{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:29:27Z","timestamp":1765279767783},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>PURPOSE: To evaluate the effect of N-acetylcysteine, as a renoprotective agent, when administered early after anesthesia induction, against ischemia\/reperfusion injury in rats anesthetized with isoflurane. METHODS: Eighteen male Wistar rats weighing &gt; 300g were anesthetized with isoflurane. The internal jugular vein and the left carotid artery were dissected and cannulated. The animals were randomly divided into GAcetyl, receiving intravenous N-acetylcysteine, 300mg\/kg, and GIsot, isotonic saline. After 30 minutes, right nephrectomy was performed and the left renal artery was clamped during 45 minutes. The animals were sacrificed after 48 hours and blood samples were taken after anesthetic induction and upon sacrificing of the animals to evaluate blood creatinine. The kidneys were sent for histological analysis. RESULTS: The variation in serum creatinine was 2.33mg\/dL \u00b1 2.21 in GAcetyl and 4.38mg\/dL \u00b1 2.13 in GIsot (p=0.074). Two animals presented intense tubular necrosis in GAcetyl, compared to 5 in GIsot. Only GAcetyl presented animals free of tubular necrosis (two) and tubular degeneration (one). CONCLUSION: After renal ischemia\/reperfusion, the rats which were given N-acetylcysteine presented less variation in serum creatinine and milder kidney injuries than the control group.<\/jats:p>","DOI":"10.1590\/s0102-86502012000400010","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T06:44:58Z","timestamp":1335336298000},"page":"340-345","source":"Crossref","is-referenced-by-count":9,"title":["Prevention of renal ischemia\/reperfusion injury in rats using acetylcysteine after anesthesia with isoflurane"],"prefix":"10.1590","volume":"27","author":[{"given":"Andr\u00e9 Marques","family":"Mansano","sequence":"first","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Thadeu Galv\u00e3o","family":"Vianna","sequence":"additional","affiliation":[{"name":"UNESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viciany 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Invest","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0002-9343(00)00612-4","article-title":"Reactive oxygen species and acute renal failure","volume":"109","author":"Nath KA","year":"2000","journal-title":"Am J Med","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9343","issn-type":"print"},{"key":"ref3","series-title":"The kidney","first-page":"211","volume-title":"Metabolic basis of ion transport","author":"Brenner BM","year":"1996","edition":"5"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1172\/JCI111524","article-title":"Oxygen free radicals in ischemic acute renal failure in the rat","volume":"74","author":"Paller MS","year":"1984","journal-title":"J Clin Invest","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","DOI":"10.1097\/00001503-200302000-00007","article-title":"Renal dysfunction after vascular surgery","volume":"16","author":"Swaminathan M","year":"2003","journal-title":"Curr Opin Anaesthesiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.bpa.2004.05.009","article-title":"Renal protection strategies in the perioperative period","volume":"18","author":"Jarnberg PO","year":"2004","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1053\/ajkd.2000.17659","article-title":"Atrial natriuretic factor in oliguric acute renal failure: Anaritide acute renal failure study group","volume":"36","author":"Lewis J","year":"2000","journal-title":"Am J Kidney Dis","ISSN":"http:\/\/id.crossref.org\/issn\/0272-6386","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1159\/000189472","article-title":"Nifedipine can preserve renal function in patients undergoing aortic surgery with infrarenal crossclamping","volume":"74","author":"Antonucci F","year":"1996","journal-title":"Nephron","ISSN":"http:\/\/id.crossref.org\/issn\/0028-2766","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1097\/00003246-200108000-00005","article-title":"Use of dopamine in acute renal failure: a meta-analysis","volume":"29","author":"Kellum JA","year":"2001","journal-title":"Crit Care Med","ISSN":"http:\/\/id.crossref.org\/issn\/0090-3493","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1681\/ASN.V11197","article-title":"Lack of renoprotective effects of dopamine and furosemide during cardiac surgery","volume":"11","author":"Lassnigg A","year":"2000","journal-title":"J Am Soc Nephrol","ISSN":"http:\/\/id.crossref.org\/issn\/1046-6673","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1055\/s-2007-1013112","article-title":"Mannitol and cardiac surgery","volume":"47","author":"Poullis M","year":"1999","journal-title":"Thorac Cardiovasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0171-6425","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s000180300001","article-title":"Molecular mechanisms of N-acetylcysteine actions","volume":"60","author":"Zafarullah M","year":"2003","journal-title":"Cell Mol Life Sci","ISSN":"http:\/\/id.crossref.org\/issn\/1420-682X","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0891-5849(89)90066-X","article-title":"The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid","volume":"6","author":"Aruoma OI","year":"1989","journal-title":"Free Radic Biol Med","ISSN":"http:\/\/id.crossref.org\/issn\/0891-5849","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S0140-6736(03)14189-X","article-title":"Acetylcysteine for prevention of contrast nephropathy: meta-analysis","volume":"362","author":"Birck R","year":"2003","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1440-1681.2006.04323.x","article-title":"Effects of N-acetyl-L-cysteine on renal haemodynamics and function in early ischaemia-reperfusion injury in rats","volume":"33","author":"Nitescu N","year":"2006","journal-title":"Clin Exp Pharmacol Physiol","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1870","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1093\/ndt\/gfk032","article-title":"N-acetylcysteine attenuates kidney injury in rats subjected to renal 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N-acetyl-cysteine on renal injury triggered by ischemia and reperfusion","volume":"38","author":"Di Giorno C","year":"2006","journal-title":"Transplant Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1345","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/ALN.0b013e318164cff8","article-title":"Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats","volume":"108","author":"Hirose R","year":"2008","journal-title":"Anesthesiology","ISSN":"http:\/\/id.crossref.org\/issn\/0003-3022","issn-type":"print"},{"key":"ref21","first-page":"F87","article-title":"Body temperature: an important determinant of severity of ischemic renal injury","volume":"251","author":"Zager RA","year":"1986","journal-title":"Am J Physiol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9513","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000542-200207000-00002","article-title":"Editorial view: anesthetic preconditioning: serendipity and science","volume":"97","author":"Warltier DC","year":"2002","journal-title":"Anesthesiology","ISSN":"http:\/\/id.crossref.org\/issn\/0003-3022","issn-type":"print"},{"key":"ref23","first-page":"F380","article-title":"Protective effects of renal ischemic preconditioning and adenosine pretreatment: role of A(1) and A(3) receptors","author":"Lee HT","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry 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