{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:33:36Z","timestamp":1760888016538},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>PURPOSE: To investigate the effect of oral glutamine alone or combined with short chain fatty acids (SCFA) in the intestinal adaptation of rats submitted to an massive enterectomy. METHODS: After receiving 70% small bowel resection, 30 Wistar rats were randomized to received either standard rat chow (control group, n=10) or the same diet supplemented with 3,05% of glutamine alone (glutamine group, n=10) or combined with a solution containing SCFA (glutamine+SCFA group, n=10). Animals were killed on the 14th postoperative day. Mucosal weight, crypt depth, villus height, wall width, and the mucosal content of DNA, were assessed in basal conditions (resected gut specimen) and compared to the small bowel specimen collected on the postoperative day 14, at both jejunum and ileum sites. RESULTS: All groups presented similar pattern in weight evolution. In all groups, both the morphological findings and the DNA content were significantly higher at the end of the experiment than in basal conditions, at both the jejunum and ileum. Except for the jejunum wall width that was higher in control group (808\u00b195 \u00b5) than in the other two groups (glutamine = 649\u00b188 \u00b5 and glutamine+SCFA = 656\u00b192; p&lt;0.01), there was no difference among them in all variables at both intestinal sites after 14 days. CONCLUSION: All groups presented adaptation of the intestinal mucosa in the remnant gut. Glutamine combined or not with short chain fatty acids fails to influence the adaptive response of the small bowel.<\/jats:p>","DOI":"10.1590\/s0102-86502006001000002","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T12:44:05Z","timestamp":1173962645000},"page":"2-7","source":"Crossref","is-referenced-by-count":8,"title":["Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats&lt;A NAME=\"volta1\"&gt;&lt;\/A&gt;"],"prefix":"10.1590","volume":"21","author":[{"given":"Jos\u00e9 de Souza","family":"Neves","sequence":"first","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Eduardo de","family":"Aguilar-Nascimento","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Helena Gaiva","family":"Gomes-da-Silva","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosec\u00e9lia Nunes","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Salom\u00e3o","family":"Bicudo","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubens Jardim","family":"Nochi Jr.","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s003830000443","article-title":"Effects of intrinsic denervation on intestinal morphology in rats with short-bowel syndrome","volume":"16","author":"Sencan A","year":"2000","journal-title":"Pediatr Surg Int","ISSN":"http:\/\/id.crossref.org\/issn\/0179-0358","issn-type":"print"},{"key":"ref2","first-page":"135","article-title":"Surgical management of short-bowel syndrome","volume":"10","author":"Iglesias ACRG","year":"1995","journal-title":"Acta Cir Bras"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0039-6109(16)45438-1","article-title":"Management of short bowel syndrome","volume":"71","author":"Dudrick SJ","year":"1991","journal-title":"Surg Clin North Am","ISSN":"http:\/\/id.crossref.org\/issn\/0039-6109","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/0148607186010004343","article-title":"The effect of a pectin-supplemented elemental diet on intestinal adaptation to massive small bowel resection","volume":"10","author":"Koruda MJ","year":"1986","journal-title":"J Parenter Enteral Nutr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0889-8553(05)70014-5","article-title":"Short-bowel syndrome","volume":"37","author":"Scolapio JS","year":"1998","journal-title":"Gastroenterol Clin North Am","ISSN":"http:\/\/id.crossref.org\/issn\/0889-8553","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S0016-5085(76)80261-2","article-title":"Effects of oral versus intravenous nutrition on intestinal adaptation after small bowel resection in dog","volume":"70","author":"Feldman EJ","year":"1976","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1152\/physrev.1990.70.2.567","article-title":"Energy contributions of volatile fatty acids from the gastrointestinal tract in various species","volume":"70","author":"Bergman EN","year":"1990","journal-title":"Physiol Rev","ISSN":"http:\/\/id.crossref.org\/issn\/0031-9333","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1365-2036.1998.00337.x","article-title":"Review article: short-chain fatty acids in health and disease","volume":"12","author":"Cook SI","year":"1998","journal-title":"Aliment Pharmaco. 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