{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:03:01Z","timestamp":1782316981036,"version":"3.54.5"},"reference-count":14,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Einstein (S\u00e3o Paulo)"],"abstract":"<jats:p>ABSTRACT The ovarian hyperstimulation syndrome is the combination of increased ovarian volume, due to the presence of multiple cysts and vascular hyperpermeability, with subsequent hypovolemia and hemoconcentration. We report a case of spontaneous syndrome in a singleton pregnancy. This was a spontaneous pregnancy with 12 weeks of gestational age. The pregnancy was uneventful until 11 weeks of gestational age. After that, the pregnant woman complained of progressive abdominal distention associated with abdominal discomfort. She did not report other symptoms. In the first trimester, a routine ultrasonography showed enlarged ovaries, multiples cysts and ascites. Upon admission, the patient was hemodynamically stable, her serum \u03b2-hCG was 24,487mIU\/mL, thyroid-stimulating hormone was 2.2\u00b5UI\/mL and free T4 was 1.8ng\/dL. All results were within normal parameters. However, levels of estradiol were high (10,562pg\/mL). During hospitalization, she received albumin, furosemide and prophylactic dose of enoxaparin. The patient was discharged on the sixth hospital day.<\/jats:p>","DOI":"10.1590\/s1679-45082016rc3429","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T11:19:25Z","timestamp":1464002365000},"page":"231-234","source":"Crossref","is-referenced-by-count":9,"title":["Ovarian hyperstimulation syndrome in a spontaneous singleton pregnancy"],"prefix":"10.1590","volume":"14","author":[{"given":"F\u00e1bio Roberto","family":"Cabar","sequence":"first","affiliation":[{"name":"Elo Cl\u00ednica de Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1186\/s13048-014-0106-2","article-title":"Interleukin-2 and SOCS-1 proteins involvement in the pathophysiology of severe ovarian hyperstimulation syndrome--a preliminary proof of concept","volume":"7","author":"Orvieto R","year":"2014","journal-title":"J Ovarian 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