{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:05:29Z","timestamp":1793304329542,"version":"4.5.0"},"reference-count":40,"publisher":"EDITORA SCIENTIFIC","issue":"2","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"vor","delay-in-days":437,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Revista Brasileira de Psiquiatria"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1590\/s1516-44462012000200009","type":"journal-article","created":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T12:36:33Z","timestamp":1340195793000},"page":"168-175","source":"Crossref","is-referenced-by-count":11,"title":["Energy metabolism, leptin, and biochemical parameters are altered in rats subjected to the chronic administration of olanzapine"],"prefix":"10.47626","volume":"34","author":[{"given":"Alexandra I.","family":"Zugno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariely","family":"Barcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Canever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata D. de","family":"Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiane B.","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paula","family":"Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine T.","family":"Rezin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselli","family":"Scaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio","family":"B\u00farigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio L.","family":"Streck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Quevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27448","reference":[{"key":"10.1590\/S1516-44462012000200009_bib1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1590\/S0101-60832007000800003","article-title":"Avalia\u00e7\u00e3o do comprometimento funcional na esquizofrenia","volume":"34","author":"Sa Junior","year":"2007","journal-title":"Rev Psiq Cl\u00edn"},{"issue":"4","key":"10.1590\/S1516-44462012000200009_bib2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/brain\/122.4.593","article-title":"The neuropathology of schizophrenia: a critical review of the data and their interpretation","volume":"122","author":"Harrison","year":"1999","journal-title":"Brain"},{"issue":"1","key":"10.1590\/S1516-44462012000200009_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1590\/S1516-44462008000100014","article-title":"Consenso brasileiro sobre antipsic\u00f3ticos de segunda gera\u00e7\u00e3o e dist\u00farbios metab\u00f3licos","volume":"30","author":"Elkis","year":"2008","journal-title":"Rev Bras Psiquitr"},{"issue":"2","key":"10.1590\/S1516-44462012000200009_bib4","first-page":"20","article-title":"S\u00edndrome neurol\u00e9ptica maligna de paciente em uso de olanzapina","volume":"57","author":"Medeiros","year":"2008","journal-title":"J Bras Psiq"},{"issue":"1\u20132","key":"10.1590\/S1516-44462012000200009_bib5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neulet.2004.09.032","article-title":"Haloperidol and clozapine, but not olanzapine, induces oxidative stress in rat brain","volume":"372","author":"Reinke","year":"2004","journal-title":"Neurosc Lett"},{"issue":"2","key":"10.1590\/S1516-44462012000200009_bib6","first-page":"36","article-title":"Ganho de peso e altera\u00e7\u00f5es metab\u00f3licas em esquizofrenia","volume":"34","author":"Azevedo","year":"2007","journal-title":"Rev Psiq Cl\u00edn"},{"issue":"1","key":"10.1590\/S1516-44462012000200009_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4103\/0019-5359.38920","article-title":"Metabolic comorbidity in schizophrenia","volume":"62","author":"Jacob","year":"2008","journal-title":"Indian J Med Sci"},{"issue":"1","key":"10.1590\/S1516-44462012000200009_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/sj.ijo.0801840","article-title":"Increased visceral fat distribution in drug-na\u00efve and drug-free patients with schizophrenia","volume":"26","author":"Thakore","year":"2002","journal-title":"Int J Obesit Relat Metab Disord"},{"issue":"1","key":"10.1590\/S1516-44462012000200009_bib9","first-page":"19","article-title":"Antipsic\u00f3ticos at\u00edpicos: farmacologia e uso cl\u00ednico","volume":"22","author":"Oliveira","year":"2000","journal-title":"Rev Bras Psiquiatr"},{"issue":"1","key":"10.1590\/S1516-44462012000200009_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/01.jcp.0000142282.62336.e9","article-title":"Atypical antipsychotic and metabolic dysregulation: evaluating the risk\/benefit equation and improving the standard of care","volume":"24","author":"Nasrallah","year":"2004","journal-title":"J Clin Psychopharmacol"},{"key":"10.1590\/S1516-44462012000200009_bib11","series-title":"A Regula\u00e7\u00e3o em Longo Prazo do Comportamento Alimentar","article-title":"Neuroci\u00eancias: desvendando o sistema nervoso","author":"Bear","year":"2002"},{"issue":"2","key":"10.1590\/S1516-44462012000200009_bib12","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1471-4159.2008.05645.x","article-title":"Leptin protects hippocampal CA1 neurons against ischemic injury","volume":"107","author":"Zhang","year":"2008","journal-title":"J Neurochem"},{"issue":"3","key":"10.1590\/S1516-44462012000200009_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-5793(01)02591-1","article-title":"Insulin modulates leptin-induced STAT3 activation in rat hypothalamus","volume":"500","author":"Carvalheira","year":"2001","journal-title":"FEBS Lett"},{"issue":"3","key":"10.1590\/S1516-44462012000200009_bib14","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/jcp.0b013e3180582412","article-title":"Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population","volume":"27","author":"Zhang","year":"2007","journal-title":"J Clin Psychopharmacol"},{"issue":"3","key":"10.1590\/S1516-44462012000200009_bib15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000099945","article-title":"Rapid leptin elevation after initiation of olanzapine?","volume":"54","author":"Wang","year":"2007","journal-title":"Neuropsychobiol"},{"issue":"1","key":"10.1590\/S1516-44462012000200009_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-2826.2008.01799.x","article-title":"Expression of leptin receptor by glial cells of the nucleus tractus solitaries: possible involvement in energy homeostasis","volume":"21","author":"Dallaporta","year":"2009","journal-title":"J Neuroendocrinol"},{"issue":"5","key":"10.1590\/S1516-44462012000200009_bib17","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.2337\/diacare.26.5.1589","article-title":"New insights on oxidative stress and diabetic complications may lead to a \u201ccausal\u201d antioxidant therapy","volume":"26","author":"Ceriello","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1590\/S1516-44462012000200009_bib18","doi-asserted-by":"crossref","unstructured":"Albaugh VL, Vary TC, Ilkayeva O, Wenner BR, Maresca KP, Joyal JL, Breazeale S, Elich TD, Lang CH, Lynch CJ. Atypical Antipsychotics Rapidly and Inappropriately Switch Peripheral Fuel Utilization to Lipids, Impairing Metabolic Flexibility in Rodents. Schizop Bull. 2010: in press.","DOI":"10.1093\/schbul\/sbq053"},{"issue":"1\u20132","key":"10.1590\/S1516-44462012000200009_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1023\/B:MCBI.0000049374.52989.9b","article-title":"Regional differences in oxidative capacity of rat white adipose tissue are linked to the mitochondrial content of mature adipocytes","volume":"267","author":"Deveaud","year":"2004","journal-title":"Mol Cell Biochem"},{"issue":"4","key":"10.1590\/S1516-44462012000200009_bib20","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0028-3908(98)00215-9","article-title":"Inhibition of mitochondrial complex I by haloperidol: the role of thiol oxidation","volume":"38","author":"Balijepalli","year":"1999","journal-title":"Neuropharmacol"},{"key":"10.1590\/S1516-44462012000200009_bib21","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0197-0186(00)00108-X","article-title":"Protein thiol oxidation by haloperidol results in inhibition of mitochondrial complex I in brain regions: comparison with atypical antipsychotics","volume":"38","author":"Balijepalli","year":"2001","journal-title":"Neurochem Int"},{"issue":"7","key":"10.1590\/S1516-44462012000200009_bib22","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1021\/pr800876z","article-title":"A comparative proteomics analysis of rat mitochondria from the cerebral cortex and hippocampus in response to antipsychotic medications","volume":"8","author":"Ji","year":"2009","journal-title":"J Proteome Res"},{"issue":"6","key":"10.1590\/S1516-44462012000200009_bib23","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1046\/j.1471-4159.2002.01263.x","article-title":"Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine","volume":"83","author":"Ben-Shachar","year":"2002","journal-title":"J Neurochem"},{"issue":"10","key":"10.1590\/S1516-44462012000200009_bib24","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.bcp.2004.02.015","article-title":"Dopamine toxicity involves mitochondrial complex I inhibition: implications to dopamine-related neuropsychiatric disorders","volume":"67","author":"Ben-Shachar","year":"2004","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1590\/S1516-44462012000200009_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0009-8981(94)90055-8","article-title":"Biochemical and molecular investigations in respiratory chain deficiencies","volume":"228","author":"Rustin","year":"1994","journal-title":"Clin Chim Acta"},{"issue":"1","key":"10.1590\/S1516-44462012000200009_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1590\/S1516-44462012000200009_bib27","first-page":"186","article-title":"Efeitos adversos metab\u00f3licos de antipsic\u00f3ticos e estabilizadores de humor","volume":"28","author":"Teixeira","year":"2006","journal-title":"Rev Psiq RG"},{"issue":"11","key":"10.1590\/S1516-44462012000200009_bib28","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1001\/archpsyc.59.11.1021","article-title":"An assessment of the independent effects of olanzapine and risperidone exposure on the risk of hyperlipemia in schizophrenia patients","volume":"59","author":"Koro","year":"2002","journal-title":"Arch Gen Psychiat"},{"issue":"9","key":"10.1590\/S1516-44462012000200009_bib29","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1176\/ajp.156.9.1471-a","article-title":"Olanzapine-induced elevation of plasma triglyceride levels","volume":"156","author":"Sheitman","year":"1999","journal-title":"Am J Psychiat"},{"issue":"4","key":"10.1590\/S1516-44462012000200009_bib30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1590\/S1516-44462003000400014","article-title":"Diabetes mellitus e antipsic\u00f3ticos at\u00edpicos","volume":"25","author":"Sena","year":"2003","journal-title":"Rev Bras Psiquiat"},{"issue":"3","key":"10.1590\/S1516-44462012000200009_bib31","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s10517-008-0294-0","article-title":"Contribution of leptin to the formation of neuroleptic obesity in patients with schizophrenia during antipsychotic therapy","volume":"146","author":"Gorobets","year":"2008","journal-title":"Bull Exp Biol Med"},{"issue":"4","key":"10.1590\/S1516-44462012000200009_bib32","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00213-006-0368-5","article-title":"Chronic administration of olanzapine induces metabolic and food intake alterations: a mouse model of the atypical antipsychotic-associated adverse effects","volume":"186","author":"Coccurello","year":"2006","journal-title":"Psychopharmacol"},{"issue":"7\u20138","key":"10.1590\/S1516-44462012000200009_bib33","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1345\/aph.19327","article-title":"Olanzapine-induced glucose dysregulation","volume":"34","author":"Bettinger","year":"2000","journal-title":"Ann Pharmacother"},{"issue":"1","key":"10.1590\/S1516-44462012000200009_bib34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.schres.2004.10.012","article-title":"The soluble leptin receptor in olanzapine-induced weight gain: results from a prospective study","volume":"75","author":"Ebenbichler","year":"2005","journal-title":"Schizop Res"},{"issue":"3","key":"10.1590\/S1516-44462012000200009_bib35","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000099945","article-title":"Rapid leptin elevation after initiation of olanzapine?","volume":"54","author":"Wang","year":"2006","journal-title":"Neuropsychobiol"},{"issue":"1","key":"10.1590\/S1516-44462012000200009_bib36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0193-953X(02)00035-7","article-title":"Understanding the new and evolving profile of adverse drug effects in schizophrenia","volume":"26","author":"Donna","year":"2003","journal-title":"Psychiat Clin North Am"},{"issue":"6","key":"10.1590\/S1516-44462012000200009_bib37","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.pnpbp.2008.03.015","article-title":"Effects of second generation antipsychotics on leptin and ghrelin","volume":"32","author":"Danaci","year":"2008","journal-title":"Neuro-Psychopharmacol & Biol Psychiat"},{"issue":"6","key":"10.1590\/S1516-44462012000200009_bib38","doi-asserted-by":"crossref","first-page":"L1021","DOI":"10.1007\/s11064-008-9865-8","article-title":"Mitchondrial dysfunction and psychiatric disorders","volume":"34","author":"Rezin","year":"2009","journal-title":"Neurochem Res"},{"issue":"6421","key":"10.1590\/S1516-44462012000200009_bib39","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/362628a0","article-title":"Body mass dependence of H+ leak in mitochondria and its relevance to metabolic rate","volume":"362","author":"Porter","year":"1993","journal-title":"Nat"},{"issue":"1\u20132","key":"10.1590\/S1516-44462012000200009_bib40","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00210-007-0178-2","article-title":"Effect of antipsychotics on succinate dehydrogenase and cytochrome oxidase activities in rat brain","volume":"376","author":"Streck","year":"2007","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"}],"container-title":["Revista Brasileira de Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rbp\/v34n2\/v34n2a09.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T20:20:58Z","timestamp":1687551658000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1516444612700351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S1516444612700351"],"URL":"https:\/\/doi.org\/10.1590\/s1516-44462012000200009","relation":{},"ISSN":["1516-4446"],"issn-type":[{"value":"1516-4446","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}