{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:56:39Z","timestamp":1777100199963,"version":"3.51.4"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"abstract":"<jats:p>ABSTRACT Candidemia is a leading cause of bloodstream infection\u2013associated morbidity and mortality, particularly among critically ill patients. Time to detection (TTD) is crucial, but standard blood culture systems often fail to recover yeasts, filamentous fungi, or identify fungi in polymicrobial infections. The BD BACTEC\u2122 Mycosis IC\/F bottle was designed to improve fungal detection, yet comparative performance data are limited. This study aimed to compare the detection rate and TTD of BD BACTEC\u2122 Mycosis IC\/F with those of standard BD BACTEC\u2122 Plus Aerobic\/F and BD BACTEC\u2122 Plus Anaerobic\/F bottles using simulated models of fungemia and mixed fungal\u2013bacterial bloodstream infections. This in vitro study included 333 blood culture bottles inoculated with Candida spp., Cryptococcus neoformans, Trichosporon asahii, Fusarium spp., and Aspergillus terreus, as well as bottles simulating coinfections with multidrug-resistant Gram-negative bacteria. All bottles were incubated in the BD BACTEC\u2122 FX system for up to 14 days. BD BACTEC\u2122 Mycosis IC\/F achieved 100% detection for Candida spp., outperforming BD BACTEC\u2122 Plus Anaerobic\/F (58.5%) and matching BD BACTEC\u2122 Plus Aerobic\/F. It showed shorter TTDs for Nakaseomyces glabratus, Candidozyma haemuli, Meyerozyma guilliermondii, and molds. In mixed infections, BD BACTEC\u2122 Mycosis IC\/F provided better fungal recovery, especially at low inocula, although recovery was impaired when coinoculated with carbapenemase-producing bacteria. In conclusion, BD BACTEC\u2122 Mycosis IC\/F improved fungal detection and recovery compared with standard bottles, including in polymicrobial settings. Its use may enhance diagnostic yield in suspected fungemia, though cost and limited availability may limit widespread adoption.<\/jats:p>","DOI":"10.1590\/s1678-9946202567064","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T15:06:50Z","timestamp":1759504010000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparative performance of BD-BACTEC\u00ae Mycosis IC\/F versus standard aerobic and anaerobic bottles in simulated fungemia and mixed bloodstream infections"],"prefix":"10.1590","volume":"67","author":[{"given":"Juliene Carla Endo","family":"Borges","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lumena Pereira Machado","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1112-081X","authenticated-orcid":false,"given":"Vera Lucia Teixeira de","family":"Freitas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-389X","authenticated-orcid":false,"given":"V\u00edtor Falc\u00e3o de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Satie Gon\u00e7alves Kono","family":"Magri","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afonso Rafael da","family":"Silva Junior","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelina da Motta Pacheco Alves de","family":"Araujo","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-9781","authenticated-orcid":false,"given":"Ana Paula","family":"Cury","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7996-8265","authenticated-orcid":false,"given":"Marcello Mihailenko Chaves","family":"Magri","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1016\/S1473-3099(24)00749-7","article-title":"Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM","volume":"25","author":"Cornely OA","year":"2025","journal-title":"Lancet Infect Dis"},{"key":"ref2","article-title":"Prognostic trends and current challenges in candidemia: a comparative analysis of two multicenter cohorts within the past decade","volume":"9","author":"Agnelli C","year":"2023","journal-title":"J Fungi (Basel)"},{"key":"ref3","article-title":"Epidemiological assessment and risk factors for mortality of bloodstream infections by Candida sp. and the impact of the COVID-19 pandemic era","volume":"10","author":"Araujo JM","year":"2024","journal-title":"J Fungi 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