{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:50:28Z","timestamp":1760953828748},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>PURPOSE: It has been reported that the oral squamous cell carcinoma (OSCC) in tongue shows a more infiltrative profile, aggressive clinical course and poor prognosis, which may be related to a higher metastatic potencial. The aim of the present study was to assess the expression of \u03b2-catenin in OSCC of the tongue and its correlation with tumor metastasis. METHODS: Twenty four cases were selected and divided in two groups: metastatic group (n=12) and non-metastatic group (n=12). A semi-quantitative analysis of the \u03b2-catenin expression was performed in the invasive tumor front and cases were graded as follows: negative (score 0), positive (score +), and strongly positive (score ++). RESULTS: It was detected that 33%, 50% and 17% of the cases in metastatic group were scored 0, + and ++, respectively, and the non-metastatic group showed that 42% were scored \"0\", 33% scored + and 25% scored ++. Statistical analysis showed no diference between the studied groups. CONCLUSIONS: Based on these results, it can be concluded that the immunoexpression of \u03b2-catenin does not represent a valuable tool to predict metastatic potencial of OSCC in tongue.<\/jats:p>","DOI":"10.1590\/s0102-86502010000600010","type":"journal-article","created":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T21:15:51Z","timestamp":1290806151000},"page":"513-517","source":"Crossref","is-referenced-by-count":10,"title":["Correlation of \u03b2-catenin expresssion and metastasis in tongue squamous cell carcinoma"],"prefix":"10.1590","volume":"25","author":[{"given":"Roseana de Almeida","family":"Freitas","sequence":"first","affiliation":[{"name":"UFRN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ericka Janine Dantas","family":"Silveira","sequence":"additional","affiliation":[{"name":"UFRN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo Borges da","family":"Silveira","sequence":"additional","affiliation":[{"name":"University of Brasilia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabyanne Mazutti da","family":"Silva","sequence":"additional","affiliation":[{"name":"University of Brasilia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivad\u00e1vio Fernandes Batista de","family":"Amorim","sequence":"additional","affiliation":[{"name":"UnB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1601-0825.2006.01295.x","article-title":"Altered E-cadherin\/\u03b2-catenin expression in oral squamous carcinoma with and without nodal metastasis","volume":"13","author":"Mahomed F","year":"2007","journal-title":"Oral 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in oral squamous cell carcinoma","volume":"35","author":"Ueda G","year":"2006","journal-title":"Int J Oral Maxillofac Surg."},{"issue":"19","key":"ref14","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1097\/00029330-200810010-00003","article-title":"\u03b2-catenin expression pattern in primary oral squamous cell carcinoma","volume":"121","author":"Cai Z","year":"2008","journal-title":"Chin Med J."},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/path.1204","article-title":"Gains and losses of adhesion molecules (CD-44, E-cadherin and \u03b2-catenin) during oral carcinogenesis and tumour progression","volume":"98","author":"B\u00e1nkfalvi A","year":"2002","journal-title":"J Pathol."}],"container-title":["Acta Cirurgica 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