{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:44:09Z","timestamp":1762955049097},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>PURPOSE: Comparing the ionizing radiation effects on bone neoformation of rats tibiae previously submitted to radiotherapy with a single dosage of 30Gy with the contralateral tibiae that have received secondary radiation. METHODS: In thirty male Wistar rats, 30 days before surgical procedure when round defects would be created on the bone, the right tibia was irradiated with 30Gy and the left tibia received a calculated secondary radiation dose of 7Gy. Sacrifices were performed after 4, 7, 14, 21, 56 and 84 postoperative days and both tibiae were removed for histological processing. RESULTS: The left tibiae that received the dose of 7Gy has shown more bone neoformation from 14th postoperative days, giving evidences of less damage to cellular population responsible by bone neoformation. On the other hand, the dose of 30Gyon right tibiae did not exhibit significant differences among the periods, suggesting damage of long-lasting or even permanent duration. CONCLUSION: Tibiae submitted to radiation dose of 30Gy have shown more damage to bone cells than tibiae that received secondary radiation dose of 7Gy, especially observed on 14th, 56th and 84th postoperative days.<\/jats:p>","DOI":"10.1590\/s0102-86502011000600012","type":"journal-article","created":{"date-parts":[[2011,10,29]],"date-time":"2011-10-29T04:01:16Z","timestamp":1319860876000},"page":"475-480","source":"Crossref","is-referenced-by-count":8,"title":["Effects of ionizing radiation on bone neoformation: histometric study in Wistar rats tibiae"],"prefix":"10.1590","volume":"26","author":[{"given":"Susette Cavicchioli","family":"Lucatto","sequence":"first","affiliation":[{"name":"UNIFESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo","family":"Guilherme","sequence":"additional","affiliation":[{"name":"UNIFESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano Lauria","family":"Dib","sequence":"additional","affiliation":[{"name":"Paulista University, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena Regina Comodo","family":"Segreto","sequence":"additional","affiliation":[{"name":"UNIFESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Tereza de Seixas","family":"Alves","sequence":"additional","affiliation":[{"name":"UNIFESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emne Hammoud","family":"Gumieiro","sequence":"additional","affiliation":[{"name":"UNIFESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Schmitutz","family":"Jahn","sequence":"additional","affiliation":[{"name":"UNIFESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronaldo Antonio","family":"Leite","sequence":"additional","affiliation":[{"name":"UNIFESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0167-8140(95)01583-3","article-title":"Radionecrosis of the mandibula: a retrospective analysis of the incidence and risk factors","volume":"36","author":"Glanzmann C","year":"1995","journal-title":"Radiother Oncol","ISSN":"http:\/\/id.crossref.org\/issn\/0167-8140","issn-type":"print"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0278-2391(97)90478-X","article-title":"Osteoradionecrosis of the jaws: a retrospective study of the background factors and treatment in 104 cases","volume":"55","author":"Curi MM","year":"1997","journal-title":"J Oral Maxillofac Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0278-2391","issn-type":"print"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0167-8140(02)00191-3","article-title":"Analysis of mandibular dose distribution in radiotherapy for oropharyngeal cancer: dosimetric and clinical results in 18 patients","volume":"66","author":"Jereczek-Fossa BA","year":"2003","journal-title":"Radiother Oncol","ISSN":"http:\/\/id.crossref.org\/issn\/0167-8140","issn-type":"print"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijom.2004.06.013","article-title":"Implications of radiation dosimetry of the mandible in patients with carcinomas of the oral cavity and nasopharynx treated with intensity modulated radiation therapy","volume":"34","author":"Parliament M","year":"2005","journal-title":"Int J Oral Maxillofac Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0901-5027","issn-type":"print"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3109\/02844318509074508","article-title":"Alterations in bone regenerative capacity after low level gamma irradiation: a quantitative study","volume":"19","author":"Jacobsson M","year":"1985","journal-title":"Scand J Plast Reconstr Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0036-5556","issn-type":"print"},{"key":"ref6","first-page":"1","article-title":"Bone tissue response to irradiation and treatment model of mandibular irradiation injury: an experimental and clinical study","volume":"428","author":"Aitasalo K","year":"1986","journal-title":"Acta Otolaryngol Suppl"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1177\/00220345690480054901","article-title":"Bone remodeling dynamics following local x-irradiation","volume":"48","author":"Bures MF","year":"1969","journal-title":"II. 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