{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T17:39:40Z","timestamp":1648921180574},"reference-count":39,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>PURPOSE: The aim of this study was to investigate whether the hind limbs or intestinal tract is the most important initiator of the inflammatory response secondary aortic clamping and hind limb ischemia\/reperfusion injury. METHODS: Blood samples of Wistar rats obtained from posterior cava vein, portal vein, and heart cavity during either laparotomy (control group, n=8) or laparotomy + 2 h of aortic clamping and bilateral hind limb ischemia (ischemia group, n=8), or 2 h after ischemia and 2 h of reperfusion (ischemia-reperfusion group, n=8) were assayed for interleukin 6 (IL-6) and C-reactive protein (CRP). RESULTS: Serum IL-6 at the heart (223.6\u00b1197.9 [10-832] pg\/mL) was higher (p&lt;0.001) than at both portal (133.08\u00b1108.52 [4-372] pg\/mL) and posterior cava veins (127.58\u00b1109.15 [8-388] pg\/mL). CRP was not significant different among groups. CONCLUSION: The splanchnic region is also a source of inflammatory response secondary to ischemia and reperfusion of the hind limbs.<\/jats:p>","DOI":"10.1590\/s0102-86502007000700008","type":"journal-article","created":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T16:20:23Z","timestamp":1192551623000},"page":"34-39","source":"Crossref","is-referenced-by-count":4,"title":["The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury"],"prefix":"10.1590","volume":"22","author":[{"given":"M\u00e1rcio Benedito Palma","family":"Pimenta","sequence":"first","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Eduardo de","family":"Aguilar-Nascimento","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dely Cristina","family":"Martins","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Ribastski da","family":"Silva","sequence":"additional","affiliation":[{"name":"Hospital Santa Rosa, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1tia Leston","family":"Bacelo","sequence":"additional","affiliation":[{"name":"Hospital Santa Rosa, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel Cristina","family":"Bocchese","sequence":"additional","affiliation":[{"name":"Hospital Santa Rosa, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarai","family":"Zaffani","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elieser","family":"Zaffani","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9rika Alessandra Oliveira","family":"Silveira","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aracelle Victor do","family":"Carmo","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Sampaio Saldanha","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1177\/003591576505811P109","article-title":"The post-mortem incidence of abdominal aortic aneurysm","volume":"58","author":"Turk KAD","year":"1965","journal-title":"Proc R Soc Med","ISSN":"http:\/\/id.crossref.org\/issn\/0035-9157","issn-type":"print"},{"key":"ref2","article-title":"Population screening for aortic aneurysms","volume":"2","author":"Allen PI","year":"1987","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0140-6736(88)90649-6","article-title":"Oxford screening programme for abdominal aortic aneurysm in men aged 65 to 74 years","volume":"2","author":"Collin J","year":"1988","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1078-5884(96)80049-9","article-title":"Screening for abdominal aortic aneurysm: a computer assisted cost-utility analysis","volume":"11","author":"St Leger AS","year":"1996","journal-title":"Eur J Vasc Endovasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1078-5884","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/S0140-6736(98)10137-X","article-title":"Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms: The UK Small Aneurysm Trial Participants","volume":"352","year":"1998","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S1078-5884(97)80105-0","article-title":"Surgical management of 671 abdominal aortic aneurysms: a 13 year review from a single centre","volume":"13","author":"Sayers RD","year":"1997","journal-title":"Eur J Vasc Endovasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1078-5884","issn-type":"print"},{"key":"ref7","first-page":"512","author":"Meesters RC","year":"1994"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis: The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine","volume":"101","author":"Bone RC","year":"1992","journal-title":"Chest","ISSN":"http:\/\/id.crossref.org\/issn\/0012-3692","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1001\/archsurg.1980.01380020006003","article-title":"Multiple system organ failure: The role of uncontrolled infection","volume":"115","author":"Fry DE","year":"1980","journal-title":"Arch Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0004-0010","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0020-1383(02)00416-3","article-title":"Current concepts of the inflammatory response after major trauma: an update","volume":"34","author":"Giannoudis PV","year":"2003","journal-title":"Injury","ISSN":"http:\/\/id.crossref.org\/issn\/0020-1383","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ejvs.2004.03.026","article-title":"Ischaemia-reperfusion injury and regional inflammatory responses in abdominal aortic aneurysm repair","volume":"28","author":"Norwood MG","year":"2004","journal-title":"Eur J Vasc Endovasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1078-5884","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/bmb\/ldh025","article-title":"Vascular ischaemia and reperfusion injury","volume":"70","author":"Eltzschig HK","year":"2004","journal-title":"Br Med Bull","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1420","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00000658-199204000-00009","article-title":"Cytokine serum level during severe sepsis in human IL-6 as a marker of severity","volume":"215","author":"Damas P","year":"1992","journal-title":"Ann Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0003-4932","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1097\/00003246-200206000-00029","article-title":"Systemic and pulmonary effector cell function after injury","volume":"30","author":"Muehlstedt SG","year":"2002","journal-title":"Crit Care Med","ISSN":"http:\/\/id.crossref.org\/issn\/0090-3493","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1097\/00005373-200106000-00004","article-title":"Major secondary surgery in blunt trauma patients and perioperative cytokine liberation: determination of the clinical relevance of biochemical markers","volume":"50","author":"Pape HC","year":"2001","journal-title":"J Trauma","ISSN":"http:\/\/id.crossref.org\/issn\/0022-5282","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/00005373-199604000-00018","article-title":"Posttraumatic inflammatory response, secondary operations, and late multiple organ failure","volume":"40","author":"Waydhas C","year":"1996","journal-title":"J Trauma","ISSN":"http:\/\/id.crossref.org\/issn\/0022-5282","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3109\/17453679809117625","article-title":"Serum CRP and IL-6 levels after trauma: Not predictive of septic complications in 31 patients","volume":"69","author":"Giannoudis PV","year":"1998","journal-title":"Acta Orthop Scand","ISSN":"http:\/\/id.crossref.org\/issn\/0001-6470","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s001340050543","article-title":"Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome","volume":"24","author":"Mimoz O","year":"1998","journal-title":"Intensive Care Med","ISSN":"http:\/\/id.crossref.org\/issn\/0342-4642","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1046\/j.0007-1323.2001.01927.x","article-title":"Pro- and anti-inflammatory cytokine release in open versus endovascular repair of abdominal aortic aneurysm","volume":"88","author":"Rowlands TE","year":"2001","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S1078-5884(96)80278-4","article-title":"Oxygen free radical and cytokine generation during endovascular and conventional aneurysm repair","volume":"12","author":"Thompson MM","year":"1996","journal-title":"Eur J Vasc Endovasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1078-5884","issn-type":"print"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1053\/ejvs.1998.0767","article-title":"Cytokine and fibrinogen response in patients undergoing open abdominal aortic aneurysm surgery","volume":"17","author":"Holmberg A","year":"1999","journal-title":"Eur J Vasc Endovasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1078-5884","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1053\/ejvs.2000.1063","article-title":"Intestinal manipulation during elective aortic aneurysm surgery leads to portal endotoxaemia and mucosal barrier dysfunction","volume":"19","author":"Lau LL","year":"2000","journal-title":"Eur J Vasc Endovasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1078-5884","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/00000658-197806000-00009","article-title":"Inferior mesenteric artery stump pressure: a reliable index for safe IMA ligation during abdominal aortic aneurysmectomy","volume":"187","author":"Ernst CB","year":"1978","journal-title":"Ann Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0003-4932","issn-type":"print"},{"key":"ref24","first-page":"557","article-title":"Colonic ischemia: the Achilles heel of ruptured aortic aneurysm repair","volume":"62","author":"Piotrowski JJ","year":"1996","journal-title":"Am Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0003-1348","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S1078-5884(97)80061-5","article-title":"Risk-factors for intestinal ischaemia after aortoiliac surgery: A combined cohort and case-control study of 2824 operations","volume":"13","author":"Bjorck M","year":"1997","journal-title":"Eur J Vasc Endovasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1078-5884","issn-type":"print"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/1043-4666(93)90034-3","article-title":"High levels of portal TNF-alpha during abdominal aortic surgery in man","volume":"5","author":"Cabie A","year":"1993","journal-title":"Cytokine","ISSN":"http:\/\/id.crossref.org\/issn\/1043-4666","issn-type":"print"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0046-8177(92)90317-V","article-title":"Neutrophils as mediators of human skeletal muscle ischemia-reperfusion syndrome","volume":"23","author":"Formigli L","year":"1992","journal-title":"Hum Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0046-8177","issn-type":"print"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0002-9610(97)89593-1","article-title":"Vitamin E protects human skeletal muscle from damage during surgical ischemia-reperfusion","volume":"173","author":"Novelli GP","year":"1997","journal-title":"Am J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9610","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/bjs.1800841023","article-title":"Lower limb ischaemia-reperfusion injury alters gastrointestinal structure and function","volume":"84","author":"Yassin MM","year":"1997","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0950-821X(05)80234-8","article-title":"Lower limb ischaemia and reperfusion alters gut permeability","volume":"6","author":"Corson RJ","year":"1992","journal-title":"Eur J Vasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0950-821X","issn-type":"print"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1046\/j.1365-2168.1998.00717.x","article-title":"Lower limb ischaemia-reperfusion injury causes endotoxaemia and endogenous antiendotoxin antibody consumption but not bacterial translocation","volume":"85","author":"Yassin MM","year":"1998","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1365-2168.2002.01973.x","article-title":"Effects of experimental lower-limb ischaemia-reperfusion injury on the mesenteric microcirculation","volume":"89","author":"Wehrens XH","year":"2002","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"},{"key":"ref33","first-page":"134","article-title":"Oxidative alterations, total antioxidant status and nitric oxide study in rats submitted to ischemia and reperfusion of hind limbs","volume":"20","author":"Francisco Neto A","year":"2005","journal-title":"Acta Cir Bras"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0002-9610(05)80967-5","article-title":"Portal endotoxin and cytokine responses to abdominal aortic surgery","volume":"166","author":"Baigrie RJ","year":"1993","journal-title":"Am J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9610","issn-type":"print"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1053\/ejvs.2001.1304","article-title":"Extraperitoneal approach reduces neutrophil activation, systemic inflammatory response and organ dysfunctionin aortic aneurysm surgery","volume":"21","author":"Lau LL","year":"2001","journal-title":"Eur J Vasc Endovasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1078-5884","issn-type":"print"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1002\/bjs.4691","article-title":"Interleukin 6 production during abdominal aortic aneurysm repair arises from the gastrointestinal tract and not the legs","volume":"91","author":"Norwood MG","year":"2004","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00024382-199905000-00001","article-title":"Pro- and anti-inflammatory cytokine-response in abdominal aortic aneurysm repair: a clinical model of ischemia-reperfusion","volume":"11","author":"Holzheimer RG","year":"1999","journal-title":"Shock","ISSN":"http:\/\/id.crossref.org\/issn\/1073-2322","issn-type":"print"},{"key":"ref38","first-page":"161","article-title":"Sequence of morphological alterations in a small intestinal ischaemia\/reperfusion model of the anesthetized rat: A light microscopy study","volume":"73","author":"Illyes G","year":"1992","journal-title":"Int J Exp Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0959-9673","issn-type":"print"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000070606","article-title":"Benefits of intraluminal injection of glutamine for intestinal mucosa during ischemia-reperfusion","volume":"35","author":"de Aguilar-Nascimento JE","year":"2003","journal-title":"Eur Surg Res","ISSN":"http:\/\/id.crossref.org\/issn\/0014-312X","issn-type":"print"}],"container-title":["Acta Cirurgica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/acb\/v22s1\/08.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T21:02:35Z","timestamp":1629925355000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502007000700008&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":39,"journal-issue":{"issue":"suppl 1","published-print":{"date-parts":[[2007]]}},"alternative-id":["S0102-86502007000700008"],"URL":"https:\/\/doi.org\/10.1590\/s0102-86502007000700008","relation":{},"ISSN":["0102-8650"],"issn-type":[{"value":"0102-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}