{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:57:02Z","timestamp":1793224622896,"version":"4.5.0"},"reference-count":27,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>As vasculites antineutrophil cytoplasmic antibody (ANCA, anticorpo anticitoplasma de neutr\u00f3filos) associadas (VAAs) s\u00e3o caracterizadas por uma inflama\u00e7\u00e3o sist\u00eamica das art\u00e9rias de pequeno e m\u00e9dio calibre (especialmente no trato respirat\u00f3rio superior e inferior, e nos rins). As VAAs compreendem a granulomatose de Wegener (agora chamada de granulomatose com poliange\u00edte), poliange\u00edte microsc\u00f3pica, VAA limitada ao rim e a s\u00edndrome de Churg-Strauss. Neste artigo, discutiremos as fases de tratamento dessas vasculites, como fase de indu\u00e7\u00e3o (com ciclofosfamida ou rituximab) e fase de manuten\u00e7\u00e3o (com azatioprina, metotrexato ou rituximab). Al\u00e9m disso, discutiremos como manusear os casos refrat\u00e1rios \u00e0 ciclofosfamida.<\/jats:p>","DOI":"10.1590\/s1806-37132011000600016","type":"journal-article","created":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T04:46:25Z","timestamp":1326257185000},"page":"809-816","source":"Crossref","is-referenced-by-count":6,"title":["Atualiza\u00e7\u00e3o do tratamento das vasculites associadas a anticorpo anticitoplasma de neutr\u00f3filos"],"prefix":"10.1590","volume":"37","author":[{"given":"Alfredo Nicodemos Cruz","family":"Santana","sequence":"first","affiliation":[{"name":"Hospital Regional da Asa Norte; Secretaria de Estado da Sa\u00fade,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Woronik","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari Stiel Radu","family":"Halpern","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen S V","family":"Barbas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/art.30286","article-title":"Granulomatosis with polyangiitis (Wegener's): an alternative name for Wegener's granulomatosis","volume":"63","author":"Falk RJ","year":"2011","journal-title":"Arthritis Rheum","ISSN":"https:\/\/id.crossref.org\/issn\/0004-3591","issn-type":"print"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/rheumatology\/kep216","article-title":"Circulating endothelial progenitor cells in ANCA-associated vasculitis: the light at the end of the 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