"Effect of extract of medicinal plants on the labeling of blood elements with technetium-99m and on the morphology of red blood cells","volume":"73","author":"Oliveira JF","year":"2002","journal-title":"I. A study with Paullinia cupana. Fitoterapia"}],"container-title":["Acta Cirurgica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/acb\/v20s1\/25573.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T03:15:17Z","timestamp":1555211717000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502005000700015&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":16,"journal-issue":{"issue":"suppl 1","published-print":{"date-parts":[[2005]]}},"alternative-id":["S0102-86502005000700015"],"URL":"https:\/\/doi.org\/10.1590\/s0102-86502005000700015","relation":{},"ISSN":["0102-8650"],"issn-type":[{"value":"0102-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}