{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:20:12Z","timestamp":1791822012598,"version":"4.3.4"},"reference-count":93,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>Apical periodontitis is a group of inflammatory diseases caused by microorganisms (mainly bacteria) infecting the necrotic root canal system. The pathogenesis of different types of apical periodontitis and even the same type in different individuals is unlikely to follow a stereotyped fashion with regard to the involved bacterial mediators. Disease pathogenesis is rather complex and involves a multitude of bacteria- and host-related factors. This review article discusses the bacterial pathogenesis of acute and chronic apical periodontitis, with the main focus on the bacterial mediators conceivably involved in the different stages of the infectious process, including secreted products (enzymes, exotoxins, N-formyl-methionyl-leucyl-phenylalanine peptides, heat-shock proteins and metabolic end-products) and structural components (lipopolysaccharide, peptidoglycan, lipoteichoic acid, lipoproteins, fimbriae, flagella, outer membrane proteins and vesicles, DNA, and exopolysaccharides). Knowledge of the bacterial factors involved in the pathogenesis of apical periodontitis is important to the understanding of the disease process and to help establishing proper therapeutic measures to inactivate this bacterial \"artillery\".<\/jats:p>","DOI":"10.1590\/s0103-64402007000400001","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T23:03:40Z","timestamp":1202943820000},"page":"267-280","source":"Crossref","is-referenced-by-count":135,"title":["Bacterial pathogenesis and mediators in apical periodontitis"],"prefix":"10.1590","volume":"18","author":[{"given":"Jos\u00e9 F.","family":"Siqueira Jr","sequence":"first","affiliation":[{"name":"Est\u00e1cio de S\u00e1 University, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela N.","family":"R\u00f4\u00e7as","sequence":"additional","affiliation":[{"name":"Est\u00e1cio de S\u00e1 University, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1111\/j.1834-7819.2007.tb00524.x","article-title":"A big role for the very small-understanding the endodontic microbial flora","volume":"52","author":"Figdor D","year":"2007","journal-title":"Aust Dent J","ISSN":"https:\/\/id.crossref.org\/issn\/0045-0421","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0099-2399(87)80089-4","article-title":"Light and electron microscopic studies of root canal flora and periapical lesions","volume":"13","author":"Nair PNR","year":"1987","journal-title":"J Endod","ISSN":"https:\/\/id.crossref.org\/issn\/0099-2399","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1067\/moe.2002.119910","article-title":"Patterns of microbial colonization in primary root canal 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