{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:03:00Z","timestamp":1782363780885,"version":"3.54.5"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Einstein (S\u00e3o Paulo)"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>OBJECTIVE: To compare two oncotic cervical cytology techniques, the conventional and the liquid-based cytology, in low risk patients for uterine cervical cancer. METHODS: Comparative prospective study with 100 patients who came to their annual gynecological exam, and were submitted simultaneously to both techniques. We used the McNemar test, with a significance level of p&lt;0.05 to compare the results obtained related to adequacy of the smear quality, descriptive diagnosis prevalence, guided biopsy confirmation and histology. RESULTS: Adequacy of the smear was similar for both methods. The quality with squamocolumnar junction in 93% of conventional cytology and in 84% of the liquid-based cytology had statistical significance. As for the diagnosis of atypical cells they were detected in 3% of conventional cytology and in 10% of liquidbased cytology (p=0.06). Atypical squamous cells of undetermined significance were the most prevalent abnormality. The liquid-based cytology performance was better when compared with colposcopy (guided biopsy), presenting sensitivity of 66.7% and specificity of 100%. There was no cytological and histological concordance for the conventional cytology. CONCLUSIONS: Liquid-based cytology had a better performance to diagnose atypical cells and the cytohistological concordance was higher than in the conventional cytology.<\/jats:p>","DOI":"10.1590\/s1679-45082012000400013","type":"journal-article","created":{"date-parts":[[2013,1,26]],"date-time":"2013-01-26T10:31:26Z","timestamp":1359196286000},"page":"466-472","source":"Crossref","is-referenced-by-count":14,"title":["Comparative study of the results from conventional cervico-vaginal oncotic cytology and liquid-based cytology"],"prefix":"10.1590","volume":"10","author":[{"given":"Sueli Aparecida Batista","family":"Stabile","sequence":"first","affiliation":[{"name":"Instituto de Assist\u00eancia M\u00e9dica ao Servidor P\u00fablico Estadual, Brazil; Hospital C\u00e2ndido Rondon, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilson Henrique Ramos","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Universidade Federal de Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdely Helena","family":"Talamonte","sequence":"additional","affiliation":[{"name":"Instituto de Assist\u00eancia M\u00e9dica ao Servidor P\u00fablico Estadual, Brazil; Hospital C\u00e2ndido Rondon, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto Gazi","family":"Lippi","sequence":"additional","affiliation":[{"name":"Universidade Federal de Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginaldo Guedes Coelho","family":"Lopes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Patologia do trato genital inferior","author":"Martins NV","year":"2005"},{"key":"ref2","series-title":"Citopatologia ginecol\u00f3gica com correla\u00e7\u00f5es histol\u00f3gicas e clinicas","author":"Koss LG","year":"2006"},{"key":"ref3","series-title":"Estimativa para 2012 do C\u00e2ncer do colo uterino no Brasil e diferentes regi\u00f5es"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/oxfordjournals.aje.a117485","article-title":"Meta-analysis of Pap test accuracy","volume":"141","author":"Fahey MT","year":"1995","journal-title":"Am J Epidemiol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9262","issn-type":"print"},{"issue":"8","key":"ref5","first-page":"479","article-title":"Fatores associados a resultados falso negativos de exames citopatol\u00f3gicos do colo uterino","volume":"28","author":"Franco R","year":"2006","journal-title":"Rev Bras Ginecol Obstet","ISSN":"https:\/\/id.crossref.org\/issn\/0100-7253","issn-type":"print"},{"key":"ref6","series-title":"Compara\u00e7\u00e3o do desempenho do esfrega\u00e7o citol\u00f3gico c\u00e9rvicovaginal convencional com esfrega\u00e7o colhido em meio l\u00edquido em mulheres com alto risco para neoplasia de colo uterino","author":"Guedes AC"},{"key":"ref7","first-page":"119","article-title":"Citologia em base l\u00edquida: uma nova op\u00e7\u00e3o para o diagn\u00f3stico de les\u00f5es bucais","volume":"4","author":"Campagnoli EB","year":"2005","journal-title":"Rev Bras Patol Oral"},{"issue":"2","key":"ref8","first-page":"132","article-title":"Accuracy of liquidbased Pap tests: comparison of concurrent liquid-based tests and cervical biopsies on 782 women with previously abnormal Pap smears","volume":"49","author":"Guo M","year":"2005","journal-title":"Acta Cytol","ISSN":"https:\/\/id.crossref.org\/issn\/0001-5547","issn-type":"print"},{"issue":"20","key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta8200","article-title":"Liquid-based cytology in cervical screening: an updated rapid and systematic review and economic analysis","volume":"8","author":"Karnon J","year":"2004","journal-title":"Health Technol Assess","ISSN":"https:\/\/id.crossref.org\/issn\/1366-5278","issn-type":"print"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1111\/j.1471-0528.2008.01865.x","article-title":"A randomised comparison of SurePath liquid-based cytology and conventional smear cytology in a colposcopy clinic setting","volume":"115","author":"Sykes PH","year":"2008","journal-title":"BJOG"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.53393\/rial.2003.62.34949","article-title":"Avalia\u00e7\u00e3o da celularidade citol\u00f3gica em preparados de base l\u00edquida","volume":"62","author":"Pereira SM","year":"2003","journal-title":"Rev Inst Adolfo Lutz","ISSN":"https:\/\/id.crossref.org\/issn\/0073-9855","issn-type":"print"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/dc.10409","article-title":"Cervical biopsy-based comparison of a new liquidbased thin-layer preparation with conventional Pap smears","volume":"30","author":"Mattosinho de Castro Ferraz M da G","year":"2004","journal-title":"Diagn Cytopathol","ISSN":"https:\/\/id.crossref.org\/issn\/8755-1039","issn-type":"print"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2303.2006.00279.x","volume":"17","author":"Alves VA","year":"2006","journal-title":"Cytopathology","ISSN":"https:\/\/id.crossref.org\/issn\/0956-5507","issn-type":"print"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.32635\/2176-9745.RBC.2004v50n3.2027","article-title":"Compara\u00e7\u00e3o do desempenho do teste de captura h\u00edbrida II para HPV, citologia em meio l\u00edquido e citologia convencional na detec\u00e7\u00e3o precoce do c\u00e2ncer do colo do \u00fatero e de suas les\u00f5es precursoras no Rio de Janeiro, Brasil","volume":"50","author":"Girianelli VR","year":"2004","journal-title":"Rev Bras Cancerol","ISSN":"https:\/\/id.crossref.org\/issn\/0034-7116","issn-type":"print"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ygyno.2005.01.013","article-title":"DCS liquid-based system is more effective than conventional smears to diagnosis of cervical lesions: Study in high-risk population with biopsy-based confirmation","volume":"97","author":"Longatto Filho A","year":"2005","journal-title":"Gynecol Oncol","ISSN":"https:\/\/id.crossref.org\/issn\/0090-8258","issn-type":"print"},{"issue":"7609","key":"ref16","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.39219.645475.55","article-title":"Accuracy of reading liquid based cytology slides using the ThinPrep Imager compared with conventional cytology: prospective study","volume":"335","author":"Davey E","year":"2007","journal-title":"BMJ","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"issue":"1","key":"ref17","first-page":"157","article-title":"A comparison of liquid-based cytology and Pap smear as a screening method for cervical cancer","volume":"18","author":"Zhu J","year":"2007","journal-title":"Oncol Rep","ISSN":"https:\/\/id.crossref.org\/issn\/1021-335X","issn-type":"print"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000325754","article-title":"Effectiveness of liquid-based cytology and papanicolaou tests in a low risk populations","volume":"51","author":"Lerma E","year":"2007","journal-title":"Acta Cytol","ISSN":"https:\/\/id.crossref.org\/issn\/0001-5547","issn-type":"print"},{"issue":"1","key":"ref19","first-page":"1","article-title":"Comparison of conventional Papanicolau smears and fluid-based, thin-layer cytology with colposcopic biopsy control in central Italy: a consecutive sampling study of 461 cases","volume":"37","author":"Rahimi S","year":"2008","journal-title":"Diagn Cythopathol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2303.2006.00384.x","article-title":"Comparison of conventional Papanicolaou smear and SurePath liquid-based cytology in the Copenhagen population screening programme for cervical cancer","volume":"17","author":"Kirschner B","year":"2006","journal-title":"Cytopathology","ISSN":"https:\/\/id.crossref.org\/issn\/0956-5507","issn-type":"print"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-7-191","article-title":"The impact of the introduction of liquid based cytology on the variation in the proportion of inadequate samples between GP practices","volume":"7","author":"Harrison WN","year":"2007","journal-title":"BMC Public Health"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1365-2303.2006.00339.x","article-title":"Liquid-based cytology and conventional smears compared over two 12-month periods","volume":"17","author":"Williams AR","year":"2006","journal-title":"Cytopathology","ISSN":"https:\/\/id.crossref.org\/issn\/0956-5507","issn-type":"print"},{"issue":"7609","key":"ref23","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.39196.740995.BE","article-title":"Accuracy of liquid based versus conventional cytology: overall results of new technologies for cervical cancer screening: randomized controlled trial","volume":"335","author":"Ronco G","year":"2007","journal-title":"BMJ","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/cncr.22953","article-title":"Liquid-based cytology versus conventional Papanicolaou smear in an organized screening program: a prospective randomized study","volume":"111","author":"Strander B","year":"2007","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ygyno.2008.12.012","article-title":"Superior performance of liquid-based versus conventional cytology in a population-based cervical cancer screening program","volume":"112","author":"Beerman H","year":"2009","journal-title":"Gynecol Oncol","ISSN":"https:\/\/id.crossref.org\/issn\/0090-8258","issn-type":"print"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0090-8258(03)00176-8","article-title":"Performance of ThinPrep liquid-based cervical cytology in comparison with conventionally prepared Papanicolaou smears: a quantitative survey","volume":"90","author":"Abulafia O","year":"2003","journal-title":"Gynecol Oncol","ISSN":"https:\/\/id.crossref.org\/issn\/0090-8258","issn-type":"print"},{"issue":"9505","key":"ref27","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0140-6736(06)67961-0","article-title":"Effect of study design and quality on unsatisfactory rates, cytology classifications, and accuracy in liquid-based versus conventional cervical cytology: a systematic review","volume":"367","author":"Davey E","year":"2006","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/01.AOG.0000296488.85807.b3","article-title":"Liquid compared with conventional cervical cytology: a systematic review and meta-analysis","volume":"111","author":"Arbyn M","year":"2008","journal-title":"Obstet Gynecol","ISSN":"https:\/\/id.crossref.org\/issn\/0029-7844","issn-type":"print"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/GRF.0b013e31804a8285","article-title":"Cervical cancer screening in the 21st century: is it time to retire the Pap smear?","volume":"50","author":"Wright TC Jr","year":"2007","journal-title":"Clin Obstet Gynecol","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9201","issn-type":"print"}],"container-title":["Einstein (S\u00e3o Paulo)"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/eins\/v10n4\/v10n4a13.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T06:40:55Z","timestamp":1714891255000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1679-45082012000400013&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1679-45082012000400013"],"URL":"https:\/\/doi.org\/10.1590\/s1679-45082012000400013","relation":{},"ISSN":["1679-4508"],"issn-type":[{"value":"1679-4508","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}