{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T14:59:49Z","timestamp":1648652389322},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>PURPOSE: Evaluation of colonic healing in spontaneously hypertensive rats. METHODS: Fifty male, young and inbred rats were used. Twenty-five Wistar Kyoto rats (WKY) as control and twenty-five spontaneously hypertensive rats (SHR) as an experimental group. Colotomy and bowel suture at 2.5 cm from the peritoneal reflection were performed. All animals were allocated randomly into sub-groups for review at the third, seventh and fourteenth days after surgery. We evaluated the concentration of angiotensin II, the burst pressure, epithelialization, the organization of the tunics of the bowel wall, inflammatory response and collagen deposition. RESULTS: The burst pressure, epithelialization, organization of the tunics and collagen deposition was not significant between groups. The inflammatory reaction was more intense in the control group on the third postoperative day (p=0.023) as the experimental group on the remaining time. CONCLUSION: Systemic arterial hypertension in rats did not influence significantly the healing process of colonic anastomoses.<\/jats:p>","DOI":"10.1590\/s0102-86502012000800001","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T23:26:51Z","timestamp":1343518011000},"page":"515-521","source":"Crossref","is-referenced-by-count":0,"title":["Influence of arterial hypertension on colonic healing in rats"],"prefix":"10.1590","volume":"27","author":[{"given":"Gilberto Luiz","family":"Ortolan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de Lourdes Pessole","family":"Biondo-Sim\u00f5es","sequence":"additional","affiliation":[{"name":"PUCPR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovani Marino","family":"F\u00e1vero","sequence":"additional","affiliation":[{"name":"UEPG,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Fernandes","sequence":"additional","affiliation":[{"name":"UEPG,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio Rodrigues","family":"Montem\u00f3r Netto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Renato","family":"Olchanheski Jr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0039-6109(05)70568-5","article-title":"Healing in the gastrointestinal tract","volume":"77","author":"Thornton FJ; Barbul A","year":"1997","journal-title":"Surg Clin North Am."},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0002-9440(10)63422-0","article-title":"Effects of angiotensin II receptor signaling during skin wound healing","volume":"165","author":"Takeda H","year":"2004","journal-title":"Am J Pathol."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/01.RES.88.1.22","article-title":"Angiotensin AT1 and AT2 receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation","volume":"88","author":"Fujiyama S","year":"2001","journal-title":"Circ Res."},{"key":"ref4"},{"issue":"5","key":"ref5","first-page":"424","article-title":"Preval\u00eancia, reconhecimento e controle da hipertens\u00e3o arterial sist\u00eamica no Estado do Rio Grande do Sul","volume":"83","author":"Gus I","year":"2004","journal-title":"Arq Bras Cardiol."},{"issue":"21","key":"ref6","first-page":"456","article-title":"State-specific trends in self-reported blood pressure screening and high blood pressure - United States, 1991-1999","volume":"51","year":"2002","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"ref7","year":"1996"},{"key":"ref8","year":"1996"},{"issue":"68","key":"ref9","first-page":"1","article-title":"A relev\u00e2ncia do c\u00e2ncer colorretal. 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