{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:37:03Z","timestamp":1758814623708},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>OBJETIVO: A asma \u00e9 a doen\u00e7a pulmonar cr\u00f4nica mais comum na inf\u00e2ncia, caracterizada por inflama\u00e7\u00e3o br\u00f4nquica. Algumas crian\u00e7as com asma podem apresentar fun\u00e7\u00e3o pulmonar persistentemente reduzida. A preval\u00eancia e etiologia dessa anormalidade em crian\u00e7as com asma em pa\u00edses em desenvolvimento ainda n\u00e3o s\u00e3o conhecidas. O objetivo deste estudo foi estimar a propor\u00e7\u00e3o de pacientes com fun\u00e7\u00e3o pulmonar reduzida, sem resposta a tratamento, em um grupo de crian\u00e7as e adolescentes com asma, e descrever as caracter\u00edsticas fenot\u00edpicas da amostra. M\u00c9TODOS: Foram selecionados pacientes ambulatoriais (5-17 anos) diagnosticados com asma persistente atrav\u00e9s de um question\u00e1rio padronizado. Esses pacientes foram submetidos a espirometria e teste cut\u00e2neo para aeroal\u00e9rgenos comuns. Definiu-se como fun\u00e7\u00e3o pulmonar persistentemente reduzida apresentar rela\u00e7\u00e3o VEF1\/CVF &lt; 0,80, mesmo ap\u00f3s ter recebido tratamento com broncodilatador e corticoide oral por 10 dias. O \u00edndice de intensidade de atopia foi utilizado para diferenciar pacientes pouco reatores daqueles multirreatores (ponto de corte: 4 al\u00e9rgenos). RESULTADOS: Foram inclu\u00eddos 96 pacientes, com m\u00e9dia de idade de 10,6 anos. Desses, 52 (54,1%) eram do sexo masculino, e 89 (92,7%) eram at\u00f3picos. Dos 96 pacientes, 8 (8,3%) apresentaram redu\u00e7\u00e3o da fun\u00e7\u00e3o pulmonar mesmo ap\u00f3s o tratamento. Desses pacientes, 8 (100%) eram at\u00f3picos, 7 (87,5%) apresentavam asma moderada ou grave, e 7 (87,5%) tinham hist\u00f3ria de hospitaliza\u00e7\u00e3o por bronquiolite aguda. CONCLUS\u00d5ES: Crian\u00e7as e adolescentes com asma moderada a grave podem apresentar fun\u00e7\u00e3o pulmonar reduzida e sem resposta a tratamento. Essa situa\u00e7\u00e3o cl\u00ednica \u00e9 pouco estudada em pa\u00edses em desenvolvimento, e seus fatores de risco e etiologia ser\u00e3o mais bem entendidos somente com estudos de coorte de nascimento.<\/jats:p>","DOI":"10.1590\/s1806-37132012000200003","type":"journal-article","created":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T14:16:56Z","timestamp":1363011416000},"page":"158-166","source":"Crossref","is-referenced-by-count":3,"title":["Fun\u00e7\u00e3o pulmonar persistentemente reduzida em crian\u00e7as e adolescentes com asma"],"prefix":"10.1590","volume":"38","author":[{"given":"Fernanda","family":"Luisi","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Araujo","family":"Pinto","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Marostica","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Herbert","family":"Jones","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Tetelbom","family":"Stein","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo M\u00e1rcio","family":"Pitrez","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul,  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