{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:23:42Z","timestamp":1761488622969,"version":"3.38.0"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>Purpose: To investigate the prevalence of anal squamous intraepithelial lesions (ASIL) or anal cancer in patients attended at the Tropical Medicine Foundation of Amazonas. Methods: 344 patients consecutively attended at the institution, in 2007\/2008, were distributed in the following strata according to presence\/abscense of at risk conditions for anal cancer: Group 1 _ HIV-positive men-who-have-sex-with-men (101); Group 2 _ HIV-positive females (49); Group 3 _ patients without any at risk condition for anal cancer (53); Group 4 _ HIV-positive heterosexual men (38); Group 5 _ HIV-negative patients, without anoreceptive sexual habits, but with other at risk conditions for anal cancer (45); Group 6 _ HIV-negative men-who-have-sex-with-men (26); and Group 7 _ HIV-negative anoreceptive females (32). The histopathological results of biopsies guided by high-resolution anoscopy were analyzed by frequentist and bayesian statistics in order to calculate the point-prevalence of ASIL\/cancer and observe any eventual preponderance of one group over the other. Results: The point-prevalence of ASIL for all the patients studied was 93\/344 (27%), the difference between HIV-positive and negative patients being statistically significant (38.3% versus 13.5%; p &lt; 0.0001). The prevalence of ASIL for each one of the groups studied was: Group 1 = 49.5%, Group 2 = 28.6%, Group 3 = 3.8%, Group 4 = 21.1%, Group 5 = 11.1%, Group 6 = 30.8% and Group 7 = 18.8%. Standard residual analysis demonstrated that ASIL was significantly prevalent in patients of Group 1 and high-grade ASIL in patients of Group 2. The odds for ASIL of Group 1 was significantly higher in comparison to Groups 2, 3, 4, 5 and 7 (p &lt; 0.03). The odds for ASIL of Groups 2, 4 and 6 were significantly higher in comparison to Group 3 (p &lt; 0.03). Conclusions: In the patients studied, ASIL (low and\/or high-grade) tended to be significantly more prevalent in HIV-positive patients. Nonetheless, HIV-negative anoreceptive patients also presented great probability to have anal cancer precursor lesions, mainly those of the male gender.<\/jats:p>","DOI":"10.1590\/s0102-86502011000100012","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T13:26:00Z","timestamp":1296134760000},"page":"64-71","source":"Crossref","is-referenced-by-count":5,"title":["Anal cancer precursor lesions in HIV-positive and HIV-negative patients seen at a tertiary health institution in Brazil"],"prefix":"10.1590","volume":"26","author":[{"given":"Ivan Tramujas da Costa e","family":"Silva","sequence":"first","affiliation":[{"name":"UEA; Federal University of Amazonas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 de Ribamar","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Tropical Medicine Foundation of Amazonas; UEA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosilene Viana 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Carlos de Lima","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Tropical Medicine Foundation of Amazonas; UFAM, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM198710153171601","article-title":"Sexual practices, sexually transmitted diseases, and the incidence of anal cancer","volume":"317","author":"Daling JR","year":"1987","journal-title":"N Engl J Med."},{"key":"ref2","first-page":"1","article-title":"Anogenital human papillomavirus infection and associated neoplasia in HIV-positive men and women","volume":"13","author":"Bratcher J","year":"2008","journal-title":"The PRN Notebook"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0140-6736(91)91233-K","article-title":"Aetiological parallel between anal cancer and cervical 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