{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T13:13:42Z","timestamp":1759497222664},"reference-count":35,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>PURPOSE: Determine the effects of the MSG (monosodium glutamate) in the offspring of pregnant rats through the comparison of the weight, NAL (nasal-anal length) and IL (Index of Lee) at birth and with 21 days of life. METHODS: Pregnant Wistar rats and their offspring were divided into 3 groups: GC, G10 and G20. Each of the groups received 0%, 10% and 20% of MSG, respectively from coupling until the end of the weaning period. RESULTS: Neither weight nor NAL were different among the groups at birth. The group G20 at birth had an IL lower than the group GC (p&lt;0,05) and with 21 days of life presented weight and NAL lower than the groups G10 and this lower than the GC (p&lt;0,01). Otherwise the G20 at 21 days of life had the IL similar to the other two groups. The weight profit percentage from birth to the 21st day of life was lower in the G20 regarding the other two groups (p&lt;0,01). The G20 had a NAL increase percentage from birth to the 21st day of life lower than the G10 and this lower than the GC (p&lt;0,01). CONCLUSIONS: MSG presented a dose-dependent relation in the variables weight and NAL. It caused a decrease in the growth pattern as well as in the weight gain pattern until the 21st day of life. The IL of the group 20% had an increased in relation to the control group after 3 weeks of follow up.<\/jats:p>","DOI":"10.1590\/s0102-86502010000100010","type":"journal-article","created":{"date-parts":[[2010,1,28]],"date-time":"2010-01-28T04:47:09Z","timestamp":1264654029000},"page":"37-42","source":"Crossref","is-referenced-by-count":9,"title":["Effect of the oral administration of monosodium glutamate during pregnancy and breast-feeding in the offspring of pregnant Wistar rats"],"prefix":"10.1590","volume":"25","author":[{"given":"Vinicius","family":"von Diemen","sequence":"first","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Roberto Maciel","family":"Trindade","sequence":"additional","affiliation":[{"name":"UFRGS; Clinics Hospital, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1097\/01.grf.0000135386.19065.f2","article-title":"Surgical management of obesity","volume":"47","author":"Nagle AP","year":"2004","journal-title":"Clin Obstet Gynecol."},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0002-9610(02)00914-5","article-title":"Obesity and its surgical management","volume":"184","author":"Livingston EH.","year":"2002","journal-title":"Am J Surg."},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1467-789X.2005.00165.x","article-title":"Prevalence of obesity in the United States","volume":"6","author":"Baskin ML","year":"2005","journal-title":"Obes Rev."},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1467-789X.2005.00187.x","article-title":"Prevalence of obesity in Australia","volume":"6","author":"Thorburn AW","year":"2005","journal-title":"Obes Rev."},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1467-789X.2005.00164.x","article-title":"Prevalence of obesity in Great Britain","volume":"6","author":"Rennie KL","year":"2005","journal-title":"Obes Rev."},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1467-789X.2006.00292.x","article-title":"The burden of overweight and obesity in the Asia-Pacific region","volume":"8","year":"2007","journal-title":"Obes Rev."},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/sj.ejcn.1602263","article-title":"Obesity, voracity, and short stature: the impact of glutamate on the regulation of appetite","volume":"60","author":"Hermanussen M","year":"2006","journal-title":"Eur J Clin Nutr."},{"issue":"9","key":"ref8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/chemse\/bjh246","article-title":"Behavioral comparisons of the tastes of L-alanine and monosodium glutamate in rats","volume":"29","author":"Taylor-Burds CC","year":"2004","journal-title":"Chem Senses."},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.nut.2004.10.013","article-title":"Monosodium glutamate in standard and high-fiber diets: metabolic syndrome and oxidative stress in rats","volume":"21","author":"Diniz YS","year":"2005","journal-title":"Nutrition","ISSN":"http:\/\/id.crossref.org\/issn\/0029-6600","issn-type":"print"},{"issue":"2","key":"ref10","first-page":"341","article-title":"Effect of monosodium glutamate given orally on appetite control (a new theory for the obesity epidemic)","volume":"122","author":"Tresguerres Fernandez","year":"2005","journal-title":"An R Acad Nac Med (Madr)","ISSN":"http:\/\/id.crossref.org\/issn\/0034-0634","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1053S","DOI":"10.1093\/jn\/130.4.1053S","article-title":"Pituitary hormone secretion in normal male humans: acute responses to a large, oral dose of monosodium glutamate","volume":"130","author":"Fernstrom JD","year":"2000","journal-title":"J Nutr."},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/sj.ijo.0801517","article-title":"Decreased lipolysis and enhanced glycerol and glucose utilization by adipose tissue prior to development of obesity in monosodium glutamate (MSG) treated-rats","volume":"25","author":"Dolnikoff M","year":"2001","journal-title":"Int J Obes Relat Metab Disord."},{"issue":"1","key":"ref13","first-page":"63","article-title":"Glucose tolerance and insulin action in monosodium glutamate (MSG) obese exercise-trained rats","volume":"33","author":"de Mello MA","year":"2001","journal-title":"Physiol Chem Phys Med NMR."},{"issue":"1","key":"ref14","first-page":"43","article-title":"Insulin secretion in monosodium glutamate (MSG) obese rats submitted to aerobic exercise training","volume":"35","author":"de Souza CT","year":"2003","journal-title":"Physiol Chem Phys Med NMR."},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0091-3057(79)90324-1","article-title":"Juvenile-onset obesity and deficits in caloric regulation in MSG-treated rats","volume":"10","author":"Kanarek RB","year":"1979","journal-title":"Pharmacol Biochem Behav."},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3748\/wjg.v11.i2.242","article-title":"Screening of stimulatory effects of dietary risk factors on mouse intestinal cell kinetics","volume":"11","author":"Shivshankar P","year":"2005","journal-title":"World J Gastroenterol."},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1079\/BJN19760005","article-title":"The induction of obesity in rodents by means of monosodium glutamate","volume":"35","author":"Bunyan J","year":"1976","journal-title":"Br J Nutr."},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1467-789x.2001.00029.x","article-title":"Obesity prevalence and trends in Latin-American countries","volume":"2","author":"Filozof C","year":"2001","journal-title":"Obes Rev."},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1467-789X.2006.00243.x","article-title":"Prevalence of obesity in Portugal","volume":"7","author":"Carmo Id","year":"2006","journal-title":"Obes Rev."},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1467-789X.2005.00174.x","article-title":"Prevalence of obesity in Iran","volume":"6","author":"Rashidi A","year":"2005","journal-title":"Obes Rev."},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/sj.ejcn.1602526","article-title":"Consensus meeting: monosodium glutamate - an update","volume":"61","author":"Beyreuther K","year":"2007","journal-title":"Eur J Clin Nutr."},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0002-9378(75)90616-X","article-title":"Placental transfer of glutamate and its metabolites in the primate","volume":"122","author":"Stegink LD","year":"1975","journal-title":"Am J Obstet Gynecol."},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/00207458408985353","article-title":"Prenatal monosodium glutamate (MSG) treatment given through the mother's diet causes behavioral deficits in rat offspring","volume":"23","author":"Frieder B","year":"1984","journal-title":"Int J Neurosci."},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.gassur.2004.02.003","article-title":"A surgical rat model of human Roux-en-Y gastric bypass","volume":"8","author":"Meguid MM","year":"2004","journal-title":"J Gastrointest Surg."},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1538\/expanim.49.239","article-title":"Effects of chronic administration of sibutramine on body weight, food intake and motor activity in neonatally monosodium glutamate-treated obese female rats: relationship of antiobesity effect with monoamines","volume":"49","author":"Nakagawa T","year":"2000","journal-title":"Exp Anim."},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.2337\/diab.46.12.2035","article-title":"Leptin gene expression increases with age independent of increasing adiposity in rats","volume":"46","author":"Li H","year":"1997","journal-title":"Diabetes","ISSN":"http:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1590\/S0102-86502001000100006","article-title":"Efeito da vagotomia troncular em ratos injetados na fase neonatal com glutamato monoss\u00f3dico: estudo biom\u00e9trico","volume":"16","author":"Souza F","year":"2001","journal-title":"Acta Cir Bras."},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0006-8993(96)01181-X","article-title":"Effects of maternal oral administration of monosodium glutamate at a late stage of pregnancy on developing mouse fetal brain","volume":"747","author":"Yu T","year":"1997","journal-title":"Brain Res."},{"issue":"1-3","key":"ref29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.regpep.2004.10.006","article-title":"Leptin-like effects of MTII are augmented in MSG-obese rats","volume":"127","author":"Kim YW","year":"2005","journal-title":"Regul Pept."},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000072799","article-title":"Adrenal enucleation in MSG-damaged hyperleptinemic male rats transiently restores adrenal sensitivity to leptin","volume":"78","author":"Perello M","year":"2003","journal-title":"Neuroendocrinology","ISSN":"http:\/\/id.crossref.org\/issn\/0028-3835","issn-type":"print"},{"issue":"880","key":"ref31","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1126\/science.164.3880.719","article-title":"Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate","volume":"164","author":"Olney JW","year":"1969","journal-title":"Science."},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000123079","article-title":"Monosodium glutamate disruption of behavioral and endocrine function in the female rat","volume":"31","author":"Rodriguez-Sierra JF","year":"1980","journal-title":"Neuroendocrinology","ISSN":"http:\/\/id.crossref.org\/issn\/0028-3835","issn-type":"print"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000122829","article-title":"Late endocrine effects of administering monosodium glutamate to neonatal rats","volume":"26","author":"Bakke JL","year":"1978","journal-title":"Neuroendocrinology","ISSN":"http:\/\/id.crossref.org\/issn\/0028-3835","issn-type":"print"},{"issue":"4288","key":"ref34","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1126\/science.557837","article-title":"Monosodium glutamate admlinistration to the newborn reduces reproductive ability in female and male mice","volume":"196","author":"Pizzi WJ","year":"1977","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"1","key":"ref35","first-page":"133","article-title":"Effect of perinatal monosodium glutamate treatment on endocrine functions of rats in maturity","volume":"28","author":"Lengvari I.","year":"1977","journal-title":"Acta Biol Acad Sci Hung."}],"container-title":["Acta Cirurgica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/acb\/v25n1\/10.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T07:56:32Z","timestamp":1558770992000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502010000100010&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0102-86502010000100010"],"URL":"https:\/\/doi.org\/10.1590\/s0102-86502010000100010","relation":{},"ISSN":["0102-8650"],"issn-type":[{"value":"0102-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}