{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:32:51Z","timestamp":1789813971615,"version":"4.0.1"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>The oral lichen planus (OLP) is a chronic inflammatory disease, probably autoimmune, with different clinical forms. The most common types are the reticular and the erosive ones. Apoptosis participates in the destruction of basal keratinocytes, but its role in the perpetuation of the subepithelial lymphocytic infiltrates was not yet investigated. To evaluate the involvement of apoptosis in the epithelium and in subepithelial lymphocytic infiltrates, 15 samples of reticular and erosive OLP and 10 samples of healthy oral mucosa were collected and processed histologically. Apoptosis was quantified in the epithelium and in inflammatory cell infiltrates. TUNEL reaction was used to measure apoptosis in the infiltrates. Erosive OLP showed more intense epithelial apoptosis than reticular OLP and controls. In contrast, apoptosis in the inflammatory cell infiltrates was more frequent in reticular than in erosive OLP. Lymphocytes were the predominant cells within the inflammatory cell infiltrates and were more frequent in erosive OLP than in reticular type. These results suggest that different apoptotic levels are involved in the erosive\/reticular switch in OLP, determining different clinical presentations. In conclusion, decreased apoptosis in inflammatory infiltrates may contribute to the persistence of T lymphocytes, worsening the attack to the epithelium in erosive OLP.<\/jats:p>","DOI":"10.1590\/s0103-64402012000500016","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T20:36:01Z","timestamp":1366144561000},"page":"564-569","source":"Crossref","is-referenced-by-count":18,"title":["A comparative study of apoptosis in reticular and erosive oral lichen planus"],"prefix":"10.1590","volume":"23","author":[{"given":"Juliana M. C.","family":"Brant","sequence":"first","affiliation":[{"name":"Federal University of Minas Gerais,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C\u00e1ssia F.","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helenice A. M.","family":"Grandinetti","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Minas Gerais,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana V.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anilton C.","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2334\/josnusd.51.117","article-title":"Immunohistochemical expression of PCNA, p53, bax and bcl-2 in oral lichen planus and epithelial dysplasia","volume":"51","author":"Sousa FA","year":"2009","journal-title":"J Oral Sci","ISSN":"https:\/\/id.crossref.org\/issn\/1343-4934","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1365-2230.2008.03029.x","article-title":"Increased caspase-3 and altered expression of apoptosis-associated proteins, Bcl-2 and Bax in lichen planus","volume":"34","author":"Abdel-Latif AM","year":"2009","journal-title":"Clin Exp Dermatol","ISSN":"https:\/\/id.crossref.org\/issn\/0307-6938","issn-type":"print"},{"key":"ref3","first-page":"35","article-title":"The characteristics of oral lichen planus","volume":"105","author":"Bogd\u00e1n S","year":"2012","journal-title":"Forgorv Sz"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S0103-64402008000300001","article-title":"Role of Apoptosis in erosive and reticular oral lichen planus exhibiting variable epithelial thickness","volume":"19","author":"Brant JMC","year":"2008","journal-title":"Braz Dent J","ISSN":"https:\/\/id.crossref.org\/issn\/0103-6440","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bjoms.2007.07.199","article-title":"Oral mucosal disease: Lichen planus","volume":"46","author":"Scully C","year":"2008","journal-title":"Br J Oral Maxillofac Sur"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1034\/j.1600-0714.2003.00134.x","article-title":"Erythematous and reticular forms of oral lichen planus oral lichenoid reactions differ in pathological features related to disease activity","volume":"32","author":"Karatsaidis A","year":"2003","journal-title":"J Oral Pathol Med","ISSN":"https:\/\/id.crossref.org\/issn\/0904-2512","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1600-0714.2007.00519.x","article-title":"Survival signaling in keratinocytes of erythematous oral lichen planus","volume":"36","author":"Karatsaidis A","year":"2007","journal-title":"J Oral Pathol Med","ISSN":"https:\/\/id.crossref.org\/issn\/0904-2512","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0714.2005.00373.x","article-title":"Apoptosis of oral epithelial cells in oral lichen planus caused by up regulation of BMP-4","volume":"35","author":"Kim SG","year":"2006","journal-title":"J Oral Pathol Med","ISSN":"https:\/\/id.crossref.org\/issn\/0904-2512","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4103\/0973-029X.84474","article-title":"Oral lichen planus: an update on pathogenesis and treatment","volume":"15","author":"Lavanya N","year":"2011","journal-title":"J Oral Maxillofac pathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1042\/CS20050178","article-title":"Granulocyte apoptosis in the pathogenesis and resolution of lung disease","volume":"110","author":"Bianchi SM","year":"2006","journal-title":"Clin Sci","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9287","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.119.3.493","article-title":"Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation","volume":"119","author":"Gavrieli Y","year":"1992","journal-title":"J Cell Biol","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9525","issn-type":"print"},{"key":"ref12","series-title":"Apoptosis - a practical approach","first-page":"19","volume-title":"Morphological recognition of apoptotic cells","author":"Wilson JW","year":"1999"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1590\/S0102-09352004000300020","article-title":"Determination of the minimal representative number of microscopical fields to quantify apoptosis in canine lymph nodes","volume":"56","author":"Moro L","year":"2004","journal-title":"Arq Bras Med Vet Zootec"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1034\/j.1600-0722.2001.00081.x","article-title":"Apoptosis in oral lichen planus","volume":"109","author":"Neppelberg E","year":"2001","journal-title":"Eur J Oral Sci","ISSN":"https:\/\/id.crossref.org\/issn\/0909-8836","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1601-0825.2003.00998.x","article-title":"Expression of caspase-3 and structural changes associated with apoptotic cell death of keratinocytes in oral lichen planus","volume":"10","author":"Tobon-Arroyave SI","year":"2004","journal-title":"Oral Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1354-523X","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1365-2230.2007.02457.x","article-title":"Significance of liquefaction degeneration in oral lichen planus: a study of its relationship with apoptosis and cell cycle arrest markers","volume":"32","author":"Bascones-Ilundain C","year":"2007","journal-title":"Clin Exp Dermatol","ISSN":"https:\/\/id.crossref.org\/issn\/0307-6938","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00048057","article-title":"Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview","volume":"11","author":"Wyllie AH","year":"1991","journal-title":"Cancer and Metast Rev"},{"key":"ref18","first-page":"357","article-title":"Importance of apoptotic mechanisms in inflammatory infiltrate of oral lichen planus lesions","volume":"26","author":"Bascones-Ilundain C","year":"2006","journal-title":"Anticancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/0250-7005","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.archoralbio.2006.06.007","article-title":"Cell cycle regulating mechanisms in oral lichen planus: Molecular bases in the epithelium predisposed to malignant transformation","volume":"51","author":"Gonzalez-Moles MA","year":"2006","journal-title":"Arch Oral Biol","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9969","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF02409015","article-title":"Ultrastructural identification of apoptotic nuclei using the TUNEL technique","volume":"28","author":"Sanders EJ","year":"1996","journal-title":"Histochem J","ISSN":"https:\/\/id.crossref.org\/issn\/0018-2214","issn-type":"print"},{"key":"ref21","first-page":"219","article-title":"Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques","volume":"71","author":"Gold R","year":"1994","journal-title":"Lab Invest","ISSN":"https:\/\/id.crossref.org\/issn\/0023-6837","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1711700102","article-title":"In situ end labeling detects DNA strand breaks in apoptosis and in other physiological and pathological states","volume":"170","author":"Ansari B","year":"1993","journal-title":"J Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3417","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/002215549804600306","article-title":"TUNEL apoptotic cell detection in tissue sections: critical evaluation and improvement","volume":"46","author":"Labat-Moleur F","year":"1998","journal-title":"J Histochem Cytochem","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1554","issn-type":"print"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr JFR","year":"1972","journal-title":"Brit J Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s004410000193","article-title":"The morphology of apoptosis","volume":"301","author":"Hacker G","year":"2000","journal-title":"Cell Tissue Res","ISSN":"https:\/\/id.crossref.org\/issn\/0302-766X","issn-type":"print"}],"container-title":["Brazilian Dental Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bdj\/v23n5\/v23n05a16.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T11:21:00Z","timestamp":1495884060000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0103-64402012000500016&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0103-64402012000500016"],"URL":"https:\/\/doi.org\/10.1590\/s0103-64402012000500016","relation":{},"ISSN":["0103-6440"],"issn-type":[{"value":"0103-6440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}