{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:59:45Z","timestamp":1789739985530,"version":"4.0.1"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>PURPOSE: Hyperbaric oxygen therapy (HOT) consists of intermittent inhalations of 100% oxygen at a pressure higher than 1 atm. It is an important adjuvant therapy in pathological processes like soft tissue infections, radiation injury, gas gangrene, osteomyelitis and decompressive diseases. Cisplatin, a potent antineoplastic drug, widely used in cancer therapy is highly ototoxic causing bilateral, irreversible damage to the hearing of high frequency sounds (4-8 KHz). OBJECTIVE:This experimental study conducted at the Faculty of Medicine of Ribeirao Preto, University of Sao Paulo aims to evaluate Hyperbaric Oxygen Therapy as an otoprotection agent against drug toxicity. METHODS: Albino guinea pigs were divided into two groups: in Group A, 5 animals (10 cochlea) received cisplatin, i. p., 8.0 mg\/kg\/day during three days and afterwards were submitted to HOT; in Group B, 3 animals (6cochlea) received cisplatin, i. p. 8.0mg\/kg\/day during three days. Guinea pigs were evaluated by acoustic otoemissions (AOE) and scanning electron microscopy (SEM). RESULTS: Group B animals showed loss of auditory functions as measured by AOE and distorted outer hair cells by SEM. In Group A, outer hair cells shown by SEM images were mostly preserved. CONCLUSION: It is presumed that Hyperbaric Oxygen Therapy has a protector effect against cisplatin ototoxicity.<\/jats:p>","DOI":"10.1590\/s0102-86502008000700013","type":"journal-article","created":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T02:37:58Z","timestamp":1212028678000},"page":"72-76","source":"Crossref","is-referenced-by-count":8,"title":["The role of hyperbaric oxygen therapy (HOT) as an otoprotection agent against cisplatin ototoxicity"],"prefix":"10.1590","volume":"23","author":[{"given":"Camila C.","family":"Yassuda","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Elisa M.","family":"Righetti","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina L.","family":"Cury","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c2ngelo","family":"Hyppolito","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio A. de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"F\u00e9res","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","first-page":"7","article-title":"Otoprotection of auditory hair cell against amikacin ototoxicity","volume":"68","author":"Oliveira JAA","year":"2002","journal-title":"Rev Bras Otorrinolaringol"},{"key":"ref2","first-page":"467","article-title":"Ototoxicity of Cisdichlorommine Platinum (II) (NSC -119875): Hearing loss and Other Toxic Effects in Rhesus Monkeys","volume":"59","author":"Stadinicki SW","year":"1975","journal-title":"Can Chemother"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1365-2605.1987.tb00203.x","article-title":"Ototoxity of cisplatin","volume":"10","author":"Laurell G","year":"1987","journal-title":"Int J Androl","ISSN":"https:\/\/id.crossref.org\/issn\/0105-6263","issn-type":"print"},{"key":"ref4","series-title":"The Toxicity of anticancer drugs","first-page":"82","author":"Powis GD","year":"1991"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1288\/00005537-198212000-00013","article-title":"Inner ear hystophatology in patiennts treated with cisplatin","volume":"92","author":"Wright CG","year":"1982","journal-title":"Laringoscope"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000276683","article-title":"Comparative ototoxicity of cisplatin during acute and chronic treatment","volume":"56","author":"Saito T","year":"1994","journal-title":"ORL J Otorhinolaryngol Relat Spec","ISSN":"https:\/\/id.crossref.org\/issn\/0301-1569","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0378-5955(87)90104-3","article-title":"Effect of cisplatin on hair cell morphology and lateral wall Na,K-ATPase activity","volume":"26","author":"Barron SE","year":"1987","journal-title":"Hear Res","ISSN":"https:\/\/id.crossref.org\/issn\/0378-5955","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1288\/00005537-199107000-00004","article-title":"Toxic effects of ciplatin alone and in combination with gentamicin in stria vascularis of guinea pigs","volume":"101","author":"Kohn S","year":"1991","journal-title":"The Larymgoscope"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0378-5955(89)90125-1","article-title":"The Ototoxic Effect of Ciplatin in Guinea Pigs in Relation to Dosage","volume":"38","author":"Laurell G","year":"1989","journal-title":"Hearing Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0194-5998(98)70014-2","article-title":"Experimental model of cisplatin ototxicity in chinchilas","volume":"119","author":"Janning MH","year":"1998","journal-title":"Otolaryngol Head Neck Surg","ISSN":"https:\/\/id.crossref.org\/issn\/0194-5998","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0378-5955(98)00130-0","article-title":"Protective effects of a neurothophic ACTH (4-9) analog on cisplatin ototoxicity in relation to the cisplatin dose: an electrocochleogarphic study in albino guine pigs","volume":"124","author":"Stengs CH","year":"1998","journal-title":"Hear Res","ISSN":"https:\/\/id.crossref.org\/issn\/0378-5955","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-5955(00)00059-9","article-title":"Dose- depend effect of 8-day ciplatin administration upon the morphology of the albino guinea pig cochlea","volume":"144","author":"Cardinaal RM","year":"2000","journal-title":"Hear Res","ISSN":"https:\/\/id.crossref.org\/issn\/0378-5955","issn-type":"print"},{"key":"ref13","first-page":"521","article-title":"Effect of high- dose ciplatin on auditory brainstem responses and otoacoustic emissions in laboratory animals","volume":"21","author":"Sockalingam R","year":"2000","journal-title":"Am J Otol","ISSN":"https:\/\/id.crossref.org\/issn\/0192-9763","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1006\/faat.1995.1100","article-title":"Mechanism of protection by diethyldithiocarbamate against cisplatin ototxicity: Antioxidant System","volume":"26","author":"Rybak LP","year":"1995","journal-title":"Fundamental and Apllied Toxicology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1097\/00005537-199911000-00003","article-title":"Application of Antioxidants and Other Agents to Prevent Ciplatin Ototoxicity","volume":"109","author":"Rybak LP","year":"1999","journal-title":"The Laryngoscope"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-5955(98)00194-4","article-title":"Cisplatin ototoxicity and the possibly protective effect of alpha-melanocyte stimulatong hormone","volume":"128","author":"Heijmen PS","year":"1999","journal-title":"Hearing Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1097\/00005537-199908000-00014","article-title":"Fosfomycin does not inhibit the tumoricidal efficacy of cisplatinum","volume":"109","author":"Jordan JA","year":"1999","journal-title":"The Laryngoscope"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3950\/jibiinkoka.102.907","article-title":"Experimental studies of the protective effect of ginkgo biloba extract (GBE) on cisplatin- induced toxicity in rats","volume":"102","author":"Fukaya H","year":"1999","journal-title":"Nippon Jibiinkoka Gakkai Kaiho","ISSN":"https:\/\/id.crossref.org\/issn\/0030-6622","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0378-5955(00)00061-7","article-title":"Histological effects of Co-administration of an ACTH(4-9) analog, ORG 2766, on cisplatin ototocity in the albino guinea pig","volume":"144","author":"Cardinaal RM","year":"2000","journal-title":"Hear Res","ISSN":"https:\/\/id.crossref.org\/issn\/0378-5955","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1034\/j.1600-079X.2001.280202.x","article-title":"Ototocity caused by cisplatin is ameliorated by melatonin and other antioxidants","volume":"28","author":"Lopez-Gonzalez MA","year":"2000","journal-title":"J Pineal Res Copenhagen"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/00005373-199908000-00045","article-title":"Hyperbaric oxygen treatment: a brief overview of a controversial topic","volume":"47","author":"Sheridan RL","year":"1999","journal-title":"J Trauma","ISSN":"https:\/\/id.crossref.org\/issn\/0022-5282","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/00006534-199305000-00022","article-title":"Morphologic analysis of the microcirculation during reperfusion of ischemic skeletal muscle and effect of hyperbaric oxygen","volume":"91","author":"Zamboni WA","year":"1993","journal-title":"Plast Reconstr Surg","ISSN":"https:\/\/id.crossref.org\/issn\/0032-1052","issn-type":"print"},{"key":"ref23","author":"Buras J","year":"1999"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.33549\/physiolres.930284","article-title":"The effect of hyperbaric oxygen treatment on oxidative stress in experimental acute necrotizing pancreatitis","volume":"52","author":"Yasar M","year":"2003","journal-title":"Physiol Res","ISSN":"https:\/\/id.crossref.org\/issn\/0862-8408","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/000164801316878863","article-title":"The use of Preyer\u00b4s reflex in evaluation of hearing in mice","volume":"121","author":"Jero J","year":"2001","journal-title":"Acta Otolaryngol","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6489","issn-type":"print"},{"key":"ref26","series-title":"Ototoxicidade pela cisplatina: autodefesa das c\u00e9lulas ciliadas externas e otoprote\u00e7\u00e3o pelo extrato de Ginkgo biloba (EGB 761) e salicilato de s\u00f3dio","author":"Hyppolito MA","year":"2004"}],"container-title":["Acta Cirurgica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/acb\/v23s1\/13.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T20:29:32Z","timestamp":1708979372000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502008000700013&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":26,"journal-issue":{"issue":"suppl 1","published-print":{"date-parts":[[2008]]}},"alternative-id":["S0102-86502008000700013"],"URL":"https:\/\/doi.org\/10.1590\/s0102-86502008000700013","relation":{},"ISSN":["0102-8650"],"issn-type":[{"value":"0102-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}