{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T12:08:59Z","timestamp":1774094939575,"version":"3.50.1"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>PURPOSE: To evaluate the antitumor activity of alcoholic extracts of green tea (Camella sinensis). METHODS: Four groups of six Wistar rats were inoculated intramuscularly with 10(6) Walker tumor cells\/mL. During 10 days, the animals received by gavage either 0.9% saline solution (Group I; negative control), solution containing 20 mg\/Kg of tamoxifen (Group II; positive control), solution containing 0.07 g\/Kg alcoholic extract of C. sinensis (Group III), or solution containing 0.14 g\/Kg alcoholic extract of C. sinensis (Group IV). Following euthanasia on the tenth day, the tumor, liver, kidneys and spleen were excised and weighed, and tumor volume and tumor growth inhibition were quantified. RESULTS: The average weight of the animals was greater in Group IV than in Group II (p=0.0107). Tumor weight was smaller in Group IV than in Group I (p=0.0062), but did not differ from Group II. Tumor volume was smaller in Groups II and IV than in Group I (p=0.0131). Tumor growth inhibition was observed in Groups II (44.67% \u00b1 32.47), III (16.83% \u00b1 53.02) and IV (66.4% \u00b1 25.82) (p&gt;0.05). The groups did not differ with regard to the weight of the excised organs. CONCLUSION: Alcoholic extracts of green tea have antitumor activity.<\/jats:p>","DOI":"10.1590\/s0102-86502012000900008","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T07:29:42Z","timestamp":1346225382000},"page":"634-638","source":"Crossref","is-referenced-by-count":7,"title":["Growth inhibition of Walker carcinosarcoma 256 with alcoholic extract of green tea leaves (Camellia sinensis)"],"prefix":"10.1590","volume":"27","author":[{"given":"Mauricl\u00e9cio Franco","family":"Ponte","sequence":"first","affiliation":[{"name":"UNIFOR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Sousa e Silva","family":"Targino","sequence":"additional","affiliation":[{"name":"UNIFOR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Alves de Lima","family":"Mota","sequence":"additional","affiliation":[{"name":"UNIFOR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Saul Peixoto","family":"Landim","sequence":"additional","affiliation":[{"name":"UNIFOR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thyciana Rodrigues","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Federal University of Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Pereira","family":"Soares","sequence":"additional","affiliation":[{"name":"UNIFOR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Roberto Pinho","family":"Pereira","sequence":"additional","affiliation":[{"name":"UNIFOR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f4nia Leite da","family":"Silva","sequence":"additional","affiliation":[{"name":"UNIFOR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Fernandes Ribeiro da","family":"Silva","sequence":"additional","affiliation":[{"name":"UNIFOR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"4","key":"ref1","first-page":"292","article-title":"Ch\u00e1 verde (Camellia sinensis) e suas propriedades funcionais nas doen\u00e7as cr\u00f4nicas n\u00e3o transmiss\u00edveis","volume":"20","author":"Senger AE","year":"2010","journal-title":"Sci Med","ISSN":"https:\/\/id.crossref.org\/issn\/0048-9727","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4178\/epih\/e2010001","article-title":"Green tea consumption and stomach cancer risk: a meta-analysis","volume":"32","author":"Kang H","year":"2010","journal-title":"Epidemiol Health"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.lfs.2007.06.011","article-title":"Tea polyphenols for health promotion","volume":"81","author":"Khan N","year":"2007","journal-title":"Life Sci","ISSN":"https:\/\/id.crossref.org\/issn\/0024-3205","issn-type":"print"},{"issue":"2","key":"ref4","first-page":"16","article-title":"O ch\u00e1 verde induz o emagrecimento e auxilia no tratamento da obesidade e sua comorbidades","volume":"1","author":"Freitas HCP","year":"2007","journal-title":"Rev Bras Obes Nut Emagrec"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/07315724.2006.10719518","article-title":"Beneficial effects of Green tea-a review","volume":"25","author":"Cabrera C","year":"2006","journal-title":"J Am Cool Nutr"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.fct.2008.02.023","article-title":"Evaluation of toxicity of green tea catechins with 90-day dietary administration to F344 rats","volume":"46","author":"Takami S","year":"2008","journal-title":"Food Chem Toxicol","ISSN":"https:\/\/id.crossref.org\/issn\/0278-6915","issn-type":"print"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1590\/S0102-86502010000200010","article-title":"The effect of copaiba balsam on Walker 256 carcinoma inoculated into the vagina and uterine cervix of female rats","volume":"25","author":"Brito NMB","year":"2010","journal-title":"Acta Cir Bras"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1590\/S0102-86502000000400008","article-title":"Modelo experimental de tumor de Walker","volume":"15","author":"Moraes SP","year":"2000","journal-title":"Acta Cir Bras"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1590\/S0102-86502006000200009","article-title":"Um novo modelo de isolamento do tumor de Walker utilizando o gradiente de Ficoll-Hypaque","volume":"21","author":"Silva SL","year":"2006","journal-title":"Acta Cir Bras"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.7164\/antibiotics.37.1231","article-title":"Activity of rapamycin (AY-22, 989) against transplanted tumors","volume":"37","author":"Eng CP","year":"1984","journal-title":"J Antibiot"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3923\/pjbs.2007.989.991","article-title":"The study of antioxidant and anticarcinogenic green tea and black tea","volume":"10","author":"Mehrabian S","year":"2007","journal-title":"Pak J Biol Sci"},{"key":"ref12","first-page":"3","article-title":"Prevention of carcinogenesis by tea polyphenols","volume":"33","author":"Yang CS","year":"2001","journal-title":"Drug Metab Rev","ISSN":"https:\/\/id.crossref.org\/issn\/0360-2532","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3431S","DOI":"10.1093\/jn\/134.12.3431S","article-title":"A Review of the health effects of green tea catechins in vivo animal models","volume":"134","author":"Crespy V","year":"2004","journal-title":"J Nutr","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3166","issn-type":"print"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/IGC.0b013e3181c7ca5c","article-title":"Green tea compound in chemoprevention of cervical cancer","volume":"20","author":"Zou C","year":"2010","journal-title":"Int J Gynecol Cancer"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3390\/12050946","article-title":"Cancer preventive mechanisms of the green tea polyphenol (-)-epigallocatechin-3-gallate","volume":"12","author":"Chen L","year":"2007","journal-title":"Molecules","ISSN":"https:\/\/id.crossref.org\/issn\/1420-3049","issn-type":"print"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nrc2641","article-title":"Cancer prevention by tea: animal studies, molecular mechanisms and human relevance","volume":"9","author":"Yang CS","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2174\/1568011023353930","article-title":"Green tea catechins as novel antitumor and antiangiogenic compounds","volume":"2","author":"Demeule M","year":"2002","journal-title":"Curr Med Chem Anticancer Agents"}],"container-title":["Acta Cirurgica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/acb\/v27n9\/v27n9a08.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T05:39:14Z","timestamp":1562132354000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502012000900008&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0102-86502012000900008"],"URL":"https:\/\/doi.org\/10.1590\/s0102-86502012000900008","relation":{},"ISSN":["0102-8650"],"issn-type":[{"value":"0102-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}