{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:34:20Z","timestamp":1762954460061},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>The aim of this study was to assess histologically the effect of LLLT (l 830 nm) on the repair of standardized bone defects on the femur of Wistar albinus rats which were grafted with inorganic bovine bone Gen-ox\u00ae. Three randomized groups were studied: group I (control, n=6); group II (Gen-ox\u00ae, n=9) and group III (Gen-ox\u00ae + LLLT, n=9). The animals were irradiated every 48 h during 15 days; the first irradiation was performed immediately after the procedure. The animals were irradiated transcutaneuosly at four points around the defect. At each point a dose of 4 J\/cm\u00b2 was given (\u00d8~0.6 mm, 40 mW) and the total dose per session was 16 J\/cm\u00b2. The animals were killed by an overdose of general anesthetic 15, 21 and 30 days after surgery. The specimens were routinely processed by embedding in paraffin, serially cut and stained with H&amp;E and Picrosirius and analyzed under light microscopy. The results showed evidence of a more advanced repair in the irradiated group when compared to the non-irradiated groups. The repair of the irradiated group was characterized by both increased bone formation and amount of collagen fibers around the graft within the cavity from the 15th day after surgery, also considering the osteoconductive capacity of the Gen-ox\u00ae. We conclude that LLLT had a positive effect on the repair of bone defects implanted with inorganic bovine bone.<\/jats:p>","DOI":"10.1590\/s0103-64402003000300007","type":"journal-article","created":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T11:04:06Z","timestamp":1113822246000},"page":"177-181","source":"Crossref","is-referenced-by-count":70,"title":["Effect of low level laser therapy on the repair of bone defects grafted with inorganic bovine bone"],"prefix":"10.1590","volume":"14","author":[{"given":"Antonio Luiz Barbosa","family":"Pinheiro","sequence":"first","affiliation":[{"name":"Federal University of Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco de Assis","family":"Limeira J\u00fanior","sequence":"additional","affiliation":[{"name":"Federal University of Bahia, Brazil; Federal University of Paraiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleny Elizabeth M\u00e1rquez","family":"Gerbi","sequence":"additional","affiliation":[{"name":"Federal University of Bahia, Brazil; Federal University of Paraiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Maria Pedreira","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Federal University of Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clovis","family":"Marzola","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Arruda Carneiro","family":"Ponzi","sequence":"additional","affiliation":[{"name":"Federal University of Pernambuco, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"87","article-title":"Comportamento biol\u00f3gico de implantes de osso bovino anorg\u00e2nico em arco zigom\u00e1tico de ratos: Estudo histol\u00f3gico","volume":"25","author":"Rios ALBB","year":"1996","journal-title":"Rev Odontol Univ Est S\u00e3o Paulo"},{"key":"ref2","first-page":"154","article-title":"Alveolar ridge augmentation in rats by Bio-Oss","volume":"99","author":"Pinholt EM","year":"1996","journal-title":"Scand J Dent"},{"key":"ref3","first-page":"904","article-title":"Guided tissue regeneration associated with bovine-derived anorganic bone in mandibular class II furcation defects","volume":"71","author":"Simonpietri JJ","year":"2000","journal-title":"6-month results at re-entry. J Periodontol"},{"key":"ref4","series-title":"Avalia\u00e7\u00e3o microsc\u00f3pica do processo de reparo em cavidades \u00f3sseas submetidas a implante de osso liofilizado bovino (Bio-Oss\u00ae) em f\u00eamur de ratas","author":"Batista PS"},{"key":"ref5","first-page":"1000","article-title":"Use of bovine-derived anorganic bone associated with guided tissue regeneration in intra-bony defects","volume":"70","author":"Batista J\u00fanior EL","year":"1999","journal-title":"Six-month evaluation at re-entry. J Periodontol"},{"key":"ref6","first-page":"12","article-title":"Biomodula\u00e7\u00e3o da cicatriza\u00e7\u00e3o \u00f3ssea p\u00f3s-implantar com o uso da laserterapia n\u00e3o-cir\u00fargica: Estudo por microscopia eletr\u00f4nica de varredura","volume":"22","author":"Pinheiro ALB","year":"2001","journal-title":"Rev FOUFBA"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/104454702753768061","article-title":"Computerized morphometric assessment of the effect of low-level laser therapy on bone repair: an experimental animal study","volume":"20","author":"Silva J\u00fanior AN","year":"2002","journal-title":"J Clin Laser Med Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1044-5471","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/clm.1997.15.181","article-title":"Low-level laser therapy in management of disorders of the maxillofacial region","volume":"15","author":"Pinheiro ALB","year":"1997","journal-title":"J Clin Laser Med Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1044-5471","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01002772","article-title":"Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections","volume":"11","author":"Junqueira LCU","year":"1979","journal-title":"Histochem J","ISSN":"http:\/\/id.crossref.org\/issn\/0018-2214","issn-type":"print"},{"key":"ref10","first-page":"83","article-title":"Processo de reparo em feridas de extra\u00e7\u00e3o dental ap\u00f3s implante de \"osso anorg\u00e2nico\" - Estudo histol\u00f3gico em ratos","volume":"1","author":"Sanches MG","year":"1972","journal-title":"Rev Fac Odont Ara\u00e7atuba"},{"key":"ref11","series-title":"Enxertos \u00d3sseos e Regenera\u00e7\u00e3o Tecidual Guiada: No\u00e7\u00f5es B\u00e1sicas","author":"Garbin CM","year":"1994"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/(SICI)1096-9101(1996)19:4<458::AID-LSM12>3.0.CO;2-Z","article-title":"Effect of low-power He- Ne laser on fracture healing in rats","volume":"19","author":"David R","year":"1996","journal-title":"Lasers Surg Med","ISSN":"http:\/\/id.crossref.org\/issn\/0196-8092","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/1096-9101(2001)28:1<27::AID-LSM1013>3.0.CO;2-4","article-title":"Low intensity laser therapy (830 nm) in the management of minor post-surgical wounds: a controlled clinical study","volume":"28","author":"Lagan KM","year":"2001","journal-title":"Lasers Surg Med","ISSN":"http:\/\/id.crossref.org\/issn\/0196-8092","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/lsm.1900090214","article-title":"Systemic effects of low-power laser irradiation on the peripheral and central nervous system, cutaneous wounds and burns","volume":"9","author":"Rockhind S","year":"1989","journal-title":"Lasers Surg Med","ISSN":"http:\/\/id.crossref.org\/issn\/0196-8092","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/(SICI)1096-9101(1999)24:3<231::AID-LSM8>3.0.CO;2-#","article-title":"Penetration of the laser light into the skin in vitro","volume":"24","author":"Kol\u00e1rov\u00e1 H","year":"1999","journal-title":"Lasers Surg Med","ISSN":"http:\/\/id.crossref.org\/issn\/0196-8092","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/lsm.1900160404","article-title":"Low-intensity laser therapy: still not an established clinical tool","volume":"16","author":"Basford JR","year":"1995","journal-title":"Lasers Surg Med","ISSN":"http:\/\/id.crossref.org\/issn\/0196-8092","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/(SICI)1096-9101(1998)22:5<281::AID-LSM4>3.0.CO;2-L","article-title":"Laser photostimulation of collagen production in healing rabbit achilles tendons","volume":"22","author":"Reddy GK","year":"1998","journal-title":"Lasers Surg Med","ISSN":"http:\/\/id.crossref.org\/issn\/0196-8092","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1902\/jop.1995.66.2.131","article-title":"Periodontal repair in dogs: recombinant bone morphogenetic protein-2 significantly enhances periodontal regeneration","volume":"66","author":"Sigurdsson TJ","year":"1995","journal-title":"J Periodontol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3492","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/lsm.1062","article-title":"Low-power helium: neon laser irradiation enhances production of vascular endothelial growth factor and promotes growth of endothelial cells in vitro","volume":"28","author":"Kipshidze N","year":"2001","journal-title":"Lasers Surg Med","ISSN":"http:\/\/id.crossref.org\/issn\/0196-8092","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S8756-3282(97)00294-9","article-title":"Low-power laser irradiation stimulates bone nodule formation at early stages of cell culture in rat calvarial cells","volume":"22","author":"Osawa Y","year":"1998","journal-title":"Bone","ISSN":"http:\/\/id.crossref.org\/issn\/8756-3282","issn-type":"print"}],"container-title":["Brazilian Dental Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bdj\/v14n3\/v14n3a07.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T18:32:52Z","timestamp":1550082772000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0103-64402003000300007&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003]]}},"alternative-id":["S0103-64402003000300007"],"URL":"https:\/\/doi.org\/10.1590\/s0103-64402003000300007","relation":{},"ISSN":["0103-6440"],"issn-type":[{"value":"0103-6440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}