{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T14:36:54Z","timestamp":1648823814322},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>PURPOSE: To evaluate retinal manifestations of Schistosomiasis mansoni in its hepatosplenic form in mice. METHODS: It was performed a study with two groups of mice; one of them was infected with 40 cercariae of Schistosoma mansoni. After 120 days of the infection, the eyes underwent a retinal microscopy study. The histology findings were reported. Histomorphometric analysis was also performed, including: thickness measurement of the retinal layer and the number of the ganglion layer cells. RESULTS: In one case a retinal granuloma was found. The analysis of the other histological sections demonstrated normal architecture of the retina. The mean thickness of the retinal layer between the two groups were similar (41.81\u00b16.09\u00b5m versus 38.48\u00b18.58\u00b5m - p=0.279); as well as the mean number of the ganglion layer cells (20.93\u00b14.88 versus 20.64\u00b14.10 - p=0.864). Disorganization of the retinal layers was not identified and the histomorphometric analysis revealed no significant difference between the two groups. CONCLUSION: The absence of findings in this study does not exclude that hemodynamic and autoregulation changes associated with hepatosplenic schistosomiasis could be correlated to retinal manifestations. It is necessary that other methods with a high parasite infection should be performed.<\/jats:p>","DOI":"10.1590\/s0102-86502009000600014","type":"journal-article","created":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T08:38:42Z","timestamp":1260434322000},"page":"502-506","source":"Crossref","is-referenced-by-count":3,"title":["Histological and histomorphometric evaluation of the retina of mice infected with Schistosoma mansoni in its hepatosplenic form"],"prefix":"10.1590","volume":"24","author":[{"given":"Maria Cec\u00edlia de Aguiar","family":"Rem\u00edgio","sequence":"first","affiliation":[{"name":"UFPE,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Teixeira","family":"Brandt","sequence":"additional","affiliation":[{"name":"UFPE,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicodemos Teles de","family":"Pontes Filho","sequence":"additional","affiliation":[{"name":"UFPE,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica Camelo Pessoa de Azevedo","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"UFPE,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Prevenci\u00f3n y controle de la esquistosomiasis y las geohelmintiasis: Informe de un comit\u00e9 de expertos de la OMS","volume":"912","year":"2005"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0001-706X(03)00029-9","article-title":"Quantification of clinical morbidity associated with schistosome infection in sub-saharian Africa","volume":"86","author":"Van Der Werf MJ","year":"2003","journal-title":"Acta Tropica","ISSN":"http:\/\/id.crossref.org\/issn\/0001-706X","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/bjo.69.4.294","article-title":"Schistosomotic Choroiditis I: fundoscopic changes and differential diagnosis","volume":"69","author":"Or\u00e9fice F","year":"1985","journal-title":"Br J Ophthalmol","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1161","issn-type":"print"},{"issue":"4","key":"ref4","first-page":"115","article-title":"Aspectos experimentais e cl\u00ednicos das manifesta\u00e7\u00f5es oculares da esquistossomose mansoni","volume":"22","author":"Queiroz JM","year":"1961","journal-title":"Oftalmol Iberoam"},{"key":"ref5","first-page":"123","article-title":"Altera\u00e7\u00f5es retinianas na esquistossomose hepatoespl\u00eanica","volume":"24","author":"Lemos E","year":"1980","journal-title":"Rev Bras Oftalmol","ISSN":"http:\/\/id.crossref.org\/issn\/0034-7280","issn-type":"print"},{"issue":"2","key":"ref6","first-page":"117","article-title":"Camada de fibras nervosas da retina em portadores de esquistossomose hepatoespl\u00eanica: An\u00e1lise com laser confocal polarizado","volume":"48","author":"Matos MAG","year":"2003","journal-title":"Anais da Faculdade de Medicina da Universidade Federal de Pernambuco","ISSN":"http:\/\/id.crossref.org\/issn\/0365-2416","issn-type":"print"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/0002-9394(68)94397-3","article-title":"Intraocular Schistosoma mansoni","volume":"65","author":"Newton JC","year":"1968","journal-title":"Am J Ophthalmol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9394","issn-type":"print"},{"issue":"1","key":"ref8","first-page":"45","article-title":"Hemodin\u00e2mica ocular em portadores da forma hepatoespl\u00eanica da esquistossomose mans\u00f4nica: avalia\u00e7\u00e3o dopplerfluxom\u00e9trica","volume":"50","author":"Souza ACD","year":"2005","journal-title":"Anais da Faculdade de Medicina do Centro de Ci\u00eancias da Sa\u00fade da UFPE"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/bjo.69.4.300","article-title":"Schistosomotic Choroiditis II: report of first case","volume":"69","author":"Pittella JEH","year":"1985","journal-title":"Br J Ophthalmol","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1161","issn-type":"print"},{"key":"ref10","first-page":"123","article-title":"Uve\u00edte esquistossom\u00f3tica: altera\u00e7\u00f5es fundosc\u00f3picas achados histol\u00f3gicos do ovo do S. mansoni abordagem da etiologia e tratamento","volume":"51(3)","author":"Or\u00e9fice F","year":"1988","journal-title":"Arq Bras Oftalmol","ISSN":"http:\/\/id.crossref.org\/issn\/0004-2749","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1590\/S0074-02762002000900030","article-title":"Retinal fluorescein contrast arrival time of young patients with the hepatosplenic form of the Schistosomiasis mansoni","volume":"97","author":"Souza ACD","year":"2002","journal-title":"Mem Inst Oswaldo Cruz","ISSN":"http:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"issue":"9","key":"ref12","first-page":"1043","article-title":"Bulbar subconjunctival tumor secondary to periocular schistosome granuloma","volume":"27","author":"Randriamora JT","year":"2004","journal-title":"J Fr Ophtalmol","ISSN":"http:\/\/id.crossref.org\/issn\/0181-5512","issn-type":"print"},{"key":"ref13","first-page":"675","article-title":"La bilharziose palpebro-conjuntivale","volume":"165","author":"Bey MS","year":"1928","journal-title":"Ann Ocul"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0014-4894(58)90013-4","article-title":"Implantation of Schistosoma douthitti into the eyes of rats","volume":"7","author":"Goodchild CG","year":"1958","journal-title":"Exp Parasitol","ISSN":"http:\/\/id.crossref.org\/issn\/0014-4894","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/bjo.55.2.106","article-title":"Experimental ocular schistosomiasis","volume":"55","author":"Abboud IA","year":"1971","journal-title":"Br J Ophthalmol","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1161","issn-type":"print"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"970","DOI":"10.2307\/3279255","article-title":"Eye penetration by cercariae of Schistosoma mansoni","volume":"61","author":"Lester RJG","year":"1975","journal-title":"J Parasitol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3395","issn-type":"print"},{"key":"ref17","first-page":"478","article-title":"Intraocular granuloma: a Schistosoma mansoni model of ocular inflammation","volume":"23","author":"Stein PC","year":"1982","journal-title":"Invest Ophthalmol Vis Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0146-0404","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000310722","article-title":"Glaucoma capillaries and pericytes: blood flow regulation","volume":"210","author":"Anderson DR","year":"1996","journal-title":"Ophthalmologica","ISSN":"http:\/\/id.crossref.org\/issn\/0030-3755","issn-type":"print"},{"key":"ref19","first-page":"231","article-title":"Pathophysiology of portal hypertension","volume":"59(Suppl 2)","author":"Cichoz-lach H","year":"2008","journal-title":"J Physiol Pharmacol","ISSN":"http:\/\/id.crossref.org\/issn\/0867-5910","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"S259","DOI":"10.1097\/MCG.0b013e318150d0e1","article-title":"Molecular mechanisms of increased intrahepatic resistance in portal hypertension","volume":"41","author":"Shah V","year":"2007","journal-title":"J Clin Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0192-0790","issn-type":"print"},{"issue":"5","key":"ref21","first-page":"285","article-title":"N\u00edveis de \u00f3xido n\u00edtrico produzidos por mon\u00f3citos em portadores de esquistossomose hepatoespl\u00eanica que se submeteram a esplenectomia, ligadura da veia g\u00e1strica esquerda e auto-implante de tecido espl\u00eanico no omento maior","volume":"21","author":"Brandt CT","year":"2006","journal-title":"Acta Cir Bras"},{"key":"ref22","first-page":"20","article-title":"O camundongo (Mus musculus) como modelo experimental na esquistossomose mansoni","volume":"3","author":"Rocha MOC","year":"1994","journal-title":"Rev Med Minas Gerais"}],"container-title":["Acta Cirurgica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/acb\/v24n6\/14.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T12:34:31Z","timestamp":1495802071000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502009000600014&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0102-86502009000600014"],"URL":"https:\/\/doi.org\/10.1590\/s0102-86502009000600014","relation":{},"ISSN":["0102-8650"],"issn-type":[{"value":"0102-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}