{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T16:20:54Z","timestamp":1648657254123},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>PURPOSE: To evaluate the effects of abdominal sepsis on adhesion formation and colon anastomosis healing in rats. METHODS: Forty rats were distributed in two groups containing 20 rats each for left colon anastomosis in the presence (Group S) or absence (Group N) of induced sepsis by cecal ligation and puncture. Each group was divided into subgroups for euthanasia on the third (N3 and S3) or seventh (N7 or S7) post-operative day. The amount of adhesions was evaluated and a segment of the colon was removed for histopathologic analysis, bursting strength assessment, hydroxyproline and the determination of tissue collagen. RESULTS: The subjects which underwent cecal ligation and puncture presented a higher amount of intra-abdominal adherences in both third (p=0,00) and seventh (p=0,00) post-operatory days. Smaller bursting strengths were found in the S3 subgroup, and greater bursting strengths were found in the S7 subgroup. There was no difference in the variations on the concentrations of hydroxyproline, tissue collagen and histopathology. CONCLUSIONS: The peritoneal infection which was developed by cecal ligation and puncture raised the amount of intra-cavitary adhesions. There was a decrease in the amount of colonic anastomosis on the third post-operatory day with a following raise on the seventh without any effects on other healing parameters.<\/jats:p>","DOI":"10.1590\/s0102-86502011000800018","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T05:19:24Z","timestamp":1319606364000},"page":"100-105","source":"Crossref","is-referenced-by-count":6,"title":["Study on adhesion formation and the healing of colon anastomosis in rats with induced peritoneal sepsis"],"prefix":"10.1590","volume":"26","author":[{"given":"Silvana Marques e","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Vin\u00edcius Melo de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"UnB,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Malta","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"UnB,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Pirani","family":"Carneiro","sequence":"additional","affiliation":[{"name":"UnB,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e2nia Maria Moraes","family":"Ferreira","sequence":"additional","affiliation":[{"name":"UnB,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio Serafim","family":"Parra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Feres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Batista de","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00384-007-0399-3","article-title":"Incidence, consequences and risk factors for anastomotic dehiscence after colorectal surgery: a prospective monocentric study","volume":"23","author":"Buchs NC","year":"2008","journal-title":"Int J Colorectal Dis."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0002-9610(99)80082-8","article-title":"Intra-abdominal sepsis impairs colonic reparative collagen synthesis","volume":"171","author":"Ahrendt GM","year":"1996","journal-title":"Am J Surg."},{"key":"ref3","first-page":"79","article-title":"Evolu\u00e7\u00e3o de anastomosis do c\u00f3lon esquerdo ap\u00f3s a indu\u00e7\u00e3o de peritonite focal, em ratos","volume":"33","author":"Biondo-Sim\u00f5es MLP","year":"1996","journal-title":"Arq Gastroenterol."},{"key":"ref4","first-page":"48","article-title":"Efeito da peritonite fecal na cicatriza\u00e7\u00e3o do c\u00f3lon distal no rato. Avalia\u00e7\u00e3o anatomopatol\u00f3gica, estudo da for\u00e7a de ruptura e da hidroxiprolina tecidual","volume":"8","author":"Naresse LE","year":"1993","journal-title":"Acta Cir Bras."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1159\/000050149","article-title":"Peritoneal adhesions: ethiology, pathophysiology and clinical significance. Recent advances in prevention and management","volume":"18","author":"Liakakos T","year":"2001","journal-title":"Dig Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0253-4886","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.surg.2006.09.010","article-title":"Enteric bacteria and their antigens may stimulate postoperative peritoneal adhesion formation","volume":"141","author":"Cahill RA","year":"2007","journal-title":"Surgery."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch D","year":"2009","journal-title":"Nature Protocols."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archsurg.1974.01350300081019","article-title":"Role of proteolytic enzyme in the prevention of postoperative intraperitoneal adhesion","volume":"108","author":"Nair SK","year":"1974","journal-title":"Arch Surg."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000100068","article-title":"Effect of melatonin on healing of colonic anastomosis in a rat model of peritonitis","volume":"39","author":"Ozen IO","year":"2007","journal-title":"Eur Surg Res."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s00268-005-0511-1","article-title":"Effect of temporary abdominal closure on colonic anastomosis and postoperative adhesions in experimental secondary peritonitis","volume":"30","author":"Aydin C","year":"2006","journal-title":"World J Surg."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0002-9610(02)01418-6","article-title":"Prevention of intraperitoneal adhesion formation using beta-glucan after ileocolic anastomosis in a rat bacterial peritonitis model","volume":"185","author":"Bedirli A","year":"2003","journal-title":"Am J Surg."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2168.2001.01613.x","article-title":"The intestinal flora influences adhesion formation around surgical anastomosis","volume":"88","author":"Bothin C","year":"2001","journal-title":"Br J Surg."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1590\/S0102-86502010000400013","article-title":"Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis","volume":"25","author":"Rocha AA","year":"2010","journal-title":"Acta Cir Bras."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/bjs.4146","article-title":"Colonic anastomotic strength and matrix metalloproteinase activity in an experimental model of bacterial peritonitis","volume":"90","author":"De Hingh IH","year":"2003","journal-title":"Br J Surg."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1007\/s00268-008-9696-4","article-title":"Role of activated protein C on wound healing process in left colonic anastomosis in the presence of intra-abdominal sepsis induced by cecal ligation and puncture: an experimental study in the rat","volume":"32","author":"Teke Z","year":"2008","journal-title":"World J Surg."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.amjsurg.2009.01.023","article-title":"Hydroxyethyl starch 130\/0.4 augments healing of colonic anastomosis in a rat model of peritonitis","volume":"199","author":"Wang P","year":"2010","journal-title":"Am J Surg."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1590\/S0102-86501997000200004","article-title":"Evaluation of the cicatrization of left colon anastomosis in the presence of peritonitis. An experimental study on rats","volume":"12","author":"Biondo-Sim\u00f5es MLP","year":"1997","journal-title":"Acta Cir Bras."},{"key":"ref18","first-page":"69","article-title":"Influence of peritonitis on the synthesis of collagen of the distal colon: experimental study in rats","volume":"15","author":"Biondo-Sim\u00f5es M LP","year":"2000","journal-title":"Acta Cir Bras."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1046\/j.1440-1622.2000.01890.x","article-title":"Effects of CO2 insufflation and laparotomy on wound healing in mice","volume":"70","author":"Agalar F","year":"2000","journal-title":"Aust N Z J Surg."},{"key":"ref20","first-page":"693","article-title":"The role of infection on wound healing","volume":"138","author":"De Hann BB","year":"1974","journal-title":"Surg Gynecol Obst."}],"container-title":["Acta Cirurgica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/acb\/v26s2\/a18v26s2.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T01:11:10Z","timestamp":1495847470000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502011000800018&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":20,"journal-issue":{"issue":"suppl 2","published-print":{"date-parts":[[2011]]}},"alternative-id":["S0102-86502011000800018"],"URL":"https:\/\/doi.org\/10.1590\/s0102-86502011000800018","relation":{},"ISSN":["0102-8650"],"issn-type":[{"value":"0102-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}