{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T09:28:55Z","timestamp":1661506135937},"reference-count":7,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>PURPOSE: To develop an experimental model of infravesical urinary obstruction in female rats. METHODS: After median caudal laparotomy, the urethra of 14 female rats was delicately separated from the vagina and loosely wrapped with cellophane tape measuring 0.4 x 1.0 cm. The animals were evaluated 4 (n=7) and 8 (n=7) weeks later. Five additional control animals were only subjected to separation of the urethra and vagina and monitored for 12 weeks. RESULTS: After four weeks, three rats presented vesical dilation associated with discrete ureteral ectasis in 2 animals, with the third presenting discrete hydronephrosis in one kidney. After eight weeks, five rats (71.4%) presented vesical distension with bilateral ureterohydronephrosis. No significant changes (p&gt;0.05) in serum urea or creatinine occurred in any group compared to preoperative values. CONCLUSION: We present here an inexpensive and simple method for the slow induction of urethral obstruction in adult female rats, with the development of progressive vesical hypertrophy and ureterohydronephrosis, which may be used as an experimental model for the study of different aspects of obstructive nephropathy.<\/jats:p>","DOI":"10.1590\/s0102-86502011000800020","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T01:19:32Z","timestamp":1319591972000},"page":"111-114","source":"Crossref","is-referenced-by-count":3,"title":["Chronic partial urethral obstruction in female rats: description of an experimental model and initial results"],"prefix":"10.1590","volume":"26","author":[{"given":"Silvio","family":"Tucci Jr","sequence":"first","affiliation":[{"name":"USP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Augusto Ferreira","family":"Molina","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Ferreira","family":"Cassini","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murilo Ferreira de","family":"Andrade","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilson Jos\u00e9 de","family":"Lima","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Carlos Pereira","family":"Martins","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0022-5347(01)64573-7","article-title":"In vivo cystometric evaluation of progressive bladder outlet obstruction in rats","volume":"158","author":"O'Connor Jr LT","year":"1997","journal-title":"J Urol."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00192-010-1219-9","article-title":"Intravesical oxybutynin protects the vesical wall against functional and smooth muscle changes in rabbits with detrusor overactivity","volume":"21","author":"Polido Jr A","year":"2010","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.jvir.2010.07.026","article-title":"Evaluation of formation of granulation tissue caused by metallic stent placement in a rat urethral model","volume":"21","author":"Li YD","year":"2010","journal-title":"J Vasc Interv Radiol."},{"key":"ref4","first-page":"67","article-title":"Cellophane perinephritic hypertension in the dog: some biochemical, hemodynamic and pathological characteristics","volume":"18","author":"Castro-Tavares J","year":"1981","journal-title":"Blood Vessels."},{"key":"ref5","first-page":"95","article-title":"A characterized model of left ventricular hypertrophy in the rabbit","volume":"5","author":"McIntosh MA","year":"1994","journal-title":"Cardioscience."},{"key":"ref6","first-page":"571","article-title":"Experimental studies in pelviureteric obstruction and hydronephrosis","volume":"13","author":"Groeneveld AE","year":"1984","journal-title":"Ann Acad Mad Singapore."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1464-410X.1994.tb16540.x","article-title":"Chronic hydronephrosis: renographic drainage patterns and renal morphology in an animal model","volume":"74","author":"Bowen J","year":"1994","journal-title":"Br J Urol."}],"container-title":["Acta Cirurgica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/acb\/v26s2\/a20v26s2.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T21:09:39Z","timestamp":1495832979000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502011000800020&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":7,"journal-issue":{"issue":"suppl 2","published-print":{"date-parts":[[2011]]}},"alternative-id":["S0102-86502011000800020"],"URL":"https:\/\/doi.org\/10.1590\/s0102-86502011000800020","relation":{},"ISSN":["0102-8650"],"issn-type":[{"value":"0102-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}