{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T22:30:15Z","timestamp":1648938615876},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>PURPOSE: To analyze mucosal proliferation and its characteristics, through specific models of duodenogastric reflux, in the stomach of Wistar rats. METHODS: Seventy-five healthy and adult male rats were divided into three groups: group I - control (n = 25 animals), submitted to gastrotomy of the posterior wall of the glandular stomach; group II - DGR (n = 25 animals), submitted to duodenogastric reflux through latero-lateral gastrojejunal anastomosis in the posterior wall of the glandular stomach and group III - DGR-P (n = 25 animals), submitted to duodenogastric reflux through the pylorus following the same procedure of group II, sectioning and closing the afferent loop. The animals were observed during 36 weeks and subsequently the mucosal lesions were analyzed, with macroscopic and microscopic examination of the prepyloric, the gastrojejunostomy and the squamous area of the stomach. RESULTS: Group I did not present any kind of lesion. Macroscopic lesions of the prepyloric area in groups II and III were 0% and 20%, respectively. Macroscopic lesions of the gastrojejunal stoma in groups II and III were 36% and 88%, respectively, and 12% and 28%, respectively, in the squamous area. Microscopically, adenomatous hyperplasia (AH), squamous hyperplasia (SH) and adenocarcinoma (AC) were diagnosed. The occurrence of AH at the prepyloric area in groups II and III was 0% and 40%, respectively, and in the gastrojejunal stoma, 40% and 72%, respectively. The occurrence of SH in the squamous area in groups II and III was 12% and 20%, respectively, without statistical differences between the groups. AC was found only in three animals of groups III (12%). CONCLUSIONS: The duodenogastric reflux in this experimental model caused high frequency of proliferative lesions of the gastrojejunal stoma and in the prepyloric area, while adenocarcinoma was a rare occurrence.<\/jats:p>","DOI":"10.1590\/s0102-86502006000400004","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T17:41:01Z","timestamp":1154540461000},"page":"207-213","source":"Crossref","is-referenced-by-count":1,"title":["Gastric proliferative lesions induced by duodenogastric reflux in rats"],"prefix":"10.1590","volume":"21","author":[{"given":"Ros\u00e2ngela Lucinda Rocha","family":"Monteiro","sequence":"first","affiliation":[{"name":"University of Vale do Sapuca\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson Adami","family":"Andreollo","sequence":"additional","affiliation":[{"name":"UNICAMP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida Marchesan","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Raquel","family":"Araujo","sequence":"additional","affiliation":[{"name":"UNICAMP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/carcin\/13.12.2313","article-title":"Duodenal reflux trought the pylorus induces gastric adenocarcinoma in the rat","volume":"13","author":"Miwa K","year":"1992","journal-title":"Carcinogenesis","ISSN":"http:\/\/id.crossref.org\/issn\/0143-3334","issn-type":"print"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1023\/B:DDAS.0000004519.26201.a4","article-title":"Gastric carcinogenesis by duodenal reflux through gut regenerative cell lineage","volume":"48","author":"Mukaisho K","year":"2003","journal-title":"Dig Dis Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0163-2116","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/bjs.1800740421","article-title":"Effect of duodenogastric reflux on gastric mucosal proliferation after gastric surgery","volume":"74","author":"Houghton PWJ","year":"1987","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"},{"issue":"3","key":"ref4","first-page":"103","article-title":"Are the nitrites and nitrates responsible for the carcinoma in the operated stomach ?","volume":"10","author":"Andreollo NA","year":"1995","journal-title":"Acta Cir Bras"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/01.sla.0000150072.55037.e3","article-title":"The mutagenic potential of duodenoesophageal reflux","volume":"241","author":"Theisen J","year":"2005","journal-title":"Ann Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0003-4932","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0140-6736(86)91041-X","article-title":"Mortality from gastric cancer following gastric surgery for peptic ulcer","volume":"1","author":"Cayagill CPJ","year":"1986","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1056\/NEJM198807283190402","article-title":"Stomach cancer after partial gastrectomy for benign ulcer disease","volume":"319","author":"Lundegardh G","year":"1988","journal-title":"N Engl J Med","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1136\/gut.29.11.1588","article-title":"Mortality caused by stomach cancer after remote partial gastrectomy for benign conditions: 40 years of follow-up of an Amsterdam cohort of 2633 postgastrectomy patients","volume":"29","author":"Tersmette KWF","year":"1988","journal-title":"Gut","ISSN":"http:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00000658-198908000-00004","article-title":"Gastric cancer after peptic ulcer surgery: a historic prospective cohort investigation","volume":"210","author":"Toftgaard C","year":"1989","journal-title":"Ann Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0003-4932","issn-type":"print"},{"key":"ref10","first-page":"503","article-title":"Duodenoesophageal reflux and development of esophageal adenocarcinoma in rats","volume":"111","author":"Attwood SEA","year":"1992","journal-title":"Surgery","ISSN":"http:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/bjc.1994.277","article-title":"Induction of oesophageal and forestomach carcinomas in rats by reflux of duodenal contents","volume":"70","author":"Miwa K","year":"1994","journal-title":"Br J Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0007-0920","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/1097-0142(19950315)75:6+<1426::AID-CNCR2820751506>3.0.CO;2-#","article-title":"Duodenogastric reflux and foregut carcinogenesis","volume":"75","author":"Miwa K","year":"1995","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2982.2004.00633.x","article-title":"Mechanisms underlying duodeno-gastric reflux in man","volume":"17","author":"Koek GH","year":"2005","journal-title":"Neurogastroenterol Motil","ISSN":"http:\/\/id.crossref.org\/issn\/1350-1925","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/jcp.46.3.235","article-title":"Bile reflux 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em Y de Roux, em ratos","author":"Saad LHC","year":"1993"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/carcin\/12.8.1437","article-title":"Reversibility of adenomatous hyperplasia in the gastric stump after diversion of the bile reflux in rats","volume":"12","author":"Kobayasi S","year":"1991","journal-title":"Carcinogenesis","ISSN":"http:\/\/id.crossref.org\/issn\/0143-3334","issn-type":"print"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1590\/S0102-86502002000300003","article-title":"O refluxo duodeno-g\u00e1strico (RDG), atrav\u00e9s do piloro, induz les\u00f5es proliferativas g\u00e1stricas em ratos ?","volume":"17","author":"Rodrigues PA","year":"2002","journal-title":"Acta Cir Bras"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/jsre.2002.6501","article-title":"Ulceration as a possible link between duodenogastric reflux and neoplasms in the stomach of 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