{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T23:28:33Z","timestamp":1658014113468},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>OBJETIVO: Avaliar o impacto de curto prazo do uso de tiotr\u00f3pio em pacientes com DPOC grave e muito grave com queixas de dispneia apesar do tratamento com outros broncodilatadores. M\u00c9TODOS: Estudo prospectivo incluindo pacientes com DPOC grave ou muito grave, com queixa de dispneia de pequenos esfor\u00e7os ou ao repouso. A cada 15 dias, o tratamento broncodilatador foi modificado: salmeterol, tiotr\u00f3pio e associa\u00e7\u00e3o salmeterol+tiotr\u00f3pio. Ao final de cada regime, foram realizados testes de fun\u00e7\u00e3o pulmonar e teste de caminhada de seis minutos (TC6). Tamb\u00e9m foram avaliados o grau de dispneia e a capacidade de realiza\u00e7\u00e3o de atividades de vida di\u00e1ria. Para a avalia\u00e7\u00e3o das atividades de vida di\u00e1ria, foi utilizada a escala London Chest Activity of Daily Living (LCADL) validado para uso no Brasil. RESULTADOS: Foram avaliados 52 pacientes. Desses, 30 completaram o estudo. A introdu\u00e7\u00e3o de tiotr\u00f3pio como monoterapia resultou em uma melhora significativa (p &lt; 0,05) da dispneia basal (m\u00e9dia do escore da escala do Medical Research Council de 3,0 para 2,5) e ao final do TC6 (m\u00e9dia do escore da escala de Borg de 6,1 para 4,5), e as diferen\u00e7as foram significativas (p &lt; 0,05 para ambos). O uso da associa\u00e7\u00e3o salmeterol+tiotr\u00f3pio resultou em um aumento significativo m\u00e9dio de 81 mL no VEF1 e na melhora de 5,7 pontos no escore da escala LCADL. CONCLUS\u00d5ES: A introdu\u00e7\u00e3o de tiotr\u00f3pio no tratamento de pacientes com DPOC grave a muito grave em uso de \u03b22-agonistas de longa dura\u00e7\u00e3o causa melhora na fun\u00e7\u00e3o pulmonar e alivio sintom\u00e1tico percept\u00edvel pelos pacientes a curto prazo. Esses resultados, obtidos em regime de atendimento de vida real, d\u00e3o suporte ao uso da associa\u00e7\u00e3o salmeterol+tiotr\u00f3pio em protocolos de assist\u00eancia espec\u00edficos a esses pacientes.<\/jats:p>","DOI":"10.1590\/s1806-37132010000200005","type":"journal-article","created":{"date-parts":[[2011,4,10]],"date-time":"2011-04-10T18:59:04Z","timestamp":1302461944000},"page":"181-189","source":"Crossref","is-referenced-by-count":3,"title":["Efeito de curto prazo do tiotr\u00f3pio nos portadores de DPOC em tratamento com \u03b22-agonista"],"prefix":"10.1590","volume":"36","author":[{"given":"Frederico Leon Arrabal","family":"Fernandes","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Aparecida Le\u00e3o","family":"Pavezi","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rvulo Azevedo","family":"Dias Jr","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina Maria Carvalho","family":"Pinto","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Stelmach","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Cukier","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","article-title":"Global strategy for the diagnosis, 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