{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:27:49Z","timestamp":1793831269220,"version":"4.6.1"},"reference-count":55,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Einstein (S\u00e3o Paulo)"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>ABSTRACT Heart transplantation is currently the definitive gold standard surgical approach in the treatment of refractory heart failure. However, the shortage of donors limits the achievement of a greater number of heart transplants, in which the use of mechanical circulatory support devices is increasing. With well-established indications and contraindications, as well as diagnosis and treatment of rejection through defined protocols of immunosuppression, the outcomes of heart transplantation are very favorable. Among early complications that can impact survival are primary graft failure, right ventricular dysfunction, rejection, and infections, whereas late complications include cardiac allograft vasculopathy and neoplasms. Despite the difficulties for heart transplantation, in particular, the shortage of donors and high mortality while on the waiting list, in Brazil, there is a great potential for both increasing effective donors and using circulatory assist devices, which can positively impact the number and outcomes of heart transplants.<\/jats:p>","DOI":"10.1590\/s1679-45082015rw3154","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T22:10:45Z","timestamp":1436047845000},"page":"310-318","source":"Crossref","is-referenced-by-count":56,"title":["Heart transplantation: review"],"prefix":"10.1590","volume":"13","author":[{"given":"Sandrigo","family":"Mangini","sequence":"first","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Rubim","family":"Alves","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Od\u00edlson Marcos","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe Vieira","family":"Pires","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Jos\u00e9 Tachotti","family":"Pires","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Novaes Cardoso","family":"Curiati","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Bacal","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, 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