{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:52:18Z","timestamp":1771674738882,"version":"3.50.1"},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Bras. Dermatol."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Stevens-Johnson's syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening dermatoses, that lead to keratinocyte apoptosis induced by interactions between Fas (cell death receptor) and soluble Fas-ligand, present in serum of Stevens-Johnson's syndrome \/ toxic epidermal necrolysis patients. Anti-Fas antibodies in intravenous immunoglobulin (IVIG) would block the apoptosis cascade. Three cases of toxic epidermal necrolysis occurred in one male and two female patients, after use of allopurinol, leprosy multidrug therapy concomitant with dipyrone, and diclofenac. The cases were treated with intravenous immunoglobulin 2-3 mg\/kg and prednisone 20-50 mg\/day. The interruption of new lesions outbreak and reepithelization were extremely fast after the use of intravenous immunoglobulin, without adverse effects. Controlled studies are needed to confirm the efficacy of intravenous immunoglobulin in Stevens-Johnson's syndrome \/ toxic epidermal necrolysis, but the results seem promising.<\/jats:p>","DOI":"10.1590\/s0365-05962012000300022","type":"journal-article","created":{"date-parts":[[2012,6,17]],"date-time":"2012-06-17T23:01:43Z","timestamp":1339974103000},"page":"477-481","source":"Crossref","is-referenced-by-count":7,"title":["Treatment of toxic epidermal necrolysis with intravenous immunoglobulin: a series of three cases"],"prefix":"10.1590","volume":"87","author":[{"given":"Cristiane","family":"Comparin","sequence":"first","affiliation":[{"name":"University of Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"Hans Filho","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Carlos","family":"Takita","sequence":"additional","affiliation":[{"name":"University of Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayara de Castro Wiziack","family":"Costa","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta Ayres Ferreira do","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidiane de Oliveira Costa","family":"Nanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1590\/S0365-05962004000400009","article-title":"Rea\u00e7\u00f5es cut\u00e2neas graves adversas a drogas: aspectos relevantes ao diagn\u00f3stico e ao tratamento -Parte I - anafilaxia e rea\u00e7\u00f5es anafilact\u00f3ides, eritrodermias e o espectro cl\u00ednico da s\u00edndrome de Stevens-Johnson & necr\u00f3lise epid\u00e9rmica t\u00f3xica (Doen\u00e7a de Lyell)","volume":"79","author":"Criado PR","year":"2004","journal-title":"An Bras Dermatol","ISSN":"https:\/\/id.crossref.org\/issn\/0365-0596","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1523-1747.2000.00061.x","article-title":"SCORTEN: a severity of illness score for toxic epidermal necrolysis","volume":"115","author":"Bastuji-Garin S","year":"2000","journal-title":"J Invest Dermatol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-202X","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/S0002-9440(10)64284-8","article-title":"Toxic epidermal necrolysis and Stevens-Johnson syndrome are induced by soluble Fas ligand","volume":"162","author":"Abe R","year":"2003","journal-title":"Am J Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2310\/7750.2006.00048","article-title":"Canadian Consensus Statement on the Use of Intravenous Immunoglobulin Therapy in Dermatology","volume":"10","author":"Mydlarski PR","year":"2006","journal-title":"J Cut Med Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.282.5388.490","article-title":"Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin","volume":"282","author":"Viard I","year":"1998","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4067\/S0034-98872009000300009","article-title":"Uso de inmunoglobulina humana endovenosa en pacientes con necrolisis epid\u00e9rmica t\u00f3xica y s\u00edndrome de sobreposici\u00f3n Stevens Johnson necrolisis t\u00f3xica epid\u00e9rmica","volume":"137","author":"Molg\u00f3 M","year":"2009","journal-title":"Rev M\u00e9d Chile"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archderm.139.1.33","article-title":"Intravenous immunoglobulin treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis: a prospective noncomparative study showing no benefit on mortality or progression","volume":"139","author":"Bachot N","year":"2003","journal-title":"Arch Dermatol","ISSN":"https:\/\/id.crossref.org\/issn\/0003-987X","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1001\/archderm.139.1.26","article-title":"Toxic epidermal necrolysis-intravenous immunoglobulin: Treatment of toxic epidermal necrolysis with high-dose intravenous immunoglobulins: multicenter retrospective analysis of 48 consecutive cases","volume":"139","author":"Prins C","year":"2003","journal-title":"Arch Dermatol","ISSN":"https:\/\/id.crossref.org\/issn\/0003-987X","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1684\/ejd.2008.0580","article-title":"Guidelines on the use of high-dose intravenous immunoglobulin in dermatology","volume":"19","author":"Enk A","year":"2009","journal-title":"Eur J Dermatol","ISSN":"https:\/\/id.crossref.org\/issn\/1167-1122","issn-type":"print"},{"key":"ref10","first-page":"229","article-title":"Immunohistochemical evaluation of toxic epidermal necrolysis treated with human intravenous immunoglobulin","volume":"143","author":"Romanelli P","year":"2008","journal-title":"G Ital Dermatol Venereol","ISSN":"https:\/\/id.crossref.org\/issn\/0026-4741","issn-type":"print"}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abd\/v87n3\/v87n3a22.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:00:41Z","timestamp":1747666841000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0365-05962012000300022&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0365-05962012000300022"],"URL":"https:\/\/doi.org\/10.1590\/s0365-05962012000300022","relation":{},"ISSN":["0365-0596"],"issn-type":[{"value":"0365-0596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}