{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T02:10:25Z","timestamp":1694139025723},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>PURPOSE: To assess the initial healing after surgical stapling of the stomach using a linear cutting stapler and creating pneumoperitoneum (12-14 mmHg) for 60 minutes or 120 minutes, and compare it with the healing of a staple line not submitted to increased pressure. METHODS: A total of 30 dogs were divided into three groups of 10 animals each: Group I (control group - surgical stapling), Group II (surgical stapling and increased intra-abdominal pressure for 60 minutes) and Group III (surgical stapling and increased intra-abdominal pressure for 120 minutes). All dogs were maintained under general anesthesia for two hours after surgical stapling. Seven days after surgery, the area around the staple line was macroscopically and microscopically examined. RESULTS: The macroscopic examination of the samples (n = 30) did not show dehiscence, fistula or abscess. Adhesions between the omentum and the staple line were observed in all animals of Groups II and III (n = 20), which were significantly different from Group I (p = 0.008*). The histopathological analysis showed normal healing up to day 7 in the control animals (n = 10). When these results were compared with those of Groups II and III (n = 20), non-parametric tests revealed that there was a significant difference with regard to certain parameters of the early stages of healing, such as fibroblast migration (p = 0.011*), edema (p &lt; 0.001*) and congestion (p = 0.011*). These alterations affected reepithelization (p &lt; 0.001*), and consequently the late stages of healing. CONCLUSIONS: Each group showed different healing stages, and the healing process was delayed in the groups submitted to increased pressure, especially in the group submitted to increased pressure for longer time.<\/jats:p>","DOI":"10.1590\/s0102-86502007000500010","type":"journal-article","created":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T15:47:05Z","timestamp":1191512825000},"page":"379-386","source":"Crossref","is-referenced-by-count":2,"title":["Effects of increased intra-abdominal pressure on the healing process after surgical stapling of the stomach of dogs"],"prefix":"10.1590","volume":"22","author":[{"given":"Nilson","family":"Chaves Jr","sequence":"first","affiliation":[{"name":"University Severino Sombra,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciene de Tassis","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"University Severino Sombra,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro","family":"Colleoni","sequence":"additional","affiliation":[{"name":"UNIFESP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos","family":"Del Grande","sequence":"additional","affiliation":[{"name":"UNIFESP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00000542-197503000-00008","article-title":"Cardiovascular effects of intraperitoneal insufflation with carbon dioxide and nitrous oxide in the dog","volume":"42","author":"Ivankovich AD","year":"1975","journal-title":"Anesthesiology","ISSN":"http:\/\/id.crossref.org\/issn\/0003-3022","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0022-4804(87)90041-2","article-title":"Changes in visceral blood flow with elevated intraabdominal pressure","volume":"43","author":"Caldwell CB","year":"1987","journal-title":"J Surg Res."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00005373-199208000-00019","article-title":"Effect of increased intra-abdominal pressure on hepatic arterial, portal venous, and hepatic microcirculatory blood flow","volume":"33","author":"Diebel LN","year":"1992","journal-title":"J Trauma","ISSN":"http:\/\/id.crossref.org\/issn\/0022-5282","issn-type":"print"},{"key":"ref4","first-page":"96","article-title":"Intra-abdominal hypertension and abdominal compartment syndrome","volume":"7","author":"Cheatham ML","year":"1999","journal-title":"New Horizons","ISSN":"http:\/\/id.crossref.org\/issn\/0884-0326","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0002-9610(99)00175-0","article-title":"Effect of persistently elevated intraabdominal pressure on healing of colonic anastomoses","volume":"178","author":"Kologlu M","year":"1999","journal-title":"Am J Surg."},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1007\/s00464-001-9193-4","article-title":"The effects of increased intraabdominal pressure on colonic anastomoses","volume":"16","author":"Polat C","year":"2002","journal-title":"Surg Endosc."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0002-9610(92)90014-I","article-title":"Factors influencing wound dehiscence","volume":"163","author":"Riou JP","year":"1992","journal-title":"Am J Surg."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0039-6109(05)70566-1","article-title":"General principles of wound healing","volume":"77","author":"Witte MB","year":"1997","journal-title":"Surg Clin North Am."},{"key":"ref9","first-page":"1","article-title":"Biology of wound healing","volume":"2","author":"Nwomeh BC","year":"1997","journal-title":"J.Surg Pathol."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1001\/archsurg.1988.01400260118015","article-title":"Fibrin sealant in high-risk colonic anastomoses","volume":"123","author":"Houston KA","year":"1988","journal-title":"Arch. 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