{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T05:06:26Z","timestamp":1737522386867,"version":"3.33.0"},"reference-count":60,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>PURPOSE: To compare, by continuous infusion of ketamine or medetomidine combined to methotrimeprazine and buprenorphine, ketamine and midazolam, the degree of hypnosis, myorelaxation, anesthetic quality and surgical feasibility through evaluation of possible parametric alterations and recovery quality. METHODS: 20 healthy adult females dogs, aged 3 to 5 years, body weight between 7 and 15 kg, were assigned randomly and homogenously to 2 groups of 10 animals each (n=10), group 1 (G1) and group 2 (G2), respectively. Animals of G1 were subjected to a pre-treatment with intravenous 1.0 mg\/kg methotrimeprazine and or 3\u00ec\/kg. After 15 minutes, a 5.0 mg\/kg ketamine and 0.2 mg\/kg midazolam were intravenously injected. Immediately after induction, an anesthetic combination of 0.4 mg\/kg\/h midazolam, 20 mg\/kg\/h ketamine and 1.0 mg\/kg\/h xylazine, was continuously and intravenously administered for 30 minutes. The same techniques were used in G2 except for the substitution of xylazine for 30\u00ecg\/kg\/h medetomidine. RESULTS: In G1 there was a 1st and 2nd degree atrioventricular heart block, a longer recovery period and lower quality. In G2 a 1st degree atrioventricular heart block occurred but isolated and ephemeral. CONCLUSIONS: The continuous infusion method, besides reducing drugs utilization, prevented collateral effects allowing a more tranquil recovery with no excitations, both protocols permitted the surgical procedure (ovary-hysterectomy) bringing about a reduction in hypnosis and an accentuated myorelaxation. Xylazine and medetomidine showed a similar pharmacodynamic behavior but with different clinical aspects. The electrocardiographic alterations observed in G2 and in a lower degree in G1 must be well studied. Describers: dogs, ketamine, methotrimeprazine, medetomidine, midazolam and xylazine.<\/jats:p>","DOI":"10.1590\/s0102-86502007000400008","type":"journal-article","created":{"date-parts":[[2007,9,27]],"date-time":"2007-09-27T22:56:35Z","timestamp":1190933795000},"page":"272-278","source":"Crossref","is-referenced-by-count":6,"title":["Continuous infusion in adult females dogs submitted to ovariohysterectomy with midazolam-xylazine and\/or medetomidine pre-treated with methotrimeprazine and buprenorphine"],"prefix":"10.1590","volume":"22","author":[{"given":"Fernando do Carmo","family":"Silva","sequence":"first","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Hatschbach","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo Feio da Maia","family":"Lima","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri Karaccas de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Massone","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"161","key":"ref1","first-page":"137","article-title":"An\u00e1lise de medidas repetidas em experimentos biol\u00f3gicos","volume":"41","author":"Curi PR","year":"1980","journal-title":"Rev Bras Estat."},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1590\/S0102-86502006000500006","article-title":"Parametric evaluation of methotrimeprazine-midazolam-ketamina and methotrimeprazine-midazolam-ketamina-xilazine combination in dogs","volume":"21","author":"Santos GJVG","year":"2006","journal-title":"Acta Cir Bras."},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0007-1935(96)80005-4","article-title":"Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose","volume":"152","author":"Cullen LK","year":"1996","journal-title":"Br Vet J."},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1590\/S0103-84782006000200027","article-title":"Parametria da associa\u00e7\u00e3o do midazolam ou diazepam em c\u00e3es pr\u00e9-tratados pela atropina e tratados pela dexmedetomidina e quetamina","volume":"36","author":"Hatschbach E","year":"2006","journal-title":"Ci\u00eanc Rural"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/vr.138.6.128","article-title":"Clinical comparison of medetomidina with xylazine\/I-methadone in dogs","volume":"138","author":"Kramer S","year":"1996","journal-title":"Vet Rec","ISSN":"https:\/\/id.crossref.org\/issn\/0042-4900","issn-type":"print"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2460\/javma.1998.213.02.215","article-title":"Effects of a microdose of medetomidina on diazepam-ketamina induced anesthesia in dogs","volume":"213","author":"Ko JC","year":"1998","journal-title":"J Am Vet Med Assoc."},{"issue":"11","key":"ref7","first-page":"887","article-title":"A review of the physiological effects of a2-agonists related to the clinical use of medetomidine in small animal pratice","volume":"44","author":"Sinclair MD","year":"2003","journal-title":"Can Vet J."},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1751-0813.1999.tb12907.x","article-title":"Advantages and disadvantages of using a-2 agonists in veterinary pratice","volume":"77","author":"Dart CM","year":"1999","journal-title":"Aust Vet J."},{"issue":"1","key":"ref9","first-page":"34","article-title":"Estudo da romifidina ou xilazina associadas \u00e0 cetamina em c\u00e3es pr\u00e9-tratados com atropina, submetidos ou n\u00e3o \u00e0 ov\u00e1rio-histerectomia","volume":"10","author":"Luna SPL","year":"2003","journal-title":"Rev Bras Cienc Vet."},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1590\/S0103-84781998000100011","article-title":"Levomepromazina e atropine como medica\u00e7\u00f5es pr\u00e9-anest\u00e9sicas na anestesia pela associa\u00e7\u00e3o tiletamina\/zolazepam, em c\u00e3es","volume":"28","author":"Pompermayer LG","year":"1998","journal-title":"Ci\u00eanc Rural."},{"issue":"2","key":"ref11","first-page":"19","article-title":"Romifidina or xilazina combined with ketamine in dogs premedicated with methrotrimepromazine","volume":"3","author":"Luna SPL","year":"2000","journal-title":"Braz J Res Anim Sci."},{"issue":"3","key":"ref12","first-page":"23","article-title":"Efeitos cardiorrespirat\u00f3rios da associa\u00e7\u00e3o de tiletamina\/zolazepam em c\u00e3es (canis familiaris) pr\u00e9-tratados pela acepromazina","volume":"37","author":"Almeida EMP","year":"2000","journal-title":"Braz J Vet Res Anim Sci"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4102\/jsava.v73i3.569","article-title":"The cardiovascular and respiratory effects of medetomidine and thiopentone anaesthesia in dogs breathing at an altitude of 1486 m","volume":"73","author":"Joubert KE","year":"2002","journal-title":"J S Afr Vet Assoc."},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2460\/ajvr.1996.57.04.535","article-title":"Comparison of sedative and cardiorespiratory effects of medetomidina and medetomidina-butorfanol combination in dogs","volume":"57","author":"Ko JC","year":"1996","journal-title":"Am J Vet Res."},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1046\/j.1439-0442.2000.00302.x","article-title":"Anaesthetic and cardiopulmonary effects of balanced anaesthesia with medetomidina-midazolam and butorfanol in dogs","volume":"47","author":"Itamoto K","year":"2000","journal-title":"J Vet Med Physiol Pathol Clin Med."},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1467-2987.2004.00164.x","article-title":"Cardiopulmonary effects of medetomidina, oxymorphone, or butorphanol in elegizing-treated dogs","volume":"31","author":"Dodam JR","year":"2004","journal-title":"Vet Anaesth Analg."},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2460\/ajvr.1997.58.12.1443","article-title":"Evaluation of selected cardiopulmonary and cerebral responses during medetomidina, propofol, and halothane anesthesia for laparoscopy in dogs","volume":"58","author":"Bufalari A","year":"1997","journal-title":"Am J Vet Res."},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.2460\/ajvr.1999.60.09.1148","article-title":"Cardiorespiratory effects of a combination of medetomidine, midazolam, and butorphanol in dogs","volume":"60","author":"Pypendop B","year":"1999","journal-title":"Am J Vet Res."},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1439-0442.1997.tb01100.x","article-title":"A comparative study of medetomidine-butorphanol-ketamine and medetomidine-ketamine anaesthesia in dogs","volume":"44","author":"Tomizawa N","year":"1997","journal-title":"Zentralbl Vet A."},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.2460\/ajvr.2002.63.1671","article-title":"Effects of medetomidine-midazolam, acepromazine-butorphanol, and midazolam-butorphanol on induction dose of thiopental and propofol and on cardiopulmonary changes in dogs","volume":"63","author":"Kojima K","year":"2002","journal-title":"Am J Vet Res."},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1748-5827.2001.tb02498.x","article-title":"Effects of medetomidina and buprenorphine administered for sedation in dogs","volume":"42","author":"Robinson KJ","year":"2001","journal-title":"J Small Anim Pract."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/vr.132.14.353","article-title":"Medetomidine-butorphanol-midazolam for anaesthesia in dogs and its reversal by atipamezole","volume":"132","author":"Verstegen J","year":"1993","journal-title":"Vet Rec."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jfms.2003.11.004","article-title":"Anesthetic and physiologic effects of tiletamina, zolazepam, ketamina an xylazine combination (TKX) in feral cats undergoing surgical sterilization","volume":"6","author":"Cistola AM","year":"2004","journal-title":"J Feline Med Surg."},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.2460\/ajvr.2002.63.1022","article-title":"Effects of medetomidine-midazolam, midazolam-butorphanol, or acepromazine-butorphanol as premedicants for mask induction of anesthesia with sevoflurane in dogs","volume":"63","author":"Mutoh T","year":"2002","journal-title":"Am J Vet Res."},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1590\/S0103-84782006000500013","article-title":"Efeitos cardiorrespirat\u00f3rios do butorfanol em c\u00e3es pr\u00e9-tratados ou n\u00e3o pela levomepromazina","volume":"36","author":"Santos PSP","year":"2006","journal-title":"Cienc Rural."},{"issue":"46","key":"ref26","first-page":"223","article-title":"Monitoriza\u00e7\u00e3o da oxigena\u00e7\u00e3o e da ventila\u00e7\u00e3o","volume":"3","author":"Braz JRC","year":"1996","journal-title":"Rev Bras Anestesiol."},{"key":"ref27","first-page":"795","article-title":"Cardivascular charges in dogs given diazepam and diazepam-ketamine","volume":"47","author":"Haskins SC","year":"1986","journal-title":"Am J Vet Res."},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1590\/S0103-84782005000600017","article-title":"Efeitos cardiorrespirat\u00f3rios da buprenorfina em c\u00e3es anestesiados pelo desfluorano","volume":"35","author":"Souza AP","year":"2005","journal-title":"Cienc Rural."},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1590\/S0102-86502005000100007","article-title":"Avalia\u00e7\u00e3o algim\u00e9trica por est\u00edmulo nociceptivo t\u00e9rmico e press\u00f3rico em c\u00e3es pr\u00e9-tratados com levomepromazina, midazolam e cetamina associados ou n\u00e3o ao butorfanol ou buprenorfina","volume":"20","author":"Rosa AL","year":"2005","journal-title":"Acta Cir Bras."},{"key":"ref30","first-page":"1855","article-title":"Ketamine in dogs","volume":"46","author":"Haskins SC","year":"1985","journal-title":"Am J Vet Res."},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1590\/S0103-84782002000500008","article-title":"Eletrocardiografia de c\u00e3es anestesiados com cetamina-S ou cetamina","volume":"32","author":"Souza AP","year":"2002","journal-title":"Cienc Rural."},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1590\/S0102-09352005000300003","article-title":"Infus\u00e3o cont\u00ednua de propofol em gatos pr\u00e9-medicados com cetamina-midazolam","volume":"57","author":"Selmi AL","year":"2005","journal-title":"Arq Bras Med Vet Zootec."},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2460\/ajvr.1994.55.03.363","article-title":"Hemodynamic and analgesic effects of propofol infusion in medetomidine-premedicated dogs","volume":"55","author":"Thurmon JC","year":"1994","journal-title":"Am J Vet Res."},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.2460\/ajvr.2001.62.1073","article-title":"Comparison of medetomidina and dexmedetomidina as premedicants in dogs undergoing propofol-isoflurane anesthesia","volume":"62","author":"Kuusela E","year":"2001","journal-title":"Am J Vet Res."},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.2460\/ajvr.2005.66.1222","article-title":"Cardiopulmonary effects of fentanyl in conscious dogs and dogs sedated with a continuous rate infusion of medetomidine","volume":"66","author":"Grimm KA","year":"2005","journal-title":"Am J Vet Res."},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1532-950X.1998.tb00539.x","article-title":"Hemodynamic effects of medetomidina in the dog: a dose titration study","volume":"27","author":"Pypendop BH","year":"1998","journal-title":"Vet Surg."},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1751-0813.1996.tb09962.x","article-title":"Echocardiographic evaluation of the effects of medetomidina and xylazine in dogs","volume":"73","author":"Rand JS","year":"1996","journal-title":"Aust Vet J."},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0195-5616(99)50058-2","article-title":"a 2 agonist and antagonists","volume":"29","author":"Paddleford RR","year":"1999","journal-title":"Vet Clin North Am Small Anim Pract."},{"key":"ref39","first-page":"475","article-title":"Perioperative use of selective a-2 agonists and antagonists in small animals","volume":"45","author":"Lemke KA","year":"2004","journal-title":"Can Vet J."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1467-2987.2001.00056.x","article-title":"The cardiopulmonary effects of romifidine in with and without prior or concurrent administration of glycopyrrolate","volume":"29","author":"Sinclair MD","year":"2002","journal-title":"Vet Anaesth Analg."},{"issue":"4","key":"ref41","first-page":"241","article-title":"Evaluation of the arrhythmogenicity of a low dose of acepromazine:: comparison with xylazine","volume":"61","author":"Dyson D","year":"1997","journal-title":"Can J Vet Res."},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1590\/S0103-84782002000300011","article-title":"Levomepromazina e acepromazina no bloqueio da arritmia induzida pela adrenalina em c\u00e3es anestesiados pelo halotano","volume":"32","author":"Rezende ML","year":"2002","journal-title":"Cienc Rural."},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1590\/S0103-84782004000300024","article-title":"Avalia\u00e7\u00e3o da buprenorfina pelas vias intravenosa ou intramuscular em c\u00e3es anestesiados pelo desfluorano","volume":"34","author":"Souza AP","year":"2004","journal-title":"Cienc Rural."},{"issue":"3","key":"ref44","first-page":"518","article-title":"Avalia\u00e7\u00e3o cardiocirculat\u00f3ria do sevoflurando como agente de manuten\u00e7\u00e3o anest\u00e9sica em c\u00e3es","volume":"50","author":"Oliva VNLS","year":"2000","journal-title":"Arq Br\u00e1s M\u00e9d Vet Zootec."},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1590\/S0102-09352001000100007","article-title":"Efeitos cardiorrespirat\u00f3rios da tiletamina em c\u00e3es hipovol\u00eamicos","volume":"53","author":"Valad\u00e3o CAA","year":"2001","journal-title":"Arq Bras de Med Vet Zootec."},{"issue":"6","key":"ref46","first-page":"109","article-title":"Avalia\u00e7\u00e3o bispectral da associa\u00e7\u00f5es anest\u00e9sicas: atropina-cetamina- xilazina, levomepromazina-tiletamina\/zolazepam e levomepromazina-cetamina-midazolam em c\u00e3es","volume":"2","author":"Santos GJVG","year":"2004","journal-title":"Rev Cientif Med Vet Pequenos Anim Estim."},{"issue":"6","key":"ref47","first-page":"611","article-title":"The influence ot ketamine on the bispectral index, the spectral edge frequency 90 and the frequency bands power during propofol anestesia","volume":"48","author":"Kurehara K","year":"1999","journal-title":"Masui."},{"issue":"1","key":"ref48","first-page":"11","article-title":"EEG-bispectral index changes with ketamina versus thiamylal induction of anesthesia","volume":"39","author":"Wu CC","year":"2001","journal-title":"Acta Anaesthesiol Sin."},{"issue":"3","key":"ref49","first-page":"265","article-title":"Electroencephalographic characteristics during maintence and emergence from propofol-ketamine-fentanyl anesthesia","volume":"50","author":"Onaka M","year":"2001","journal-title":"Matsui."},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1067\/moe.2002.127587","article-title":"BIS monitoring during midazolam and midazolam-ketamine conscious intravenous sedation for oral surgery","volume":"94","author":"Morse Z","year":"2002","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","ISSN":"https:\/\/id.crossref.org\/issn\/1079-2104","issn-type":"print"},{"issue":"5","key":"ref51","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/00000542-200111000-00019","article-title":"Bispectral index monitoring during sedation with sevoflurane, midazolam and propofol","volume":"95","author":"Andra EI","year":"2001","journal-title":"Anestesiology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1097\/00000542-199206000-00022","article-title":"Synergistic interaction between a2-adrenergic agonists and benzodiazepines in rats","volume":"76","author":"Salonen M","year":"1992","journal-title":"Anesthesiology","ISSN":"https:\/\/id.crossref.org\/issn\/0003-3022","issn-type":"print"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0022-3565(24)39076-7","article-title":"Quantification of pharmacodynamic interactions between dexmedetomidina and midazolam in the rat","volume":"294","author":"Bol CJ","year":"2000","journal-title":"J Pharmacol Exp Ther."},{"key":"ref54","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1439-0442.2002.00425.x","article-title":"Quantitative Electroencephalography of medetomidine, medetomidine-midazolam and medetomidine-midazolam-butorphanol in dogs","volume":"49","author":"Itamoto K","year":"2002","journal-title":"J Vet Med."},{"key":"ref55","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1046\/j.1439-0442.2001.00381.x","article-title":"Effect of medetomidine on electroencephalography and use of a quantitative electroencephalograph for evaluating sedation levels in dogs","volume":"48","author":"Itamoto K","year":"2001","journal-title":"J Vet Med."},{"issue":"5","key":"ref56","first-page":"424","article-title":"Relationship of canine bispectral index to multiples of sevoflurane minimal alveolar concentration, usin patch or subdermal electrodes","volume":"52","author":"Grenee AS","year":"2002","journal-title":"Am Assoc Lab Anim Sci."},{"issue":"3","key":"ref57","first-page":"432","article-title":"Evaluation of the bispectral index as na indicator of degree of central nervous system depression in isoflurane anethetized horses","volume":"63","author":"Haga D","year":"2002","journal-title":"Am J Res."},{"issue":"97","key":"ref58","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00007611-200405000-00007","article-title":"Sedation during mechanical ventilation in infants and children: dexmedetomidina versus midazolam","volume":"5","author":"Tobias JD","year":"2004","journal-title":"South Med J."},{"issue":"29","key":"ref59","first-page":"44","article-title":"Indu\u00e7\u00e3o anest\u00e9sica com propofol associado ao fentanila ou a (+) cetamina ou a dexmedetomidina: avalia\u00e7\u00e3o atrav\u00e9s do BIS, da glicemia e do cortisol plam\u00e1tico","volume":"52","author":"Pereira CR","year":"2002","journal-title":"Rev Bras Anestesiol."},{"issue":"1","key":"ref60","first-page":"22","article-title":"Avalia\u00e7\u00e3o param\u00e9trica do cloridrato de dexmedetomidina em c\u00e3es pr\u00e9-tratados ou n\u00e3o pela atropina e tratados ou n\u00e3o pela quetamina","volume":"21","author":"Hatschbach E","year":"2005","journal-title":"ARS Vet."}],"container-title":["Acta Cirurgica 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