{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T17:54:04Z","timestamp":1649181244220},"reference-count":12,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>PURPOSE: To study the influence of albumin on changes of liver function in the extrahepatic biliary obstruction through an experimental model in rats. METHODS: Sixty rats were divided into four groups: Group C (Control): 6 animals. Group M (Fictitious Operation): 18 rats underwent laparotomy and handling of the bile ducts; Groups O (extrahepatic biliary obstruction) and A (Treated with 2% albumin): 18 animals in each group underwent ligation of the ductus liver; The animals in groups M, O and A were divided into three subgroups of 6 animals each to be killed in the 7, 14 and 21 days postoperative (POD). Blood was drawn for determination of total bilirubin (TB), indirect bilirubin (IB), direct bilirubin (DB), alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT). RESULTS: On POD 7, BI levels were 4.5 mg \/ dl in group O and 2.1 mg \/ dl in group A (p = 0.025). On the 14th POD, the levels of PA were 1185.2 U \/ l in the group and O 458.3 U \/ l in group A (p = 0.004). ALT levels were 101.7 U \/ l in the group O and 75.7 U \/ l in group A (= 0.037). On POD 21, the levels of ALP were 1069.5 U \/ l in the group O and 468.3 U \/ l in group A (p = 0, 004). CONCLUSION: The administration of albumin reduced the serum levels of bilirubin in the 7th day of supplementation<\/jats:p>","DOI":"10.1590\/s0102-86502011000800013","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T01:19:31Z","timestamp":1319591971000},"page":"70-73","source":"Crossref","is-referenced-by-count":2,"title":["Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstruction"],"prefix":"10.1590","volume":"26","author":[{"given":"Jorge Fernando Rebou\u00e7as","family":"Lessa","sequence":"first","affiliation":[{"name":"UnB,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Siqueira","family":"Rangel","sequence":"additional","affiliation":[{"name":"UnB,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilton Jos\u00e9 de Almeida","family":"Costa Junior","sequence":"additional","affiliation":[{"name":"UnB,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando Castro e","family":"Silva","sequence":"additional","affiliation":[{"name":"University of Sao Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Augusto Teixeira da","family":"Cruz","sequence":"additional","affiliation":[{"name":"UnB,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Batista de","family":"Sousa","sequence":"additional","affiliation":[{"name":"UnB,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/014860710703100294","article-title":"Administration of glutamine after hemorrhagic shock restores cellular energy, reduces cell apoptosis and damage, and increases survival","volume":"31","author":"Yang R","year":"2007","journal-title":"Parenter Enteral Nutr."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/cc5717","article-title":"Glutamine induces heat-shock protein and protects against Escherichia coli lipopolysaccharide-induced vascular hyporeactivity in rats","volume":"11","author":"Jing L","year":"2007","journal-title":"Crit Care."},{"key":"ref3","first-page":"421","article-title":"Liver damage induced by acute cholestasis in the rat is ameliorated partially by L-arginine","volume":"120","author":"Muriel P","year":"1998","journal-title":"Comp Biochem Physiol C."},{"key":"ref4","first-page":"159","article-title":"Altera\u00e7\u00f5es hep\u00e1ticas e n\u00edveis s\u00e9ricos de aminotransferases 24 horas ap\u00f3s ligadura do ducto hep\u00e1tico em ratos","volume":"6","author":"Castro e Silva O","year":"1991","journal-title":"Acta Cir Bras."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/bja\/85.4.599","article-title":"The role of albumin in critical illness","volume":"85","author":"Nicholson JP","year":"2000","journal-title":"Review article. 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