{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T14:40:28Z","timestamp":1687358428677},"reference-count":54,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>PURPOSE: To study the effect of alcoholism on intestinal healing and postoperative complications in rats METHODS: One hundred and sixty rats were divided into two groups: control and treated. The control group received water and the treated group 30% ethanol. After 180 days, colotomy with anastomosis were performed. After, the groups were divided into four subgroups: 20 rats for study at the following moments: 4th, 7th, 14th and 21st postoperative. The analyzed parameters were: weight gain, breaking strength, tissue hydroxyproline, postoperative complications and histopathological study RESULTS: Weight gain was greater in the control group (p&lt;0.05). When all the subgroups were clustered, breaking strength was significantly greater in the control (p&lt;0.05). Histopathology and hydroxyproline dosage did not show differences. There were five surgical site infections in the treated group while the control group showed two (p&gt;0.05). Nine fistulas occurred in the treated group whereas the control group two (p&lt;0.05). There were three deaths in the control group and seven in the treated group (p&gt;0.05). CONCLUSIONS: Treated group undergo a malnutrition process that is revealed by lower weight gain. Impaired intestinal healing as indicated by smaller breaking strength. There were a larger number of postoperative complications in the treated animals.<\/jats:p>","DOI":"10.1590\/s0102-86502012000300006","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T09:38:08Z","timestamp":1332927488000},"page":"236-243","source":"Crossref","is-referenced-by-count":5,"title":["Intestinal healing in rats submitted to ethanol ingestion"],"prefix":"10.1590","volume":"27","author":[{"given":"Rodrigo Severo de Camargo","family":"Pereira","sequence":"first","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Nishida","family":"Hasimoto","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Pelafsky","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Llanos","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Cristina","family":"Cataneo","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar Tadeu","family":"Spadella","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Guilherme","family":"Minossi","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1590\/S1516-44462004000500003","article-title":"Custo social do consumo de \u00e1lcool","volume":"26S 1","author":"Meloni JN","year":"2004","journal-title":"Rev Psiquiatr"},{"key":"ref2","series-title":"Levantamento domiciliar sobre o uso de drogas no Brasil - 2001","first-page":"480","author":"Carlini EA","year":"2002"},{"key":"ref3","first-page":"636","article-title":"Health behavior among students of public and private schools in the metropolitan area of Sao Paulo, Brazil","volume":"34","author":"Carlini-Cotrim B","year":"2000","journal-title":"Rev Sa\u00fade P\u00fablica"},{"key":"ref4","series-title":"Levantamento sobre o consumo de drogas psicotr\u00f3picas entre estudantes do ensino m\u00e9dio e fundamental da rede p\u00fablica de ensino nas 27 capitais brasileiras-2004","author":"Galduroz JC"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"650","DOI":"10.15288\/jsa.2003.64.650","article-title":"Drunkenness among young people: across national comparisson","volume":"64","author":"Schmid H","year":"2003","journal-title":"J Stud Alcohol","ISSN":"http:\/\/id.crossref.org\/issn\/0096-882X","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/09595230412331289509","article-title":"Fourteen- to 17-year-olds' experience of risky drinking - a cross-sectional survey undertaken in south-east England","volume":"23","author":"Coleman L","year":"2004","journal-title":"Drug Alcohol Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1176\/appi.ajp.157.5.745","article-title":"Age at first alcohol use: a risk factor for the development of alcohol disorders","volume":"157","author":"DeWit DJ","year":"2000","journal-title":"Am J Psychiatry","ISSN":"http:\/\/id.crossref.org\/issn\/0002-953X","issn-type":"print"},{"key":"ref8","first-page":"63","article-title":"Epidemiology and consequences of drinking and driving","volume":"27","author":"Hingson R","year":"2003","journal-title":"Alcohol Res Health"},{"issue":"S","key":"ref9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1590\/S0104-11692010000700005","article-title":"Uso de \u00e1lcool em v\u00edtimas de acidentes de tr\u00e2nsito: estudo do n\u00edvel de alcoolemia","volume":"18","author":"Abreu AMM","year":"2010","journal-title":"Rev Latino-Am Enfermagem"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1590\/S1808-86942010000500006","article-title":"Six years of facial trauma care: an epidemiological analysis of 355 cases","volume":"76","author":"Carvalho TBO","year":"2010","journal-title":"Braz J Otorhinolaryngol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.15288\/jsa.2004.65.37","article-title":"Correlates of rape while intoxicated in a national sample of college women","volume":"65","author":"Mohler-Kuo M","year":"2004","journal-title":"J Stud Alcohol","ISSN":"http:\/\/id.crossref.org\/issn\/0096-882X","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000050729","article-title":"Relation between average alcohol consumption and disease. 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2","key":"ref16","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1111\/j.1440-1746.2007.05080.x","article-title":"Functional and morphological alterations in small intestine mucosa of chronic alcoholics","volume":"23","author":"Bronchal S","year":"2008","journal-title":"J Gastroenterol Hepatol","ISSN":"http:\/\/id.crossref.org\/issn\/0815-9319","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/(SICI)1096-9926(199611)54:5<245::AID-TERA5>3.0.CO;2-Z","article-title":"Ethanol in vitro induces epithelial cell damage and altered kinetics in the developing rat intestine","volume":"54","author":"Estrada G","year":"1996","journal-title":"Teratology","ISSN":"http:\/\/id.crossref.org\/issn\/0040-3709","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/alcalc\/37.3.229","article-title":"Effect of chronic alcohol consumption in the ethanol and acetaldehyde metabolizing systems in the rat 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associated with the occurrence of leaks in stapled rectal anastomoses: a review of 1014 patients","volume":"77","author":"Vignali A","year":"1997","journal-title":"J Am Coll Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1072-7515","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1590\/S0102-86502005000100004","article-title":"Effects of Sodium Hyaluronate and Carboxymethylcellulose membrane on collagen and fibroblast formation in bowel suture healing: experimental study in rats","volume":"20","author":"Perez AC","year":"2005","journal-title":"Acta Cir Bras"},{"key":"ref23","series-title":"Introduction to statistical analysis","author":"Dixon WJ","year":"1969","edition":"3"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0955-2863(91)90021-V","article-title":"Determination of hydroxyproline in tissue","volume":"2","author":"Switzer BR","year":"1991","journal-title":"J Nutr Biochem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/micr.20197","article-title":"Clinical review: healing in gastrointestinal anastomoses","volume":"26","author":"Thompson SK","year":"2006","journal-title":"Microsurgery","ISSN":"http:\/\/id.crossref.org\/issn\/0738-1085","issn-type":"print"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00384-002-0392-9","article-title":"Anastomotic healing in the rat colon: comparison between a radiological method, breaking strength and bursting pressure","volume":"17","author":"Mansson P","year":"2002","journal-title":"Int J Colorectal Dis","ISSN":"http:\/\/id.crossref.org\/issn\/0179-1958","issn-type":"print"},{"key":"ref27","first-page":"47","article-title":"Preoperative irradiation and colonic healing","volume":"160","author":"Weiber S","year":"1994","journal-title":"Eur J 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alcohol on nutritional status","volume":"46","author":"Lieber CS","year":"1998","journal-title":"Nutr Rev","ISSN":"http:\/\/id.crossref.org\/issn\/0029-6643","issn-type":"print"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1046\/j.1365-2168.1999.01165.x","article-title":"Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery","volume":"86","author":"Sorensen L","year":"1999","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/02841860510029707","article-title":"Lifestyle and 30-day complications to surgery for colorectal cancer","volume":"44","author":"Nickelsen TN","year":"2005","journal-title":"Acta Oncol","ISSN":"http:\/\/id.crossref.org\/issn\/0284-186X","issn-type":"print"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1302\/0301-620X.89B12.19671","article-title":"Inhibition of fracture healing","volume":"89","author":"Gaston MS","year":"2007","journal-title":"J Bone Joint Surg Br","ISSN":"http:\/\/id.crossref.org\/issn\/0301-620X","issn-type":"print"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/01.id.0000140462.33075.34","article-title":"Effects of alcohol consumption on osseointegration of titanium implants in rabbits","volume":"13","author":"Koo S","year":"2004","journal-title":"Implant Dent","ISSN":"http:\/\/id.crossref.org\/issn\/1056-6163","issn-type":"print"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/oxfordjournals.alcalc.a008407","article-title":"Alcohol abuse and healing complications after cervical hip fractures","volume":"33","author":"Nyquist F","year":"1998","journal-title":"Alcohol Alcohol","ISSN":"http:\/\/id.crossref.org\/issn\/0703-2951","issn-type":"print"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1152\/ajpheart.00080.2005","article-title":"Acute ethanol exposure impairs angiogenesis and proliferative phase of wound healing","volume":"289","author":"Radek KA","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1006\/bbrc.2000.2634","article-title":"Suppression of endothelin-converting enzyme-1during buccal mucosal ulcer healing: effect of chronic alcohol ingestion","volume":"271","author":"Slomiany BL","year":"2000","journal-title":"Biochem Biophys Res Commun","ISSN":"http:\/\/id.crossref.org\/issn\/0006-291X","issn-type":"print"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1530-0277.2006.00307.x","article-title":"Effects of acute ethanol exposure on the early inflammatory response after excisional injury","volume":"31","author":"Fitzgerald DJ","year":"2007","journal-title":"Alcohol Clin Exp Res","ISSN":"http:\/\/id.crossref.org\/issn\/0145-6008","issn-type":"print"},{"key":"ref44","first-page":"2583","article-title":"IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis","volume":"40","author":"Brito BE","year":"1999","journal-title":"Invest Ophthalmol Vis Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0146-0404","issn-type":"print"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.4049\/jimmunol.159.5.2452","article-title":"Absence of IL-1 signaling and reduced inflammatory response in IL-1 type 1 receptor-deficient mice","volume":"159","author":"Labow M","year":"1997","journal-title":"J 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subsets in alcoholics","volume":"103","author":"Cook RT","year":"1996","journal-title":"Clin Exp Immunol","ISSN":"http:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1530-0277.2006.00084.x","article-title":"Cytokines and alcohol","volume":"30","author":"Crews FT","year":"2006","journal-title":"Alcohol Clin Exp Res","ISSN":"http:\/\/id.crossref.org\/issn\/0145-6008","issn-type":"print"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1530-0277.1995.tb01545.x","article-title":"Alcohol modulation of human normal T-cell activation, maturation and migration","volume":"19","author":"Chiappelli F","year":"1995","journal-title":"Alcohol Clin Exp Res","ISSN":"http:\/\/id.crossref.org\/issn\/0145-6008","issn-type":"print"},{"key":"ref51","first-page":"131","article-title":"Alcohol immunomodulation and disease","volume":"29","author":"Watson RR","year":"1994","journal-title":"Alcohol Alcohol."},{"key":"ref52","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/cc2911","article-title":"Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock","volume":"8","author":"Von Dossow V","year":"2004","journal-title":"Crit Care","ISSN":"http:\/\/id.crossref.org\/issn\/0270-7462","issn-type":"print"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00134-001-1199-9","article-title":"Suppression of interleukin-6 to interleukin-10 ratio in chronic alcoholics: association with postoperative infections","volume":"28","author":"Sander M","year":"2002","journal-title":"Intensive Care Med","ISSN":"http:\/\/id.crossref.org\/issn\/0342-4642","issn-type":"print"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1136\/bmj.318.7194.1311","article-title":"Effect of preoperative abstinence on poor postoperative outcome in alcohol 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