{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:09:36Z","timestamp":1791598176557,"version":"4.3.4"},"reference-count":9,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Einstein (S\u00e3o Paulo)"],"abstract":"<jats:p>ABSTRACT Germ cell tumors are rare neoplasms that mostly occur in the gonads, although they can also affect other body sites, especially the anterior mediastinum (50 to 70% of all extragonadal germ cell tumors). We report a case of a primary mediastinal yolk sac tumor, a rare and aggressive germ cell tumors subtype. This was a 38-year-old man who was admitted to Hospital do Servidor P\u00fablico Estadual \u201cFrancisco Morato de Oliveira\u201d, complaining about dyspnea and dry cough for 1 year. The computed tomography scan of his chest revealed a large mass in the anterior mediastinum with heterogeneous enhancement to the contrast associated with pleural effusion. There were also high serum levels of alpha-fetoprotein. After neoadjuvant chemotherapy, the patient underwent surgical resection of the mass, followed by pathological examination, which confirmed a primary mediastinal yolk sac tumor, a nonseminomatous subtype of germ cell tumors. Primary mediastinal yolk sac tumors have poor prognosis, despite advances in therapy with surgical resection and cisplatin-based chemotherapy. This poor prognosis is due to the degree of invasion and unresectability in most patients by the time of the diagnosis.<\/jats:p>","DOI":"10.1590\/s1679-45082017rc4008","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T23:38:59Z","timestamp":1505950739000},"page":"496-499","source":"Crossref","is-referenced-by-count":8,"title":["Yolk sac primary tumor of mediastino: a rare case in a young adult"],"prefix":"10.1590","volume":"15","author":[{"given":"Lorena Luryann Cartaxo da","family":"Silva","sequence":"first","affiliation":[{"name":"Instituto de Assist\u00eancia M\u00e9dica ao Servidor P\u00fablico Estadual,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Sasaki","family":"Vergilio","sequence":"additional","affiliation":[{"name":"Instituto de Assist\u00eancia M\u00e9dica ao Servidor P\u00fablico Estadual,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diva Carvalho Collarile","family":"Yamaguti","sequence":"additional","affiliation":[{"name":"Instituto de Assist\u00eancia M\u00e9dica ao Servidor P\u00fablico Estadual,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Azevedo Nicodemos da","family":"Cruz","sequence":"additional","affiliation":[{"name":"Instituto de Assist\u00eancia M\u00e9dica ao Servidor P\u00fablico Estadual,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana Angrisani Granato","family":"Queen","sequence":"additional","affiliation":[{"name":"Instituto de Assist\u00eancia M\u00e9dica ao Servidor P\u00fablico Estadual,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"issue":"3","key":"ref1","first-page":"182","article-title":"Primary mediastinal germ cell tumors","volume":"52","author":"Couto WJ","year":"2006","journal-title":"Rev Assoc Med Bras"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.cursur.2004.05.021","article-title":"Anterior mediastinal nonseminomatous germ cell tumor with malignant transformation: a case report","volume":"61","author":"Michel M","year":"2004","journal-title":"Curr Surg"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1699-0463.1967.tb01290.x","article-title":"Primary germ cell tumor of the anterior mediastinum with features of endodermal sinus tumor. (Mesoblastoma vitellinum)","volume":"70","author":"Teilmann I","year":"1967","journal-title":"Acta Pathol Microbiol Scand"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1186\/1756-0500-7-803","article-title":"Complete histologic response to chemotherapy in a patient with a mediastinal yolk sac tumor: a case report","volume":"7","author":"Akasbi Y","year":"2014","journal-title":"BMC Res Notes"},{"issue":"6","key":"ref5","first-page":"831","article-title":"A mediastinal germ cell tumor of yolk sac type--case report","volume":"105","author":"Tinica G","year":"2010","journal-title":"Chirurgia (Bucur)"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1470-2045(04)01385-3","article-title":"Uncommon primary mediastinal tumours","volume":"5","author":"Macchiarini P","year":"2004","journal-title":"Lancet Oncol"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1200\/JCO.2002.07.062","article-title":"Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis","volume":"20","author":"Bokemeyer C","year":"2002","journal-title":"J Clin Oncol"},{"key":"ref8","article-title":"A rare case of primary anterior mediastinal yolk sac tumor in an elderly adult male","volume":"2016","author":"Nakhla SG","year":"2016","journal-title":"Case Rep Oncol Med"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1579-2129(11)70035-0","article-title":"Pulmonary pure yolk-sac tumor. A rare anatomopathological entity","volume":"47","author":"Ram\u00edrez Gil ME","year":"2011","journal-title":"Arch Bronconeumol"}],"container-title":["Einstein (S\u00e3o Paulo)"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/eins\/v15n4\/1679-4508-eins-S1679-45082017RC4008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T02:05:06Z","timestamp":1520301906000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1679-45082017000400496&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,21]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["S1679-45082017000400496"],"URL":"https:\/\/doi.org\/10.1590\/s1679-45082017rc4008","relation":{},"ISSN":["2317-6385","1679-4508"],"issn-type":[{"value":"2317-6385","type":"electronic"},{"value":"1679-4508","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9,21]]}}}