{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T17:09:53Z","timestamp":1672333793156},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>Desde o in\u00edcio do uso de drogas anti-TNF para o tratamento da artrite reumatoide e outras doen\u00e7as inflamat\u00f3rias, casos de tuberculose pulmonar e extrapulmonar v\u00eam sendo notificados em pacientes submetidos a tal tratamento. Na maioria das vezes, a doen\u00e7a se desenvolve durante as seis primeiras infus\u00f5es. Todo paciente deve ser avaliado para tuberculose latente antes do in\u00edcio do uso de um bloqueador de TNF; no entanto, o diagn\u00f3stico de tuberculose latente \u00e9 um desafio. A prova tubercul\u00ednica, o \u00fanico teste dispon\u00edvel para a detec\u00e7\u00e3o de tuberculose latente por quase um s\u00e9culo, apresenta uma s\u00e9rie de limita\u00e7\u00f5es. Testes baseados na detec\u00e7\u00e3o da produ\u00e7\u00e3o de IFN-\u03b3 in vitro por c\u00e9lulas mononucleares ativadas por ant\u00edgenos espec\u00edficos parecem ser mais acurados e v\u00eam sendo pesquisados em pacientes com artrite reumatoide.<\/jats:p>","DOI":"10.1590\/s1806-37132010000200014","type":"journal-article","created":{"date-parts":[[2010,5,13]],"date-time":"2010-05-13T09:55:05Z","timestamp":1273744505000},"page":"243-251","source":"Crossref","is-referenced-by-count":5,"title":["Tuberculose em pacientes com artrite reumatoide: a dificuldade no diagn\u00f3stico da forma latente"],"prefix":"10.1590","volume":"36","author":[{"given":"Daniela Graner Schuwartz Tannus","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Daniella de Souza","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  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