{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:17:20Z","timestamp":1775801840621,"version":"3.50.1"},"reference-count":174,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Einstein (S\u00e3o Paulo)"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>ABSTRACT In the last few years, new primary immunodeficiencies and genetic defects have been described. Recently, immunoglobulin products with improved compositions and for subcutaneous use have become available in Brazil. In order to guide physicians on the use of human immunoglobulin to treat primary immunodeficiencies, based on a narrative literature review and their professional experience, the members of the Primary Immunodeficiency Group of the Brazilian Society of Allergy and Immunology prepared an updated document of the 1st Brazilian Consensus, published in 2010. The document presents new knowledge about the indications and efficacy of immunoglobulin therapy in primary immunodeficiencies, relevant production-related aspects, mode of use (routes of administration, pharmacokinetics, doses and intervals), adverse events (major, prevention, treatment and reporting), patient monitoring, presentations available and how to have access to this therapeutic resource in Brazil.<\/jats:p>","DOI":"10.1590\/s1679-45082017ae3844","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T12:39:25Z","timestamp":1492691965000},"page":"1-16","source":"Crossref","is-referenced-by-count":14,"title":["II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies"],"prefix":"10.1590","volume":"15","author":[{"given":"Ekaterini Sim\u00f5es","family":"Goudouris","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almerinda Maria do Rego","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aluce Loureiro","family":"Ouricuri","sequence":"additional","affiliation":[{"name":"Hospital Servidores do Estado do Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anete Sevciovic","family":"Grumach","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Condino-Neto","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Tavares","family":"Costa-Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma Cec\u00edlia Douglas Paes","family":"Barreto","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio do Estado do Par\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra de Barros","family":"Dorna","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrthes Anna Maragna Toledo","family":"Barros","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma Carvalho Neves","family":"Forte","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"3","key":"ref1","first-page":"104","article-title":"I Consenso Brasileiro sobre o Uso de Imunoglobulina 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