{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:56:00Z","timestamp":1761310560487},"reference-count":11,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sao Paulo Med. J."],"published-print":{"date-parts":[[1995,4]]},"abstract":"<jats:p>The uncertaintties in the ethiological treatment of Chagas' Disease are consequence of the lack of entire knowledge of its pathogeny and the no existence of a healing criterium. There is a consensus that antiparasite drugs should be used in the acute phase of the infection, regardless of the infection route, in new crisis, in patients under immunossuppression and in organs transplantation. There is still controversy regarding subacute, chronic or indetermined phase or cases with mild cardiac\/digestive forms, not included in the situations listed above neither in a research protocol. The treatment includes oral benzonidazol 5 mg\/kg\/day, bid or tid for 60 days. In 71 patients monitored in this fashion, the authors have found 60% of negative xenodiagnostic at the end of treatment. It is still necessary, however, to continue to investigate and accomplishing more randomized trials to confirm the efficacy of such method, and also to try to obtain effective and less toxic agents. It is also fundamental to standardize a more reliable healing criterium.<\/jats:p>","DOI":"10.1590\/s1516-31801995000200020","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T05:48:40Z","timestamp":1244180920000},"page":"867-872","source":"Crossref","is-referenced-by-count":18,"title":["Ethiological treatment of acute and chronic Chagas' heart disease"],"prefix":"10.1590","volume":"113","author":[{"given":"Ab\u00edlio Augusto","family":"Fragata Filho","sequence":"first","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Aur\u00e9lio Dias da","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Boainain","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"32","article-title":"Evaluaci\u00f3n del alopurinol en le enfermedad de Chagas' cronica humana en Chile","volume":"11","author":"AGUILERA X.","year":"1987","journal-title":"Parasitol","ISSN":"http:\/\/id.crossref.org\/issn\/0031-1820","issn-type":"print"},{"key":"ref2","first-page":"203","article-title":"Tryposonomiase e cardiopatia chag\u00e1sica cr\u00f4nica","volume":"61","author":"BELLOTTI G.","year":"1993","journal-title":"Arq Bras Cardiol","ISSN":"http:\/\/id.crossref.org\/issn\/0066-782X","issn-type":"print"},{"key":"ref3","series-title":"Tratamento etiol\u00f3gico nas doen\u00e7as de Chagas na fase cr\u00f4nica","author":"BOAINAIN E.","year":"1977"},{"key":"ref4","first-page":"4","article-title":"Atividade terap\u00eautica do 5-nitro-futalde\u00eddo semi-carbozona (nitrofurazona) em esquemas de dura\u00e7\u00e3o prolongada na infec\u00e7\u00e3o experimental do camundongo pelo Trypanosonia cruzi","volume":"3","author":"BRENER Z.","year":"1961","journal-title":"Rev Inst Med Trop S\u00e3o Paulo","ISSN":"http:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref5","series-title":"Chagas' Disease (American Tryposonomiasis): His impact on transfusion and clinical medicine","first-page":"31","volume-title":"Immune response and immunepathology in T cruzi infection","volume":"92","author":"BRENER Z."},{"key":"ref6","first-page":"243","article-title":"Itraconazol in treatment of Chronic Chagas' disease","volume":"88","author":"FRAGATTA F\u00ba. A.A.","year":"1993","journal-title":"Men Inst Oswaldo Cruz"},{"key":"ref7","first-page":"242","article-title":"Allopurinol riboside in Chronic Chagas' Disease","volume":"88","author":"FRAGATTA F\u00ba. A.A.","year":"1993","journal-title":"Nom Inst Oswaldo Cruz"},{"key":"ref8","first-page":"201","article-title":"Terap\u00eautica da Doen\u00e7a de Chagas': Consensos e Diverg\u00eancias","volume":"61","author":"MALTA J.","year":"1993","journal-title":"Arq Bras Cardiol","ISSN":"http:\/\/id.crossref.org\/issn\/0066-782X","issn-type":"print"},{"key":"ref9","first-page":"12","article-title":"Chemotherapy of experimental Chagas' disease with nitrofuran compounds","volume":"7","author":"PACKCHANIAN A.O.","year":"1957","journal-title":"Antibiotic and Chemother"},{"key":"ref10","series-title":"Chagas' Disease (American Tryposonomiasis): His impact on transfusion and clinical medicine","first-page":"31","volume-title":"Therapy of Chagas' Disease","volume":"92","author":"RASSI A."},{"key":"ref11","first-page":"886","article-title":"Endocarditic parietale dans la maladie de Chagas","volume":"99","author":"TORRES C.M.","year":"1928","journal-title":"CR Soc Biol"}],"container-title":["Sao Paulo Medical Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/spmj\/v113n2\/v113n2a18.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T08:17:32Z","timestamp":1495786652000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1516-31801995000200020&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,4]]}},"alternative-id":["S1516-31801995000200020"],"URL":"https:\/\/doi.org\/10.1590\/s1516-31801995000200020","relation":{},"ISSN":["1516-3180"],"issn-type":[{"value":"1516-3180","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,4]]}}}