{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T20:03:46Z","timestamp":1749499426100},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>PURPOSE: The aim of this study was to investigate the effect of enemas containing probiotics and budesonide on the systemic inflammatory response in experimental colitis. METHODS: Fifty male Wistar rats with experimental colitis induced by 10% acetic acid enema were randomized to five groups (10 rats each) according to the treatment: group 1 - saline solution, group 2 - budesonide (0.75 mg\/kg\/day), group 3 - probiotics (1mg\/day), group 4 - probiotics plus budesonide, and group 5 - control, with not-treated rats. The following variables were studied: body weight, serum levels of albumin, C-reactive protein and interleucine-6 (IL-6). RESULTS: All animals lost weight between the beginning and the end of the experiment (280+ 16 mg versus 249+21 mg, p&lt; 0.001). There was a significant decrease in the serum albumin between the normal pre-induction level (3.45 + 0.49mg\/dL) and the 1st day after colitis induction (1.61+051mg\/dL, p&lt; 0.001) in all treated groups when compared to the control group. C- reactive protein increased after induction and diminished on the 7th day in all groups. In the control group there was an increase in the IL-6 after colitis induction. None of the treated groups significantly differed from IL-6 pre-colitis status (p&gt;0.05). Only probiotic rats presented a significant decrease of IL-6 than controls (0,30\u00b10,08 mg\/dL vs. 0,19\u00b10,03 mg\/dL; p&lt;0.01). CONCLUSION: Probiotic associated with budesonida Probiotics are effective to diminished inflammatory status mediated by IL-6 in experimental colitis.<\/jats:p>","DOI":"10.1590\/s0102-86502007000700009","type":"journal-article","created":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T16:20:23Z","timestamp":1192551623000},"page":"40-45","source":"Crossref","is-referenced-by-count":9,"title":["Effects of budesonide and probiotics enemas on the systemic inflammatory response of rats with experimental colitis"],"prefix":"10.1590","volume":"22","author":[{"given":"Mardem Machado de","family":"Souza","sequence":"first","affiliation":[{"name":"Universidade de Cuiab\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Eduardo de","family":"Aguilar-Nascimento","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Borges","family":"Dock-Nascimento","sequence":"additional","affiliation":[{"name":"UFMT, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11894-002-0024-0","article-title":"The pathogenesis of inflammatory bowel disease: translational implications for clinicians","volume":"4","author":"Abreu MT","year":"2001","journal-title":"Curr Gastroenterol Rep"},{"key":"ref2","first-page":"219","article-title":"Enemas de ciclosporina(cya) no tratamento de colite ulcerativa induzida, em ratos, por acido ac\u00e9tico","volume":"21","author":"Amaral R","year":"2001","journal-title":"Rev Bras Coloproctol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.addr.2003.11.003","article-title":"Probiotics in inflammatory bowel disease-therapeutic rationale and role","volume":"56","author":"Shanahan F","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s11894-003-0043-5","article-title":"Future therapies for inflammatory bowel disease","volume":"5","author":"Bickston SJ","year":"2003","journal-title":"Curr Gastroenterol Rep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0025-7753(01)71716-2","article-title":"Metaan\u00e1lisis sobre la efectividad de la budesonida en la enfermedad inflamatoria intestinal","volume":"116","author":"Nos P","year":"2001","journal-title":"Med Clin"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1542\/peds.109.4.678","article-title":"Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis","volume":"109","author":"Van Niel CW","year":"2002","journal-title":"Pediatrics","ISSN":"http:\/\/id.crossref.org\/issn\/0031-4005","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1023\/A:1020501202369","article-title":"Efficacy of probiotic use in acute diarrhea in children: a meta-analysis","volume":"47","author":"Huang JS","year":"2002","journal-title":"Dig Dis Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0163-2116","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00054725-200405000-00018","article-title":"Probiotics and the management of inflammatory bowel disease","volume":"10","author":"Fedorak RN","year":"2004","journal-title":"Inflamm Bowel Dis","ISSN":"http:\/\/id.crossref.org\/issn\/1078-0998","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijfoodmicro.2004.11.032","article-title":"Probiotic effects of Lactobacillus casei on DDS-induced ulcerative colitis in mice","volume":"103","author":"Herias MV","year":"2005","journal-title":"Int J Food Microbiol","ISSN":"http:\/\/id.crossref.org\/issn\/0168-1605","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/S0016-5085(99)70029-6","article-title":"Probiotics in inflammatory bowel disease: new insight to patogeesis or a possible therapeutic alternative?","volume":"116","author":"Campieri M","year":"1999","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref11","series-title":"Aspectos morfol\u00f3gicos e morfom\u00e9tricos do processo inflamat\u00f3rio na colite difusa induzida por \u00e1cido ac\u00e9tico a 10 %, em ratos e tratada com \u00e1cido 5-amino-2 hidroxibenz\u00f3ico (5-ASA) ou com extrato aquoso de Myracroduon urundeuva Fr. 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