{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:05:18Z","timestamp":1759514718013},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>PURPOSE: To investigate the facial symmetry of high and low dose methotrexate (MTX) treated rats submitted to experimentally displaced mandibular condyle fracture through the recording of cephalometric measurements. METHODS: One hundred male Wistar rats underwent surgery using an experimental model of right condylar fracture. Animals were divided into four groups: A - saline solution (1mL\/week); B - dexamethasone (DEX) (0,15mg\/Kg); C - MTX low dose (3 mg\/Kg\/week); D - MTX high dose (30 mg\/Kg). Animals were sacrificed at 1, 7, 15, 30 and 90 days postoperatively (n=5). Body weight was recorded. Specimens were submitted to axial radiographic incidence, and cephalometric mensurations were made using a computer system. Linear measurements of skull and mandible, as well as angular measurements of mandibular deviation were taken. Data were subjected to statistical analyses among the groups, periods of sacrifice and between the sides in each group (\u03b1=0.05). RESULTS: Animals regained body weight over time, except in group D. There was reduction in the mandibular length and also changes in the maxilla as well as progressive deviation in the mandible in relation to the skull basis in group D. CONCLUSION: Treatment with high dose methotrexate had deleterious effect on facial symmetry of rats submitted to experimentally displaced condylar process fracture.<\/jats:p>","DOI":"10.1590\/s0102-86502012000300002","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T09:38:12Z","timestamp":1332927492000},"page":"210-216","source":"Crossref","is-referenced-by-count":4,"title":["Facial symmetry evaluation after experimentally displaced condylar process fracture in methotrexate treated rats"],"prefix":"10.1590","volume":"27","author":[{"given":"Samantha Cristine Santos Xisto Braga","family":"Cavalcanti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"USP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Gualberto de Cerqueira","family":"Luz","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/0278-2391(92)90484-H","article-title":"Different patterns of condylar fractures: an analysis of 382 patients in a 3-year period","volume":"50","author":"Silvennoinen U","year":"1992","journal-title":"J Oral Maxillofac Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0278-2391","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0901-5027(05)80505-3","article-title":"Therapy of condylar neck fractures","volume":"27","author":"Joss U","year":"1998","journal-title":"Int J Oral Maxillofac Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0901-5027","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1054\/ijom.2001.0147","article-title":"Rotated subcondylar process fracture in the growing animal: an experimental study in rats","volume":"30","author":"Luz JG","year":"2001","journal-title":"Int J Oral Maxillofac Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0901-5027","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1034\/j.1600-9657.2001.00088.x","article-title":"Histological evaluation of changes in the temporomandibular joint after direct and indirect trauma: an experimental study","volume":"18","author":"Y\u00fccel E","year":"2002","journal-title":"Dent Traumatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jcms.2006.01.006","article-title":"Skeletal changes after experimentally displaced condylar process fracture in growing rats","volume":"34","author":"Teixeira VCB","year":"2006","journal-title":"J Craniomaxillofac Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1010-5182","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S1010-5182(98)80063-2","article-title":"Healing of the displaced condylar process fracture: an experimental study","volume":"26","author":"Teixeira AC","year":"1998","journal-title":"J Cranio Maxillofac Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0901-5027(99)80056-3","article-title":"Long term results of nonsurgical management of condylar fractures in children","volume":"28","author":"Hovinga J","year":"1999","journal-title":"Int J Oral Maxillofac Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0901-5027","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0901-5027(99)80200-8","article-title":"Conservative treatment of unilateral condylar fractures in children: a long-term clinical and radiologic follow-up of 55 patients","volume":"28","author":"Strobl H","year":"1999","journal-title":"Int J Oral Maxillofac Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0901-5027","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1590\/S0102-86502011000200003","article-title":"Effects of the condylar process fracture on facial symmetry in rats submitted to protein undernutrition","volume":"26","author":"Rodrigues L","year":"2011","journal-title":"Acta Cir Bras"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S1010-5182(98)80062-0","article-title":"Fractures of the facial skeleton in children: a survey of patients under the age of 11 years","volume":"26","author":"Oji C","year":"1998","journal-title":"J Cranio Maxillofac Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1080\/030097402320817040","article-title":"Light and electron microscopic analysis of liver biopsy samples from rheumatoid arthritis patients receiving long-term methotrexate therapy","volume":"31","author":"Ros S","year":"2002","journal-title":"Scand. 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